Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions

Zgadzaj, Anna; Skrzypczak, Agata; Welenc, Ilona; Ługowska, Agnieszka; Parzonko, Andrzej; Siedlecka, Ewa Maria; Sommer, Sylwester; Sikorska, Katarzyna; Nałęcz‐Jawecki, Grzegorz

doi:10.1016/j.jphotobiol.2015.01.015

Cited by 13 publications

(6 citation statements)

References 39 publications

(62 reference statements)

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“…S1). In addition, there are several reports that the photodegradation induces a change in the biological activity of dihydropyridine drugs [15][16] and other drugs [17][18][19][20]. In the case of amlodipine, the dehydro form that was generated in this experiment was generally less toxic than amlodipine against C. dubia, which is an aquatic organism [21].…”

Section: Identification Of An Amlodipine Photoproduct Structure In Su...mentioning

confidence: 77%

Photostabilities of Amlodipine OD Tablets in Different Dosage Forms

et al. 2022

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Amlodipine is a dihydropyridine drug that is used to lower high blood pressure. In this study, the photostabilities of orally disintegrating (OD) amlodipine tablets, both original and generic versions, and their powdered and suspended forms were evaluated. The concentration of the active pharmaceutical ingredient (API) was monitored by high-performance liquid chromatography (HPLC), revealing that residual amounts of API in powders and suspensions significantly decreased after ultraviolet light (UV) irradiation for 24 hr. Amlodipine OD tablets and their powders were packaged and stored at a house and a pharmacy for up to 90 days for the evaluation of their photostabilities in clinical use, and that amounts of API in the powdered form significantly decreased when they were stored in the house. ESI-LC/MS/MS analysis was performed to determine the chemical structure of photoproducts generated by photo-irradiated amlodipine OD tablets. It revealed that mainly a dehydrogenated form of amlodipine was generated concomitant with the photodegradation by UV and sunlight irradiation. This is the first study that evaluated the photostabilities of original amlodipine OD medicines, their generic OD versions and their altered forms.

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Section: Identification Of An Amlodipine Photoproduct Structure In Su...mentioning

confidence: 77%

Photostabilities of Amlodipine OD Tablets in Different Dosage Forms

et al. 2022

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“…According to a previous report, 1 (T 1 ) can readily form degradation products and the degradation reaction starts from a proposed demethylation reaction of the para - N -methyl-piperazine moiety based on steady-state photoproducts analysis, − so the peak at 525 nm is likely caused by the demethylation or subsequent photodegradation intermediates generated by 1 (T 1 ). The fs-TA spectra of 1 in ACN/H 2 O (at pH 7, v/v = 1:1) were also obtained (Figure S2) and show similar photophysical and photochemical behaviors as those obtained in neat ACN.…”

Section: Results and Discussionmentioning

confidence: 99%

Photophysical Properties Controlled by Substituents with Lone-Pair Electrons at the Ortho- or Para-Positions of Fluoroquinolone Antibiotics

et al. 2019

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The ortho- or para-substituents of NH2 or N-alkyl-containing lone-pair electrons were found to change the energy levels and transition configurations of the highest occupied molecular orbital for some fluoroquinolone-based antibiotics (FQs) and can significantly influence the electronic structure, intermolecular hydrogen bonding, internal conversion, and fluorescence and intersystem crossing efficiencies of FQs in acetonitrile or aqueous solution after photoexcitation. These findings provide new insights that can help in the molecular design strategies to regulate the photophysical properties of photosensitive medicines, photodynamic therapy reagents, and energy conversion materials that contain similar aromatic carbonyl structures.

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“…Tinosorb S and M: This is a diarylmethane and is commonly used in chemical sunscreens that can give protection against both long and short wavelength UV-A and UV-B radiation. It also provides stability to other UV filters, and up to 10% is allowed in sunscreen formulations, making it suitable for sunscreens [ 35 , 48 ].…”

Section: Damaging Effects Of Uvr On Skinmentioning

confidence: 99%

Exploring Mycosporine-Like Amino Acids (MAAs) as Safe and Natural Protective Agents against UV-Induced Skin Damage

et al. 2021

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Prolonged exposure to harmful ultraviolet radiation (UVR) can induce many chronic or acute skin disorders in humans. To protect themselves, many people have started to apply cosmetic products containing UV-screening chemicals alone or together with physical sunblocks, mainly based on titanium–dioxide (TiO2) or zinc-oxide (ZnO2). However, it has now been shown that the use of chemical and physical sunblocks is not safe for long-term application, so searches for the novel, natural UV-screening compounds derived from plants or bacteria are gaining attention. Certain photosynthetic organisms such as algae and cyanobacteria have evolved to cope with exposure to UVR by producing mycosporine-like amino acids (MAAs). These are promising substitutes for chemical sunscreens containing commercially available sunblock filters. The use of biopolymers such as chitosan for joining MAAs together or with MAA-Np (nanoparticles) conjugates will provide stability to MAAs similar to the mixing of chemical and physical sunscreens. This review critically describes UV-induced skin damage, problems associated with the use of chemical and physical sunscreens, cyanobacteria as a source of MAAs, the abundance of MAAs and their biotechnological applications. We also narrate the effectiveness and application of MAAs and MAA conjugates on skin cell lines.

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Evaluation of photodegradation, phototoxicity and photogenotoxicity of ofloxacin in ointments with sunscreens and in solutions

Cited by 13 publications

References 39 publications

Photostabilities of Amlodipine OD Tablets in Different Dosage Forms

Photostabilities of Amlodipine OD Tablets in Different Dosage Forms

Photophysical Properties Controlled by Substituents with Lone-Pair Electrons at the Ortho- or Para-Positions of Fluoroquinolone Antibiotics

Exploring Mycosporine-Like Amino Acids (MAAs) as Safe and Natural Protective Agents against UV-Induced Skin Damage

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