Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma

Hirooka, Kazuyuki; Tenkumo, Kaori; Fujiwara, Atsushi; Baba, Tetsuya; Sato, Shino; Shiraga, Fumio

doi:10.1186/1471-2415-12-29

Cited by 104 publications

(95 citation statements)

References 27 publications

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“…The choroid exhibited a similar pattern in controls and patients with POAG; it was GON [7,8] , results of the involvement of the peripapillary choroid and GON are mixed. Some authors reported a reduction in the mean or regional peripapillary choroidal thickness (PPCT) in primary open-angle glaucoma (POAG), especially in association with sclerotic optic disk damage [9] and normal tension glaucoma [10,11] . Others found no differences among glaucoma, healthy, and glaucoma-suspect eyes with regard to peripapillary choroidal structures [12,13] .…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

et al. 2017

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Aims: To evaluate and compare peripapillary choroidal thickness (PPCT) in a wide area around the optic disk and various choroidal established zones in healthy controls and primary open-angle glaucoma (POAG) patients using a new swept-source (SS) optical coherence tomography (OCT) device. Methods: A total of 246 eyes were finally included in this observational, prospective, cross-sectional study: 111 healthy controls and 135 POAG patients. The healthy subjects were divided into 2 populations: the teaching population (25 used to establish choroidal zones) and the validating population (86 used for comparing choroidal thickness with POAG patients). A 26 × 26 cube grid centered on the optic disk was generated using an SS-OCT to automatically measure choroidal thickness. Four choroidal zones were established and used to compare PPCT between healthy controls and POAG patients. Results: PPCT was significantly thinner in zones 3 and 4 of the POAG group. The choroid exhibited a similar pattern in controls and patients with POAG; it was thickest in the superior region, followed in order by the temporal, nasal, and inferior regions. Conclusions: Peripapillary choroidal tissue shows a concentric pattern in both groups, and glaucoma patients present with peripapillary choroidal thinning compared with healthy subjects, especially in areas further away from the optic disk.

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Section: Introductionmentioning

confidence: 99%

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

et al. 2017

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“…Für die pAD speziell wurde eine Assoziation mit dem diastolischen Blutdruck [7], der Achsenlänge, der zentralen Hornhautdicke [7], dem Lebensalter [12,13] und dem Papillenabstand [14] nachgewiesen. Die pAD ist im inferioren Bereich [14] (infero-nasal, inferior und infero-temporal [13,15]) signifikant dünner als in den anderen peripapillären Lokalisationen.…”

Section: Hintergrundunclassified

“…Bisher gibt es einige Publikationen, die eine Assoziation von pAD und Glaukom mittels SD-OCT analysierten, allerdings mit widersprüchlichen Resultaten [12,13,15,[18][19][20]. In der vorgestellten Pilotstudie wurde die pAD in unterschiedlichen Abständen zur Papille bei kaukasischen POWG-Probanden mit Augengesunden verglichen.…”

Section: Hintergrundunclassified

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Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom

Zimmermann¹,

Plöger

Kramm

et al. 2015

Spektrum Augenheilkd.

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ZusammenfassungHintergrund Vaskuläre Theorien zur Pathogenese des primären Offenwinkelglaukoms (POWG) und zur papillären Blutversorgung lassen Veränderungen der peripapillären Aderhaut bei POWG vermuten. Die prospektive Studie vergleicht die peripapilläre Aderhautdicke (pAD) bei POWG mit Augengesunden.Material und Methoden Die pAD wurde mittels SD-OCT in 300, 600 und 900 μm Abstand zur Papille für 12 Halbmeridiane bestimmt. An der Studie nahmen 15 Probanden mit POWG (kaukasisch, Alter 65,7 ± 10,6 Jahre) und 9 augengesunde Probanden (kaukasisch, Alter 59,4 ± 14,7 Jahre) teil.Resultate In Augen mit POWG war die pAD um durchschnittlich 15,2 % (89,0 ± 34,4 versus 105,4 ± 26,8 μm, p < 0,001) reduziert. Der Unterschied zum Normalauge wird mit zunehmendem Abstand zur Papille geringer: 300 µm: 20,5 % (77,9 ± 33,7 versus 98,0 ± 25,0 μm, p = 0,002), 600 µm: 12,9 % (93,2 ± 32,6 versus 107,0 ± 27,3 μm, p = 0,002), 900 µm: 12,7 % (97,2 ± 32,4 versus 111,3 ± 26,4 μm, p = 0,002). In Bezug auf die Halbmeridiane waren in den verschiedenen Papillenabständen im nasalen Bereich signifikante Unterschiede der pAD nachweisbar. Nach Bonferroni-Holm-Korrektur ist keine Signifikanz der pAD-Unterschiede mehr vorhanden (p > 0,05 für alle Halbmeridiane).Schlussfolgerung Bei Patienten mit POWG ist die pAD signifikant reduziert. Das Ergebnis unterstützt die vaskuläre Theorie für die Pathogene des POWG. In zukünftigen Studien gilt es herauszuarbeiten, ob die Reduktion der Aderhautdicke bei verschiedenen Glaukomformen gleichermaßen auftritt und inwieweit die Aderhautdicke von systemischen Erkrankungen beeinflusst wird.Schlüsselwörter Peripapilläre Aderhautdicke · Spectral-Domain Optische Kohärenz Tomographie · Primär chronisches Offenwinkelglaukom · Glaukompathogenese · Perfusionsstörung Correlation of peripapillary choroidal thickness and primary open angle glaucoma SummaryBackground Vascular theories of pathogenesis of primary open angle glaucoma (POAG) and of papillary blood supply suggest changes of the peripapillary choroid by POAG. This prospective study compares the peripapillary choroidal thickness (PCT) in POAG with normal eyes.Material and methods PCT was measured by SD-OCT in 300, 600 and 900 μm distance from the papilla, for 12/2 meridians determined. The study involved 15 subjects with POAG (caucasian, age 65.7 ± 10.6 years) and 9 subjects without POAG part (caucasian, age 59.4 ± 14.7 years).Results POAG-subjects showed a reduction by an average PCT of 15.2 % (89.0 ± 34.4 versus 105.4 ± 26.8 microns, p < 0.001). The difference to normal subjects decreases with increasing distance from the papilla: 300 μm: 20.5 % (77.9 ± 33.7 versus 98.0 ± 25.0 μm, p = 0.002), 600 μm: 12.9 % (93.2 ± 32.6 versus 107.0 ± 27,3 μm, p = 0.002), 900 μm: 12.7 % (97.2 ± 32.4 versus 111.3 ± 26.4 μm, p = 0.002). Regarding the half-meridians, significant diforiginalarbeit Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom 125 1 3 ferences were detected in the nasal area. There is no significant PCT-difference jusing Bonferroni-Holm-cor...

