Evaluation of Phage and Antibiotic Combinations forStaphylococcus aureusBiofilm Eradication: Insights from the Wax Worm Model
L Archana,
Prasanth Manohar,
Bulent Bozdogan
et al.
Abstract:BackgroundGalleria mellonella, an advantageous model organism, to investigate the therapeutic potential of bacteriophages. Employing theGalleria mellonella(waxworm) model, this study involved infecting the larvae with pathogenicStaphylococcus aureus, followed by combination treatment with staph phages; vB_Sau_Saa90 and vB_Sau_Saa165 at the concentrations of 107and 109PFU/mL and oxacillin, at 100 mg/kg. The treatment modalities were executed in three distinct orders: pre-phage treatment, simultaneous treatment,… Show more
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