Evaluation of phenolic profile, antioxidant and anticholinesterase effects of Fuscoporia torulosa

Abstract

In this study, we investigated antioxidant and anticholinesterase activities of the hexane, chloroform, acetone, methanol and water extracts of F. torulosa mushroom with total phenolic contents. Also, HPLC-DAD was used to identify phenolic profile of F. torulosa. The acetone and methanol extracts of F. torulosa with the highest total phenolic contents showed the highest antioxidant activity in all assays except metal chelating assay. Furthermore, antioxidant activities of the acetone and methanol extract were found to be higher than αtocopherol and BHA used as standards in DPPH • , ABTS • and CUPRAC assays. When F. torulosa hexane extract (41.34±1.50 %) showed moderate AChE inhibitory activity, the acetone (40.78±0.30 %) and methanol (45.39±0.65 %) extracts of F. torulosa indicated moderate BChE inhibitory activity. Major phenolic compounds were identified as trans-2-hydroxy cinnamic acid (10.05 µg/g), gallic acid (5.01 µg/g) and p-coumaric acid (3.04 µg/g). These results suggest that F. torulosa mushroom could be used as a valuable natural antioxidant source for pharmaceutical industry. ARTICLE HISTORY

Triterpenes and Phenolic Compounds From the Fungus <em>Fuscoporia torulosa</em>: Isolation, Structure Determination and Biological Activity

“…These differences were in accordance with the proposition that the double bond between C-6 and C-7 was in cis configuration in the minor component. 13 C, COSY, HSQC and HMBC data confirmed the proposed structures and enabled the complete 1 H and 13 C NMR assignments of both components. Homonuclear ROESY data were also in accordance with these structural conclusions.…”

“…The fungal metabolites were examined for their potential cytotoxic, antioxidant, cholinesterase, and tyrosinase inhibitory activities (Deveci et al). Besides these mycochemical studies several articles reported on the antimicrobial, antioxidant, cytotoxic and xanthine oxidase inhibitory, and anti-acne activities and the phenolic profile of F. torulosa samples prepared with solvents of different polarities [2,[12][13][14].…”

Triterpenes and Phenolic Compounds from the Fungus Fuscoporia torulosa: Isolation, Structure Determination and Biological Activity

“…The fungal metabolites were examined for their potential cytotoxic, antioxidant, cholinesterase, and tyrosinase inhibitory activities [ 12 ]. Besides these mycochemical studies, several articles reported the antimicrobial, antioxidant, cytotoxic, and xanthine oxidase inhibitory capacities, and the antiacne activities and the phenolic profile of F. torulosa samples prepared with solvents of different polarities [ 2 , 13 , 14 , 15 ].…”