Evaluation of paliperidone on social function in patients with chronic schizophrenia

Gu, Yeunhwa; Peng, Hong; Jing-jing, Dai; Gao, Hui; Yang, Xiang-Hong; Jia-ling, Sheng; Zhang, Chen

doi:10.1136/gpsych-2018-000011

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…Keywords: Potential drug-drug interaction, Adverse drug reaction, Older adults, Psychiatric disorder with pDDIs were included in the analysis. In addition, ADRs were recorded based on the Treatment Emergent Symptom Scale (TESS) [19,20] and the course record recorded by doctors. The TESS has been used in psychiatric settings to assess the severity of ADRs, the link between symptoms and medications, and the measures taken in the form of scores.…”

Section: Data Extraction and Statistical Analysismentioning

confidence: 99%

Clinical significance of potential drug–drug interactions in older adults with psychiatric disorders: a retrospective study

et al. 2022

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Background Polypharmacy increases the risk of potential drug–drug interactions (pDDIs). This retrospective analysis was conducted to detect pDDIs and adverse drug reactions (ADRs) among older adults with psychiatric disorder, and identify pDDIs with clinical significance. Methods A retrospective analysis was carried out based on the medical records of older adults with psychiatric disorders. Data on demographic characteristics, substance abuse, medical history, and medications were extracted. The Lexi-Interact online database was used to detect pDDIs. The minimal clinically important difference (MCID) was set as the change in the Treatment Emergent Symptom Scale (TESS) score between admission and discharge. The median and interquartile ranges were used for continuous variables, and frequencies were calculated for dichotomous variables. Poisson regression was implemented to determine the factors influencing the number of ADR types. The influencing factors of each ADR and the clinical significance of the severity of the ADR were analysed using binary logistic regression. P < 0.05 was considered statistically significant. Results A total of 308 older adults were enrolled, 171 (55.52%) of whom had at least 1 pDDI. Thirty-six types of pDDIs that should be avoided were found, and the most frequent pDDI was the coadministration of lorazepam and olanzapine (55.5%). A total of 26 ADRs induced by pDDIs were identified, and the most common ADR was constipation (26.05%). There was a 9.4 and 10.3% increase in the number of ADR types for each extra medical diagnosis and for each extra drug, respectively. There was a 120% increase in the number of ADR types for older adults hospitalized for 18–28 days compared with those hospitalized for 3–17 days. There was an 11.1% decrease in the number of ADR types for each extra readmission. The length of hospitalization was a risk factor for abnormal liver function (P < 0.05). The use of a large number of drugs was a risk factor for gastric distress (P < 0.05) and dizziness and fainting (P < 0.05). None of the four pDDIs, including coadministrations of olanzapine and lorazepam, quetiapine and potassium chloride, quetiapine and escitalopram, and olanzapine and clonazepam, showed clinical significance of ADR severity (P > 0.05). Conclusions pDDIs are prevalent in older adults, and the rate is increasing. However, many pDDIs may have no clinical significance in terms of ADR severity. Further research on assessing pDDIs, and possible measures to prevent serious ADRs induced by DDIs is needed to reduce the clinical significance of pDDIs.

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Section: Data Extraction and Statistical Analysismentioning

confidence: 99%

Clinical significance of potential drug–drug interactions in older adults with psychiatric disorders: a retrospective study

et al. 2022

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“…The core symptoms of schizophrenia include positive symptoms such as hallucinations and delusions, negative symptoms such as decreased motivation and apathy, cognitive dysfunction, and social dysfunction. Social dysfunction refers to an impaired ability to properly perform daily social activities and maintain one's social life [2], and decreased social functioning has been reported in patients with schizophrenia and mental disorders [3][4][5][6]. Notably, social dysfunction is associated with recurrence [7], decreased activity [8], difficulty in employment/occupation [9], increased medical costs [10], and poor prognosis in schizophrenia patients.…”

