Evaluation of paraoxonase-1 enzyme activity and oxidative stress relations in malignant mesothelioma cases

Coşan, Didem Turgut; Ak, Güntülü; Colak, Emine; Dal, Aylin; Öner, Çağrı; Soyocak, Ahu; Çolak, Ertuğrul; Güneş, Hasan Veysi; Metintaş, Muzaffer

doi:10.4103/ejop.ejop_78_19

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“…The endogenous antioxidant paraoxanase-1 (PON1) is a polimorphic calcium-dependent serum enzyme with lipophilic antioxidant property (Çolak et al, 2020). PON1, which is associated with high-density lipoprotein cholesterol (HDL-C) hydrolysis of toxic metabolites found in some insecticides, nerve agents, and esters (Çolak et al, 2020;Draganov & La Du, 2004). PON1 also is involved in hydrolysis of lipid peroxidation.…”

Section: Introductionmentioning

confidence: 99%

Effects of kefir on paraoxanase activity (PON1), total antioxidant status (TAS), total oxidant status (TOS), and serum lipid profiles in smokers and non-smokers

2022

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Some scientific evidence indicates that antioxidant-rich diets may prevent the negative effects of free radicals. In this study, we aimed to evaluate the effects of kefir consumption on paraxonase-1 (PON1) activity, total antioxidant status (TAS), total oxidant status (TOS), and serum lipid parameters in smokers and non-smokers. At baseline, PON1 activity, TAS, and high-density lipoprotein cholesterol (HDL-C) levels were lower (P<0.05, P<0.01, and P<0.05, respectively) whereas TOS, triglyceride (TG), and light-density lipoprotein cholesterol (LDL-C) levels were higher (all P<0.05) in smokers compared to non-smokers. There were no significant differences in total cholesterol (TC) levels between two groups (P>0.05). After 6-week of kefir consumption, PON1 and TAS values were significantly increased in smokers (both P<0.05) and non-smokers (P<0.05 and P<0.01, respectively). Kefir consumption did not have any significant effect on TOS, HDL-C, LDL-C, TC, and TG values both in smokers (all P>0.05) and non-smokers (all P>0.05). Regular consumption of kefir increases the PON1 activity and TAS value in both smokers and non-smokers. It can be concluded that kefir plays an important role in favor of antioxidants in the formation of antioxidant/ oxidant balance in both smokers and non-smokers.

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Section: Introductionmentioning

confidence: 99%