Evaluation of peripheral serotonin content and α<sub>2</sub>-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements

Aleksovski, Boris; Novotni, Antoni; Vujovic, V.; Rendevski, Vladimir; Manusheva, Nensi; Neceva, V.; Filipce, Ana; Risteski, Aleksandar; Aleksovski, Vasko; Gjorgoski, Icko

doi:10.1080/13651501.2017.1411516

Cited by 7 publications

(6 citation statements)

References 40 publications

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“…The analysis of the 5-HT content in platelets and serum showed lower 5-HT contents in patients compared with healthy participants. These findings are in accordance with several previous studies (Aleksovski et al, 2018;Maurer-Spurej et al, 2004) and suggest a dysregulation of the serotonergic system in the peripheral blood of depressed patients.…”

Section: Interaction Of Serotonin and The Immune Systemsupporting

confidence: 94%

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

Obermanns

Krawczyk

Juckel

et al. 2021

Eur J of Neuroscience

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Section: Interaction Of Serotonin and The Immune Systemsupporting

confidence: 94%

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

Obermanns

Krawczyk

Juckel

et al. 2021

Eur J of Neuroscience

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“…In recent studies, it has been suggested that there is no difference between platelet 5-HT levels between patients with depressive symptoms and healthy individuals (33,34). Although the findings of our study show that 5-HT levels are affected by familial stressors, they do not provide sufficient evidence.…”

Section: Discussioncontrasting

confidence: 99%

The effect of some family characteristics on the relationship between mental symptoms and levels of serum serotonin and salivatory cortisol

Maden

Uzun

2023

Journal of Health Sciences and Medicine

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Introduction: Psychological symptoms (PSs) are also seen in healthy individuals. The aim of this study is to examine some familial characteristics in the relationship between PSs and serum serotonin (5-HT) and salivary cortisol (sCTS) levels in healthy individuals. Materials and Method: A sociodemographic data form and a psychiatric symptom screening questionnaire (SCL-90-R) were given to 320 healthy individuals (156 males, 164 females) aged between 18-65 years and without any mental illness. Blood and saliva samples were duly taken and evaluated by ELISA method. The research protocol was approved by the Ankara Keçiören Training and Research Hospital Clinic Research Ethics Committee (study number KÖTRH-CREC_11.07.2012/103). Informed consent was obtained from the participants before participating in the study. Statistical analyzes were performed with the SPSS 15.0 program. Descriptive statistical data (number, percentage, mean, standard deviation, minimum and maximum), independent sample t test, One-way ANOVA test, Kruskal Wallis H test, Mann-Whitney U test, Pearson Correlation analysis were used in the analyzes. For statistical significance, p˂.05 was accepted as significant. Results: The highest PS levels of the participants were obsessive-compulsive symptoms (.92±.80), interpersonal sensitivity (.75±.55) and depressive symptoms (.72±.53), respectively. The general symptom index (GSI) was .61±.46. Psychotic (χ2(2)=7.021, p=.03) and phobic symptoms (χ2(2)=7.130, p=.03) in those living in a nuclear family, depression levels in those whose parents lived together (t=-2.114, p=.04) was lower. Somatization, anxiety, obsession, depression, interpersonal sensitivity, psychoticism, paranoid, thought, hostility and additional symptom levels were highest in illiterate parents. Phobic symptom levels were highest in those whose fathers were illiterate. In patients with a family history of psychiatric illness, somatization (t=2.108, p=.04), anxiety (t=2.103, p=.02), obsession (t=2.146, p=.03), depression (t=2.548, p=.01), anger-hostility (t=3.096, p=

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“…Regarding the content of serotonin in serum and platelets, we detected lower serotonin contents in patients compared to healthy participants. These findings are in line with several previous studies, whereas others revealed no differences in platelet serotonin content between patients suffering from depression and healthy participants [ 9 , 43 , 44 , 45 ]. Concerning the decreased peripheral serotonin concentration in patients compared to healthy controls, it should be considered that the influence of SSRI/SNRIs is reflected in these results.…”

Section: Discussionsupporting

confidence: 93%

“…More investigations are adjuvant to clarify the implication of combining medications in the treatment of depression. Interestingly, Aleksovski and colleagues suggested that the peripheral abnormalities in serotonin content are caused by an altered function of the serotonin transporter [ 43 , 49 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Serotonergic Activity and the Serotonin Content in Serum and Platelet, and the Possible Role of the Serotonin Transporter in Patients with Depression

Obermanns

Flasbeck

Steinmann

et al. 2022

Behavioral Sciences

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According to the monoamine hypothesis, the development of depression is associated with dysfunctions of the serotonergic system. Alterations in the serotonin transporter gene (5-HTTLPR), the serotonergic activity in the brain, and the content of serotonin (5-HT) have been related to depression and were examined separately by previous studies. This study investigates these parameters in 89 depressed patients and 89 healthy participants. We investigated the serotonergic activity measured by the loudness dependence of auditory evoked potentials (LDAEP). In addition to the examination of the serotonin content (serum and platelet), enzyme-linked immunosorbent assays (ELISA) were used and 5-HTTLPR genotypes were analyzed. We observed a lower serotonin content in patients compared to healthy participants. Further, we noticed a correlation between anxiety and depression-associated symptoms with serotonergic activity. Patients treated with SSRI/SNRI showed decreased contents of serum serotonin compared to patients without any psychotropic medication or other psychotropic medications. Since the serotonergic activity, peripheral serotonin content, and 5-HTTLPR were unrelated, the results suggest independent alterations of central and peripheral serotonergic systems in depression. In line with this finding, serotonergic activity was related to anxiety and depression symptoms. Furthermore, the applied medication seems to influence serum serotonin content in patients with depression.

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Evaluation of peripheral serotonin content and α₂-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements

Abstract: The evaluated peripheral markers reflect only state (but not trait) abnormalities in patients with current severe episode of RDD. The observed peripheral α-AR and serotonin abnormalities are mutually not related and they are probably triggered by different mechanisms.

Cited by 7 publications

References 40 publications

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

The effect of some family characteristics on the relationship between mental symptoms and levels of serum serotonin and salivatory cortisol

Investigation of the Serotonergic Activity and the Serotonin Content in Serum and Platelet, and the Possible Role of the Serotonin Transporter in Patients with Depression

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Evaluation of peripheral serotonin content and α2-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements

Abstract: The evaluated peripheral markers reflect only state (but not trait) abnormalities in patients with current severe episode of RDD. The observed peripheral α-AR and serotonin abnormalities are mutually not related and they are probably triggered by different mechanisms.

Cited by 7 publications

References 40 publications

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression

The effect of some family characteristics on the relationship between mental symptoms and levels of serum serotonin and salivatory cortisol

Investigation of the Serotonergic Activity and the Serotonin Content in Serum and Platelet, and the Possible Role of the Serotonin Transporter in Patients with Depression

Contact Info

Product

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About

Evaluation of peripheral serotonin content and α₂-adrenergic receptor function as potential markers for life-long recurrent depressive disorder by using methodological improvements