Evaluation of Pharmacokinetics of Boronophenylalanine and Its Uptakes in Gastric Cancer

Tang, Futian; Wei, Yujie; Zhang, Shining; Wang, Jianrong; Gu, Wenjiao; Tang, Fenxia; Peng, Xiaohuan; Wei, Yucai; Liu, Jiangyan; Chen, Weiqiang; Zhang, Shixu; Gu, Leyi; Li, Yumin

doi:10.3389/fonc.2022.925671

Cited by 6 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Boron and its metabolites are excreted primarily by the urinary system, which explains the high concentrations of boron in the kidneys (Tang et al, 2022). Horn et al (1997) revealed that a single infusion of sodium borocaptate can induce some alterations in the function of a normal kidney, resulting in a reduction of the filtration fraction.…”

Section: Discussionmentioning

confidence: 99%

Lithium salts cytotoxicity and accumulation in melanoma cells in vitro

Taskaeva,

Kasatova,

Razumov

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

Boron neutron capture therapy is a perspective selective technology for the destruction of cancer cells, while the use of lithium instead of boron may represent a new and promising vector for the development of neutron capture therapy (NCT). The aim of the study was a comparative assessment of the cytotoxicity of various lithium salts, as well as an analysis of the accumulation of lithium in tumor cells in vitro to determine the possibility of using lithium in NCT. The cytotoxicity of lithium salts was determined using MTT‐test and colony forming assay on human fibroblasts BJ‐5ta, human skin melanoma SK‐Mel‐28, and mouse skin melanoma B16 cell lines. An assessment of lithium concentration in cells was performed using inductively coupled plasma atomic emission spectrometry. Our results showed that three different lithium salts at a concentration of 40 μg/ml are not toxic for both tumor and normal cells. The highest uptake values were obtained on murine melanoma B16 cells when exposed to lithium carbonate (0.8 μg/106 cells); however, human melanoma SK‐Mel‐28 cells effectively accumulated both lithium carbonate and lithium citrate (about 0.46 μg/106 cells for two salts). Thus, our results demonstrate a range of non‐toxic doses of lithium salts and a high uptake of lithium by tumor cells, which indicates the possibility to use the lithium in NCT.

show abstract

Section: Discussionmentioning

confidence: 99%

Lithium salts cytotoxicity and accumulation in melanoma cells in vitro

Taskaeva,

Kasatova,

Razumov

et al. 2023

J of Applied Toxicology

View full text Add to dashboard Cite

show abstract

“…The distribution of boron in different tissues (heart, liver, lung, stomach, and small intestine) of rats revealed a similar pattern in blood except for that in the brain, kidney, and bladder; also noted is that BPA is preferentially distributed in tumor tissue rather than in blood or normal tissues. Although the mechanism for this distribution is unclear …”

Section: Pharmacokinetics Of Some Boron-containing Compoundsmentioning

confidence: 99%

“…Although the mechanism for this distribution is unclear. 688 Other facts in BCC-distribution are not elucidated; as an example, not all boronic acids with a good volume of distribution can reach the whole organism. Thus, bortezomib, an dipeptide boronic acid, has wide distribution but limited access to the central nervous system.…”

Section: Boric and Boronic Acidsmentioning

confidence: 99%

The Rise of Boron-Containing Compounds: Advancements in Synthesis, Medicinal Chemistry, and Emerging Pharmacology

Grams,

Santos,

Scorei

et al. 2024

Chem. Rev.

View full text Add to dashboard Cite

Boron-containing compounds (BCC) have emerged as important pharmacophores. To date, five BCC drugs (including boronic acids and boroles) have been approved by the FDA for the treatment of cancer, infections, and atopic dermatitis, while some natural BCC are included in dietary supplements. Boron's Lewis acidity facilitates a mechanism of action via formation of reversible covalent bonds within the active site of target proteins. Boron has also been employed in the development of fluorophores, such as BODIPY for imaging, and in carboranes that are potential neutron capture therapy agents as well as novel agents in diagnostics and therapy. The utility of natural and synthetic BCC has become multifaceted, and the breadth of their applications continues to expand. This review covers the many uses and targets of boron in medicinal chemistry.

show abstract