Evaluation of Peak Nasal Inspiratory Flow as an Objective Method of Measuring Nasal Airflow

Teixeira, Rodrigo Ubiratan Franco; Zappelini, Carlos Eduardo Monteiro; Costa, Everardo Andrade da; Alves, Fabio Eduardo Maiello Monteiro

doi:10.1177/0194599811415823a404

Cited by 23 publications

(41 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is well documented that nasal congestion is correlated with restricted lower nasal airflow function in adults with seasonal rhinitis . Key studies have demonstrated that PIFR measurements reflect the severity of nasal signs of rhinitis in a general population sample of young adults . The strong association between PFIR and rhinitis signs in this study provides objective and complementary evidence of the decrease in response and symptom scores of the patient, during nasal challenge testing.…”

Section: Discussionsupporting

confidence: 57%

“…), highlighting the clinical effectiveness of treatment of patients in this cohort. It is well documented that nasal congestion is correlated with restricted lower nasal airflow function in adults with seasonal rhinitis . Key studies have demonstrated that PIFR measurements reflect the severity of nasal signs of rhinitis in a general population sample of young adults .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A novel and well tolerated mite allergoid subcutaneous immunotherapy: evidence of clinical and immunologic efficacy

Roger

Depreux

Jurgens

et al. 2014

Immunity, Inflammation and Disease

View full text Add to dashboard Cite

Allergy to house dust mite is one of the most common causes of allergic rhinitis. A novel tyrosine-adsorbed, modified allergen product, Acarovac Plus, developed for the treatment of perennial mite allergy seeks to address the underlying cause of allergic rhinitis in this instance. One of two dosing regimens may be used, either the Conventional Regimen or the Cluster Regimen. We sought to compare the efficacy and safety of a specific immunotherapy, developed for the treatment of perennial mite allergy, administered under a Conventional and Clustered dosing schedule in patients with persistent allergic rhinitis. Thirty adult patients, between 18 and 65 years old, with allergic rhinitis and/or asthma secondary to hypersensitivity to Dermatophagoides pteronyssinus were administered with either conventional or cluster initial regime, with a final visit one week after the last dose administration. The efficacy to the Conventional and Cluster regimens was measured using a Nasal Challenge Test monitoring clinical symptoms and peak nasal inspiratory flow. Total IgE, serum-specific inmunoglobulins (IgE and IgG4) to Dermatophagoides pteronyssinus and relevant cytokines (IFN-γ, IL-4, IL-5, IL-10 and IL-13) were assessed. A Satisfaction Questionnaire (TSQM) was completed after each patient's final visit. The tolerability of the vaccine was assessed monitoring adverse reactions. No adverse events were recorded in either conventional or cluster regime. The specific Nasal Challenge Test led to a decrease in symptom scores and a significant decrease in mean nasal peak inspiratory flow drop was recorded in both dosing regimen groups. A significant increase in IgG4-specific antibody titres was assessed. No significant changes were observed in concentrations of total IgE, specific IgE or cytokines (IFN-γ, IL-4, IL-5, IL-10 and IL-13). Patients declared themselves most satisfied in relation to “Secondary effects”, with high overall satisfaction in both groups. Cluster and conventional specific immunotherapy resulted in no adverse reaction(s) and led to similar improvements in immunological parameters, clinical efficacy (Nasal Challenge Test) and high overall satisfaction.

show abstract

Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 99%

A novel and well tolerated mite allergoid subcutaneous immunotherapy: evidence of clinical and immunologic efficacy

Roger

Depreux

Jurgens

et al. 2014

Immunity, Inflammation and Disease

View full text Add to dashboard Cite

show abstract

“…In fact, mean PNIF recordings were within the normal range in both groups, demonstrating that nasal airflow was unimpeded. 16,25 This suggests that a process other than physical resistance to airflow in the nasal cavity was responsible for the subjective impression of nasal obstruction in our CRS patients. TS chemoreception was known to relay information about freshness and coolness within the nasal cavity, but Zhao and colleagues were the first to demonstrate that mucosal cooling was the mechanism driving the sensation of patency.…”

Section: Discussionmentioning

confidence: 81%

“…CRS patients rated their sensation of nasal obstruction to be significantly worse than controls, and both groups demonstrated similar mean PNIF measurements. In fact, mean PNIF recordings were within the normal range in both groups, demonstrating that nasal airflow was unimpeded . This suggests that a process other than physical resistance to airflow in the nasal cavity was responsible for the subjective impression of nasal obstruction in our CRS patients.…”

Section: Discussionmentioning

confidence: 99%

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Although inspiratory manoeuvres may cause alar collapse and thus valve insufficiency, and in few cases, when the nose is totally blocked, it is not possible to obtain a measurement , PNIF has some undoubtable hygienic advantages over PNEF . Moreover, it seems that PNIF correlates better with nasal resistances than PNEF .…”

Section: Objective Measurements Of Nasal Airflow and Patencymentioning

confidence: 94%

Measurements of nasal airflow and patency: a critical review with emphasis on the use of peak nasal inspiratory flow in daily practice

Ottaviano

Fokkens

2016

Allergy

120

111

View full text Add to dashboard Cite

Objective measures can be used to assist the clinician to diagnose and treat nasal obstruction and also to quantify nasal obstruction in research. Objective measurements of nasal obstruction are as important as objective measurements of lung function. peak nasal inspiratory flow (PNIF), acoustic rhinometry (AR) and rhinomanometry (RM), with their specific peculiarity, assess different aspects of nasal obstruction. From the studies available in the literature, it seems that these methods roughly correlate with each other and that all of them can be alternatively utilized very well in research as well as in clinical practice. This review describes the various methods that can be used to measure nasal patency, airflow and resistance, mainly peak nasal inspiratory flow, rhinomanometry and acoustic rhinometry. PNIF has been demonstrated to be reproducible and as good an indication of objective nasal patency as formal rhinomanometry and has the advantage to be cheap, simple and suitable for serial measurements and for home use even in the paediatric population. PNIF normative data are available for children, adults and elderly subjects, and the availability of unilateral PNIF normal values allows evaluation of nasal sides separately. Just as in the lower airways, objective and subjective evaluation gives different information that together optimizes the diagnosis and the treatment of our patients. We argue that PNIF should be used regularly in every outpatient clinic that treats patients with nasal obstruction.

show abstract

Evaluation of Peak Nasal Inspiratory Flow as an Objective Method of Measuring Nasal Airflow

Abstract: POSTERSclinical features of ACPs in Japan is very limited. Here, we performed a prospective study to evaluate the prevalence and clinical features of ACPs.

Cited by 23 publications

References 0 publications

A novel and well tolerated mite allergoid subcutaneous immunotherapy: evidence of clinical and immunologic efficacy

A novel and well tolerated mite allergoid subcutaneous immunotherapy: evidence of clinical and immunologic efficacy

The role of trigeminal function in the sensation of nasal obstruction in chronic rhinosinusitis

Measurements of nasal airflow and patency: a critical review with emphasis on the use of peak nasal inspiratory flow in daily practice

Contact Info

Product

Resources

About