Abstract:In this study, we showed that PTX-3 levels, in both FMF attack and attack-free periods, were significantly higher than in the control group. Finally, PTX-3 may be a promising biomarker for FMF diagnosis and may predict FMF attacks (Tab. 2, Fig. 2, Ref. 18).
“…Higher ESR, CRP, fibrinogen, white blood cell count, and serum amyloid A (SAA) are expected results in active FMF disease compared to the attack-free period. 8 , 9 However, in a systematic review investigating APR used for FMF diagnosis, Erer et al reported that there was no effective APR to diagnose FMF disease. 9 …”
Objective:
While several inflammatory markers are known to increase in familial Mediterranean fever (FMF) disease cases, the need remains for diagnostic tests specific for FMF that monitor inflammatory activity. We aimed to investigate resistin and calprotectin levels during both attack and attack-free periods of FMF disease and evaluate their use as novel biomarkers of inflammation in patients with FMF.
Materials and Methods:
This cross-sectional study included 68 male patients diagnosed with FMF and 20 healthy individuals as controls. Blood samples were obtained from the patients in attack-free periods (at least 15 days after the last attack) and attack periods (in the first 24 hours). Serum resistin and plasma calprotectin levels was measured by ELISA method.
Results:
Resistin and calprotectin levels were significantly higher in patients during both attack (p =0.001, p <0.001) and attack-free periods (p =0.017, p =0.01) compared to the control group. Logistic regression analysis indicated that resistin levels were predictive for the diagnosis of FMF disease (OR: 1.21; 95% CI: 1.04–1.42; p =0.016). Resistin and calprotectin levels significantly correlated with C-reactive protein, erythrocyte sedimentation rate, fibrinogen, and white blood cells (0.301≤ r ≤ 0.505, p <0.05).
Conclusion:
Resistin and calprotectin levels were significantly higher in patients than controls, and resistin was predictive for monitoring inflammatory activity in patients with FMF.
“…Higher ESR, CRP, fibrinogen, white blood cell count, and serum amyloid A (SAA) are expected results in active FMF disease compared to the attack-free period. 8 , 9 However, in a systematic review investigating APR used for FMF diagnosis, Erer et al reported that there was no effective APR to diagnose FMF disease. 9 …”
Objective:
While several inflammatory markers are known to increase in familial Mediterranean fever (FMF) disease cases, the need remains for diagnostic tests specific for FMF that monitor inflammatory activity. We aimed to investigate resistin and calprotectin levels during both attack and attack-free periods of FMF disease and evaluate their use as novel biomarkers of inflammation in patients with FMF.
Materials and Methods:
This cross-sectional study included 68 male patients diagnosed with FMF and 20 healthy individuals as controls. Blood samples were obtained from the patients in attack-free periods (at least 15 days after the last attack) and attack periods (in the first 24 hours). Serum resistin and plasma calprotectin levels was measured by ELISA method.
Results:
Resistin and calprotectin levels were significantly higher in patients during both attack (p =0.001, p <0.001) and attack-free periods (p =0.017, p =0.01) compared to the control group. Logistic regression analysis indicated that resistin levels were predictive for the diagnosis of FMF disease (OR: 1.21; 95% CI: 1.04–1.42; p =0.016). Resistin and calprotectin levels significantly correlated with C-reactive protein, erythrocyte sedimentation rate, fibrinogen, and white blood cells (0.301≤ r ≤ 0.505, p <0.05).
Conclusion:
Resistin and calprotectin levels were significantly higher in patients than controls, and resistin was predictive for monitoring inflammatory activity in patients with FMF.
“…Higher ESR, CRP, fibrinogen, white blood cell count, and serum amyloid A (SAA) are expected results in FMF disease compared to the attack-free period [17,18]. However, in a systematic review investigating acute phase reactants used for FMF diagnosis, Erer et al reported that there was no effective acute phase reactant to diagnose FMF disease [18].…”
Section: Discussionmentioning
confidence: 99%
“…There are other new candidate biomarkers for FMF in the literature [17,[24][25][26][27][28][29][30][31]. Pentraxin-3, omentin, fetuin, calprotectin, serum amyloid A, CD144 + , and CD146 + as circulating endothelial microparticles, endocan, chitotriosidase, serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1, S10012A and resolvin D1 has been investigated and had promising results.…”
Background/aim
Familial Mediterranean fever
(
FMF) is a disease that is mainly diagnosed with clinical features. Several well-known inflammatory markers increase in FMF. However, there is still a need for diagnostic tests for specifying FMF and monitoring inflammatory activity. CXCL16 is a chemokine produced by inflammatory cells that demonstrate efficacy in the acute phase response. In this study, we aimed to investigate the relationship between CXCL16 levels and FMF disease and to evaluate CXCL16 levels as a novel biomarker for FMF.