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“…Zhang et al did not identify a relationship between peripapillary and macular choroidal thickness and the markers of severity of glaucoma (MD and RNFL thickness) (66) . Using the enhanced depth imaging (EDI) OCT, Hirooka et al obser ved a reduced choroidal thickness in the inferonasal, inferior, and inferotemporal regions in the NTG patients compared with that in normal subjects (67) . Park et al compared the macular and peripapillary choroidal thickness of normal subjects and high-pressure POAG and NTG patients and found no significant differences in macular thickness among the groups.…”

Section: Choroidal Thicknessmentioning

confidence: 99%

Normal-tension glaucoma: an update

Esporcatte¹,

Tavares²

2016

Arquivos Brasileiros De Oftalmologia

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However, several structural and functional differences support the fact that different mechanisms may have a stronger role in the pathogenesis of NTG versus high-pressure POAG. Also, a recent study reported genetic variants associated with different tendencies towards POAG with lower or higher IOP (6) . Furthermore, clinical impression and anecdotal evidence suggest that NTG with mean IOP in the high teens (>15 mmHg), in which circadian fluctuation and CCT could lead to a possible misdiagnosis of an IOP ≤21 mmHg, would differ from NTG with mean IOP in the low teens (≤15 mmHg), with different ABSTRACT Descritores: Glaucoma de ângulo aberto; Pressão in traocular; Doenças do nervo óptico; Anti-hipertensivos/uso terapêuticopathogenesis and progression patterns, harder to achieve target IOP, and higher incidence of disc hemorrhages. Nonetheless, a recent report does not support this assumption and underscores low-teens NTG as an important entity (7) . The proportion of NTG varies depending on different population studies. In Asian epidemiological protocols, NTG constituted the majority of open-angle glaucomas (52%-92%), depending on the country and study methodology (8) . Normal IOP was measured in 57.1% cases of POAG in a South African study (9) . In white populations, the proportion of NTG was lower than that observed in Asian and African populations. In studies conducted in the United States, Netherlands, and Italy, NTG presented proportions of 31. 7%, 38.9%, and 30%, respectively (10-12) . The etiology of NTG is most likely multifactorial and still not well defined. Moreover, several alternative treatments based on this different pathogenesis have been discussed. The objective of this study was to review the mechanisms involved in the onset and progression of NTG and the efficacy of established and alternative therapies for NTG treatment. PathogenesisThe pathogenesis of NTG is unclear, and perhaps the development of the disease is a consequence of a complex interaction of several systemic and ocular factors. Different studies have shown that the cardiovascular system and intracranial pressure may be involved in the main pathways of optic nerve damage. Nevertheless, the complex relationship between these mechanisms and glaucoma pro gression continues to be debated.

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Evaluation of peripapillary choroidal thickness in patients with normal-tension glaucoma

Cited by 104 publications

References 27 publications

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

Peripapillary Choroidal Thickness Analysis Using Swept-Source Optical Coherence Tomography in Glaucoma Patients: A Broader Approach

Korrelation von peripapillärer Aderhautdicke und primärem Offenwinkelglaukom

Normal-tension glaucoma: an update

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