Evaluation of Photodynamic Therapy near Functional Brain Tissue in Patients with Recurrent Brain Tumors

Schmidt, Meic H.; Meyer, Glenn A.; Reichert, Kenneth W.; Cheng, Joseph; Krouwer, Hendrikus G. J.; Ozker, K; Whelan, Harry T.

doi:10.1023/b:neon.0000021804.50002.85

Cited by 66 publications

(42 citation statements)

References 29 publications

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“…The gender ratio varied with pathology, such that the more malignant the greater the male predilection. This phenomenon has previously been identified [14]. The mean performance score (Karnofsky score) was 80 AE 15 for the whole group, but 19 of 96 had a score of 70 and 8 had a score of 50.…”

Section: Gliomassupporting

confidence: 67%

Photodynamic therapy of brain tumors—A work in progress

2006

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Section: Gliomassupporting

confidence: 67%

Photodynamic therapy of brain tumors—A work in progress

2006

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“…25 We thereby used LEDs in this study. A mercury lamp irradiation system, which caused significant photodamage to tumor cells in research on ALA-PDT, 26 was also adopted to compare the PDT results with those after LED irradiation.…”

Section: Light Sourcementioning

confidence: 99%

Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid–gold nanoparticle conjugates in K562 cells via singlet oxygen generation

Liu²,

Mei³

et al. 2012

IJN

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Purpose: As a precursor of the potent photosensitizer protoporphyrin IX (PpIX), 5-aminolevulinic acid (5-ALA), was conjugated onto cationic gold nanoparticles (GNPs) to improve the efficacy of photodynamic therapy (PDT). Methods: Cationic GNPs reduced by branched polyethyleneimine and 5-ALA were conjugated onto the cationic GNPs by creating an electrostatic interaction at physiological pH. The efficacy of ALA-GNP conjugates in PDT was investigated under irradiation with a mercury lamp (central wavelength of 395 nm) and three types of light-emitting diode arrays (central wavelengths of 399, 502, and 621 nm, respectively). The impacts of GNPs on PDT were then analyzed by measuring the intracellular PpIX levels in K562 cells and the singlet oxygen yield of PpIX under irradiation. Results: The 2 mM ALA-GNP conjugates showed greater cytotoxicity against K562 cells than ALA alone. Light-emitting diode (505 nm) irradiation of the conjugates caused a level of K562 cell destruction similar to that with irradiation by a mercury lamp, although it had no adverse effects on drug-free control cells. These results may be attributed to the singlet oxygen yield of PpIX, which can be enhanced by GNPs. Conclusion: Under irradiation with a suitable light source, ALA-GNP conjugates can effectively destroy K562 cells. The technique offers a new strategy of PDT.

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“…17 In addition, during experiments of photodynamic therapy in a canine model, 670-nm light at an energy density of 100 J/cm 2 administered directly into the brain parenchyma did not cause the temperature of brain tissue to rise by more than 18C. 18 NIR light appears to exert therapeutic effects in multiple ways. Primarily, the light appears to alter the activity of cytochrome c oxidase in mitochondria 13,14,19,20 improving energy metabolism and production, thus increasing energy available for cell and tissue repair.…”

Section: Discussionmentioning

confidence: 99%

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

Hodgson

Pyszka

Henry

et al. 2011

Photomedicine and Laser Surgery

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Objective: The aim of this study was to investigate the effect of near-infrared (NIR) photobiomodulation on the proliferation and glutathione levels in murine Hertwig's epithelial root sheath (HERS) cells after poisoning with vinblastine. Background: Photobiomodulation has been shown to improve wound healing in a number of animal models. There have been no studies on the effect of photobiomodulation on cancer-related chemotherapy injury to the cells that initiate tooth root growth. Materials and Methods: Control groups consisted of murine HERS cells without vinblastine (VBÀ) and cells with vinblastine at 10, 20, and 30 ng/mL (VB10, VB20, and VB30). Experimental groups consisted of these same groups with light therapy (VB-L, VB10L, VB20L, and VB30L). The cells were exposed to vinblastine for 1 h.

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Evaluation of Photodynamic Therapy near Functional Brain Tissue in Patients with Recurrent Brain Tumors

Abstract: PDT with LED balloon adapters (also tunable dye laser) has acceptable toxicity in brain tumor patients. Future studies using more effective photosensitizers could improve local recurrence control.

Cited by 66 publications

References 29 publications

Photodynamic therapy of brain tumors—A work in progress

Photodynamic therapy of brain tumors—A work in progress

Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid–gold nanoparticle conjugates in K562 cells via singlet oxygen generation

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

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Evaluation of Photodynamic Therapy near Functional Brain Tissue in Patients with Recurrent Brain Tumors

Abstract: PDT with LED balloon adapters (also tunable dye laser) has acceptable toxicity in brain tumor patients. Future studies using more effective photosensitizers could improve local recurrence control.

Cited by 66 publications

References 29 publications

Photodynamic therapy of brain tumors—A work in progress

Photodynamic therapy of brain tumors—A work in progress

Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid&ndash;gold nanoparticle conjugates in K562 cells via singlet oxygen generation

Effect of Photobiomodulation on Vinblastine-Poisoned Murine HERS Cells

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Effects of light irradiation upon photodynamic therapy based on 5-aminolevulinic acid–gold nanoparticle conjugates in K562 cells via singlet oxygen generation