Materials and methods
Fifty-three male patients diagnosed with FMF and sixty healthy individuals were included in this cross-sectional study. Blood samples were taken in the first 24 h of the attack periods. Serum soluble CXCL16 was evaluated by enzyme-linked immunosorbent assay (ELISA) method.
Results
CXCL16 (P < 0.001), erythrocyte sedimentation rate (P < 0.001), C-reactive protein (P < 0.001), and fibrinogen (P = 0.005) were significantly higher in FMF group than in control group. Receiver operating characteristic (ROC) curve analysis revealed a cut off value of CXCL16 as 2.68 ng/ml with 83% sensitivity and 68% specificity (P < 0.001). Logistic regression analysis indicated that high CXCL16 and erythrocyte sedimentation rate levels were predictive parameters for FMF disease (OR 8.31; 95% CI 2.59-26.62; p <0.001) (OR 1.27; 95% CI 1.12-1.44; P < 0.001). There was no correlation between CXCL16 levels and attack frequency and disease duration (P = 0.395, P = 0.956).
Conclusion
To the best of our knowledge, this is the first study evaluating serum soluble CXCL16 levels as a biomarker for FMF. CXCL16 levels were significantly higher and were predictive for monitoring inflammatory activity in patients with FMF. CXCL16 may be a promising biomarker for FMF diagnosis.
“…In the present study, PTX3 levels were low in FMF patients with sufficient vitamin D status. Gok et al [4] determined that the PTX-3 level was higher in young adults in the attackfree period compared to the control, and PTX-3 had a sensitivity of 90% at a threshold value of 0.696 ng/mL. In the present study, we divided the patients into two groups according to cut-off value (0.640) for PTX-3, we found that vitamin D levels were significantly lower in the patient group with subclinical inflammation.…”
Section: It Has Been Suggested That Low Vitamin D Levels In Patients With Fmf May Induce Subclinical Inflammation Since Vitamin D Has An mentioning
confidence: 99%
“…PTX-3 levels were found to be higher in patients with FMF during attack and attack-free periods compared to control despite the use of colchicine. Some researchers have suggested that PTX-3 can be an indicator of subclinical inflammation [4][5][6]. Subclinical inflammation increases the risk of developing complications such as anemia, heart disease, and amyloidosis in patients with FMF.…”
Background/aim: Vitamin D levels have been investigated in children with familial Mediterranean fever (FMF), but the relationship between vitamin D status and inflammation/oxidative stress indicators could not be clearly demonstrated. This study aimed to investigate the relationship between subclinical inflammation/oxidative stress and vitamin D status in children with FMF during an attack-free period.
Materials and methods:In the cross-sectional study, ninety children with FMF in the attack-free period and 30 healthy children were included in the study. Patients were grouped according to their vitamin D status (<20, 20-29, and 30-100 ng/mL). The groups were compared in terms of pentraxin 3 (PTX-3), total oxidant status (TOS), and total antioxidant status (TAS). Multivariable linear regression analysis was performed to identify factors associated with vitamin D status.Results: PTX-3 levels were significantly higher in patients with vitamin D insufficiency (20-29 ng/mL) than in the group with vitamin D sufficient (30-100 ng/mL). Patients with vitamin D deficiency (< 20 ng/mL) had higher TOS. A strong negative correlation was observed between vitamin D levels and TOS (p = 0.003). Subclinical inflammation (PTX-3 ≥0.640) and high TOS levels were negatively associated with vitamin D levels.
Conclusion:Subclinical inflammation and oxidative stress were negatively associated with vitamin D levels in patients with FMF during an attack-free period. Sufficient vitamin D levels are important in fighting subclinical inflammation and oxidative stress in children with FMF.
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