Section: Introductionmentioning

confidence: 99%

A Retrospective Study on the Relationship Between Cognitive Function and Social Function in Patients With Schizophrenia

et al. 2022

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Background: Social dysfunction is associated with decreased activity, employment difficulties, and poor prognosis in patients with schizophrenia. Cognitive functions, such as attention and processing speed, have been implicated in the social functions of schizophrenia patients; however, the relationship between cognitive functions and social functions remains unclear. Thus, understanding the factors that influence social functioning can aid the development of therapeutic strategies for schizophrenia. Herein, we retrospectively analyzed factors that influence social functioning in patients with schizophrenia.Methods: Patient background, intelligence quotient (IQ) scores, Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J) scores, the dose of antipsychotic drugs, Positive and Negative Syndrome Scale (PANSS) scores, and the factors influencing each subscale of the Japanese version of the Social Functioning Scale (SFS-J) were evaluated using univariate and multivariate analyses. The Bonferroni correction was applied to evaluate the correlation between each factor in the univariate analysis. In multivariate analysis, independent variables were selected using a stepwise method. In each model, considering the sample size, the maximum number of variables extracted using the stepwise method was set to three. We then calculated the standard partial regression coefficient (standard β) between the SFS-J subscale scores and each factor.Results: Data from 36 patients were analyzed. The average age, ill-ness duration, and total length of hospitalization were 57.8 years, 34.8 years, and 196.7 months, respectively. Of the seven significant correlations with the SFS-J subscale in the univariate analysis, only three were significant in the multivariate analysis model. According to the multivariable model, BACS-J verbal fluency positively correlated with SFS-J withdrawal, interpersonal communication, and employment/occupation. Moreover, BACS-J token motor and educational history were positively correlated with SFS-J recreation and SFS-J employment/occupation, respectively. PANSS scores, IQ scores, and doses of antipsychotic drugs did not show clear associations with SFS-J scores. Conclusions:In conclusion, there were significant correlations between BACS-J subscale scores for cognitive functioning and SFS-J subscale scores for social functioning in patients with schizophrenia.

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“…Defects in social functioning and social skills are often associated with the diagnosis of schizophrenia [4][5][6][7]. In a study conducted in Iran on 208 schizophrenia patients, 95.75% of them had social dysfunction [2,3].…”

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confidence: 99%

Assessing the Validity and Reliability of the Persian Version of the Interpersonal Problem Solving Skills Assessment Tool in Schizophrenia

Nouri

Bakhshi

Abolhasani

2021

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Objective: This study aimed to translate the Assessment of Interpersonal Problem-Solving Skills (AIPSS) into Persian and to evaluate the validity and reliability of the Persian version of AIPSS to use for adults with schizophrenia. Materials & Methods: In this methodological study, the translation process was performed according to the International Quality of Life Assessment (IQOLA) protocol. The face validity of the translated AIPSS was determined based on the opinions of experts and The Content Validity Index (CVI) and Content Validity Ratio (CVR) were also calculated for each item. The Persian version of the test was performed on 52 patients with schizophrenia disorders at Tehran’s Razi Mental Hospital; they were selected using a convenience sampling method. Cronbach’s alpha coefficient was used to evaluate internal consistency. Inter-rater reliability was determined by the Intraclass Correlation Coefficient (ICC). A retest was complete on 15 patients with 2 weeks interval and ICC was used to determine the test-retest reliability. Results: Face validity was confirmed by the experts’ opinions. The Content Validity Ratio (CVR) and the Content Validity Index (CVI) were equal to one for all scenes. Cronbach's alpha coefficient for all scales was ranged between 0.511 and 0.821. The ICC in all scales were more than 0.98 for inter-rater reliability. In calculating test-retest reliability, the ICC for all scales ranged 0.733-0.893. Conclusion: Results show that the Persian version of AIPSS has acceptable face validity, content validity, internal consistency, inter-rater reliability test-retest reliability. Therefore, this instrument can be used in clinical fields and research studies to assess the social skills of Iranian patients with schizophrenia.

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Evaluation of paliperidone on social function in patients with chronic schizophrenia

Cited by 4 publications

References 13 publications

Clinical significance of potential drug–drug interactions in older adults with psychiatric disorders: a retrospective study

Clinical significance of potential drug–drug interactions in older adults with psychiatric disorders: a retrospective study

A Retrospective Study on the Relationship Between Cognitive Function and Social Function in Patients With Schizophrenia

Assessing the Validity and Reliability of the Persian Version of the Interpersonal Problem Solving Skills Assessment Tool in Schizophrenia

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