Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography

Koh, Wui Jin; Bergman, Kenneth S.; Rasey, Janet S.; Peterson, Lanell M.; Evans, Margaret L.; Graham, Michael M.; Grierson, John R.; Lindsley, Karen; Lewellen, T.K.; Krohn, Kenneth A.; Griffin, Thomas W.

doi:10.1016/0360-3016(95)00170-4

Cited by 263 publications

(116 citation statements)

References 24 publications

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“…Uncontrolled local recurrence in the head and neck region can lead to prolonged misery and disfigurement. The results of PET studies of hypoxia imaging in H&N tumours [109][110][111][112] are provocative. A significant correlation between PET hypoxia-tracer uptake and treatment response has been reported.…”

Section: Figurementioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

333

197

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Section: Figurementioning

confidence: 99%

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

MacManus

Nestle

Rosenzweig

et al. 2009

Radiotherapy and Oncology

333

197

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“…Rajendran et al (18) showed the feasibility of this approach using 18 F-FMISO PET to detect tissue hypoxia (corresponding to pO 2 values of ≤3 mm Hg) in imaging studies and showed that 18 F-FMISO uptake was directly related to tissue hypoxia (19). Different tumor/blood and tumor/muscle threshold ratios have been proposed as quantitative criteria for delineating hypoxic tumor volumes (19)(20)(21)(22)(23). To our knowledge, no standard PET criterion for defining hypoxia has yet been established.…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of Intratumor Distribution of 18F-Fluoromisonidazole in Head and Neck Cancer

Nehmeh

Lee

Schröder

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

192

130

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Purpose-Hypoxia is one of the main causes of the failure to achieve local control using radiotherapy. This is due to the increased radioresistance of hypoxic cells. 18 F-fluoromisonidazole ( 18 F-FMISO) positron emission tomography (PET) is a noninvasive imaging technique that can assist in the identification of intratumor regions of hypoxia. The aim of this study was to evaluate the reproducibility of 18 F-FMISO intratumor distribution using two pretreatment PET scans.Methods and Materials-We enrolled 20 head and neck cancer patients in this study. Of these, 6 were excluded from the analysis for technical reasons. All patients underwent an 18 Ffluorodeoxyglucose study, followed by two 18 F-FMISO studies 3 days apart. The hypoxic volumes were delineated according to a tumor/blood ratio ≥1.2. The 18 F-FMISO tracer distributions from the two 18 F-FMISO studies were co-registered on a voxel-by-voxel basis using the computed tomography images from the PET/computed tomography examinations. A correlation between the 18 F-FMISO intensities of the corresponding spatial voxels was derived.Results-A voxel-by-voxel analysis of the 18 F-FMISO distributions in the entire tumor volume showed a strong correlation in 71% of the patients. Restraining the correlation to putatively hypoxic zones reduced the number of patients exhibiting a strong correlation to 46%.Conclusion-Variability in spatial uptake can occur between repeat 18 F-FMISO PET scans in patients with head and neck cancer. Blood data for one patient was not available. Of 13 patients, 6 had well-correlated intratumor distributions of 18 F-FMISO-suggestive of chronic hypoxia. More work is required to identify the underlying causes of changes in intratumor distribution before singletime-point 18 F-FMISO PET images can be used as the basis of hypoxia-targeting intensity-modulated radiotherapy.

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“…3 H-misonidazole was found to bind to hypoxic tissue in spheroids and certain tumours (17,18). Non-invasive imaging of hypoxia in tumours in the intact organism by positron emission tomography (PET) is under continued development and preliminary clinical studies reported binding of a uorinated misonidazole in human solid tumours (19)(20)(21). In a recent study we established a non-invasive method to assess hypoxia in experimental mouse mammary carcinomas by PET scanning using 18 F -uoromisonidazole ([ 18 F ]F M ISO).…”

mentioning

confidence: 99%

Assessment of Hypoxia in Experimental Mice Tumours by [ 18 F] Fluoromisonidazole PET and pO 2 Electrode Measurements

et al. 2002

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Evaluation of oxygenation status during fractionated radiotherapy in human nonsmall cell lung cancers using [F-18]fluoromisonidazole positron emission tomography

Cited by 263 publications

References 24 publications

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Use of PET and PET/CT for Radiation Therapy Planning: IAEA expert report 2006–2007

Reproducibility of Intratumor Distribution of 18F-Fluoromisonidazole in Head and Neck Cancer

Assessment of Hypoxia in Experimental Mice Tumours by [ 18 F] Fluoromisonidazole PET and pO 2 Electrode Measurements

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