Evaluation of oxygen sensitivity of hyperpolarized helium imaging for the detection of pulmonary ischemia

Abstract

These results demonstrate that pO and R, as measured by the T1 decay of HP (3) He, are sensitive to pulmonary ischemia in rats, confirming the findings in studies performed in large animal models of pulmonary ischemia.

High spatial resolution hyperpolarized 3He MRI of the rodent lung using a single breath X‐centric gradient‐recalled echo approach

“…In particular, HP 3 He imaging has revealed heterogeneous airway obstruction in asthma patients as well as ventilation heterogeneity of lung parenchyma in chronic obstructive pulmonary disease patients . Specifically, HP 3 He gas MRI of small animal models of lung disease is a promising method to quantify airway and ventilation abnormalities associated with airway narrowing, bronchoconstriction, and subsequent bronchodilation . However, the signal‐to‐noise ratio (SNR) of HP gases is limited by the nonrenewable nature of the magnetization, requiring rapid breath‐hold imaging with a minimal number of small flip‐angle radiofrequency (RF) pulses.…”

High Resolution3He Pulmonary MRI

“…Our main focus will be on 3 He gas MRI of small animal models of lung disease [20,21], as it is a promising tool to quantify airway and ventilation abnormalities associated with bronchoconstriction, airway narrowing, and subsequent bronchodilation [22,23]. Small animal 3 He lung MRI normally assumes high spatial resolution imaging (<500 μm [22]) in order to obtain acceptable images for the quantitative analysis and visualization of rodent airways and lung parenchyma.…”