Evaluation of phenolic assays for the detection of nitrite

Metabolic mimics: Thiol responsive drug release

“…All other solutions were prepared using BrittonRobinson buffer (acetic, boric and phosphoric acids-each at a concentration of 0.04 M) containing 0.1 M KCl. Nitrite was subsequently derivatised using phloroglucinol (1,3,5-trihydroxybenzene) to yield the 2-nitroso derivative [11].…”

Advances in the Voltammetric Analysis of Small Biologically Relevant Compounds

“…Judicious choice of the base material itself however can be used to enhance the electrode performance but more importantly ensures that a quantifiable signal can be obtained. Thus, the large hydrogen overpotentials exhibited by mercury-, carbon-, and boron-doped diamond opens up an extensive cathodic window within which reduction processes can be exploited (typically those involving nitroso (75,76) and nitro (77) groups). This contrasts the use of conventional metallic electrodes as the onset of hydrogen ion reduction, particularly in acidic media, may obscure the analytical signal.…”

“…This is particularly true when dealing with spatially distant redox labels where inductive and field effects attributed to the modification may be less significant. The most common recourse has been to introduce an entirely new redox label onto the target analyte with the aim of placing the analytical signal within a potential region where there are few natural interferences (4,20,53,60,68,76). In addition, the electrochemical conversion of the appended redox group may confer other advantages such as improved sensitivity.…”

“…In addition, the electrochemical conversion of the appended redox group may confer other advantages such as improved sensitivity. Both aspects are typified by the use of nitrite-induced nitrosation of 1,3,5-trihydroxybenzene as a means of detecting the former (76). Rather than deriving the analytical signal from the one electron oxidation of the anion, the four-electron reduction of the nitroso group provides an inherently more sensitive path that occurs at a potential where ascorbate inference is negligible.…”

Spectrophotometric Determination of Nitrite Based on Its Reaction with p-Nitroaniline in the Presence of Diphenylamine in Micellar Media

“…1 Nitrite is also a versatile chemical agent, which has found numerous applications ranging from dye manufacture to food preservation. 2 Moreover the determination of nitrite in natural waters is important, being harmful to human health.…”