Evaluation of oxidative stress markers in oral lichen planus

Rekha, VR; Sunil, S; Ravindran, Rathy

doi:10.4103/jomfp.jomfp_19_17

Cited by 26 publications

(19 citation statements)

References 26 publications

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“…In the study by Rekha et al [30], the activity of GPx determined for 40 patients with OLP, the levels of salivary GPx (0.06 ± 0.03) in patients with OLP were significantly lower than in controls, which is in line with our results. Likewise, in the study by Totan et al [14], GPx activity was similar to that in our study.…”

Section: Discussionsupporting

confidence: 92%

“…In none of the cited studies was there an addition of butylated hydroxytoluene (BHT) to limit in vitro lipid or protein peroxidation. Furthermore, Rekha et al [30] provided neither the units in which the results were calculated nor the literature references for the measurement method, despite the fact that the authors used the spectrophotometric method and sample to reagent ratios similar to ours [30].…”

Section: Discussionmentioning

confidence: 99%

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The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Darczuk

Krzyściak

Bystrowska

et al. 2019

Oxidative Medicine and Cellular Longevity

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The diagnosis of oral lichen planus (OLP) is based on clinical examination and histopathological criteria. Noninvasive diagnostics of saliva may be considered as a confirmation of OLP diagnosis and a potential alternative to an invasive method. The objective of the present study was to evaluate the relationship between the level of tyrosine (Tyr) as well as antioxidants like uric acid (UA) and glutathione peroxidase (GPx) activity in the saliva of patients with OLP in comparison with the control group (healthy subjects without any oral changes). A total of 40 patients with OLP and 40 healthy volunteers were selected for the study based on the modified WHO diagnostic (clinical and histopathological) criteria. High-performance liquid chromatography (HPLC) was performed for Tyr concentration, while GPx activity and uric acid levels were determined by a colorimetric method. The concentrations of Tyr, UA, and GPx activity were statistically lowered in OLP patients compared to the control group. All examined parameters correlated strongly and positively with each other. Mean values of salivary UA concentrations differed between the groups of OLP patients (reticular and erosive forms) and controls (206.66 vs. 196.54 vs. 218.49 μmol/L, respectively, p = 0.001). A similar trend was demonstrated in salivary Tyr concentration which differed statistically between the study and control groups (0.08 vs. 0.07 vs. 0.13 μmol/L, respectively, p = 0.001). Determining of a relationship between the concentrations of Tyr, UA, and GPx activity may be useful in the prognosis of OLP. The HPLC method may be employed, as an additional noninvasive diagnostic procedure to screen OLP patients, during the routine diagnostics of salivary biochemical parameters such as aromatic amino acids.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Darczuk

Krzyściak

Bystrowska

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…There is evidence that a cell-mediated autoimmune reaction in which CD4 + and CD8 + T lymphocytes induce the apoptosis of epithelial basal cells may be involved (5). It has also been suggested that oxidative stress may be of importance in the pathogenesis of OLP (6). Studies have shown a correlation between decreased serum levels of an important antioxidant, uric acid, with exacerbation of the LP state compared with healthy controls and patients with LP in the remission phase (7).…”

Section: Evaluation Of Depression Anxiety and Stress Levels In Patiementioning

confidence: 99%

Evaluation of depression, anxiety and stress levels in patients with oral lichen planus

et al. 2019

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The pathogenesis of oral lichen planus (OLP) remains to be fully elucidated; however, certain psychoneurological factors may influence the onset and exacerbation of OLP. The aim of the present study is to evaluate the intensity of negative emotions in patients with OLP. A cross-sectional, questionnairebased study was performed. The sample consisted of 52 subjects, comprising 26 patients with OLP (OLP group) and 26 controls (CTRL group). The Depression Anxiety Stress Scale 21 (DASS-21) was used for psychometric evaluation. The patients were also asked about their attitude toward the disease, treatment, and interference of the disease on daily life. The mean level of depression was 12.54 ± 6.6 in the OLP group and 7.69 ± 5.22 in the CTRL group (P = 0.006). The mean level of anxiety was 11.15 ± 7.95 in the OLP group and 6.62 ± 4.86 in the CTRL group (P = 0.018). The mean stress levels were 8.69 ± 7.06 and 3.85 ± 3.18 in the OLP and CTRL groups, respectively (P = 0.003). Severe and very severe scores of depression and very severe scores of anxiety and stress were present in the OLP group, whereas these emotions were normal in the majority of controls. Depression, stress, and anxiety may be involved in the pathogenesis and course of OLP.

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“…Short-term oxidative stress might also be meaningful in prevention from aging (73). However, oxidative stress is also involved in the development of various diseases including cancers (74–79). Severely oxidative stresses even cause cell death, apoptosis, necrosis, cell migration, fibrosis, and angiogenesis.…”

Section: Mitochondrial Dysfunction-mediated Oxidative Stressmentioning

confidence: 99%

Mitochondrial Dysfunction Pathway Networks and Mitochondrial Dynamics in the Pathogenesis of Pituitary Adenomas

Zhan

2019

Front. Endocrinol.

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Mitochondrion is a multi-functional organelle, which is associated with various signaling pathway networks, including energy metabolism, oxidative stress, cell apoptosis, cell cycles, autophagy, and immunity process. Mitochondrial proteins have been discovered to modulate these signaling pathway networks, and multiple biological behaviors to adapt to various internal environments or signaling events of human pathogenesis. Accordingly, mitochondrial dysfunction that alters the bioenergetic and biosynthetic state might contribute to multiple diseases, including cell transformation and tumor. Multiomics studies have revealed that mitochondrial dysfunction, oxidative stress, and cell cycle dysregulation signaling pathways operate in human pituitary adenomas, which suggest mitochondria play critical roles in pituitary adenomas. Some drugs targeting mitochondria are found as a therapeutic strategy for pituitary adenomas, including melatonin, melatonin inhibitors, temozolomide, pyrimethamine, 18 beta-glycyrrhetinic acid, gossypol acetate, Yougui pill, T-2 toxin, grifolic acid, cyclosporine A, dopamine agonists, and paeoniflorin. This article reviews the latest experimental evidence and potential biological roles of mitochondrial dysfunction and mitochondrial dynamics in pituitary adenoma progression, potential molecular mechanisms between mitochondria and pituitary adenoma progression, and current status and perspectives of mitochondria-based biomarkers and targeted drugs for effective management of pituitary adenomas.

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Evaluation of oxidative stress markers in oral lichen planus

Cited by 26 publications

References 26 publications

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

The Relationship between the Concentration of Salivary Tyrosine and Antioxidants in Patients with Oral Lichen Planus

Evaluation of depression, anxiety and stress levels in patients with oral lichen planus

Mitochondrial Dysfunction Pathway Networks and Mitochondrial Dynamics in the Pathogenesis of Pituitary Adenomas

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