Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence

Dries, Samuel Selbach; Seibert, Bruna Scherer; Bastiani, Marcos Frank; Linden, Rafael; Perassolo, Magda Susana

doi:10.1080/01480545.2020.1780251

Cited by 6 publications

(8 citation statements)

References 37 publications

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“…The main etiology of alcohol dependence includes genetic and environmental factors, with genetic factors accounting for 40–60% ( 11 ). Most studies have been conducted on immune inflammation ( 12 , 13 ), oxidative stress ( 14 ), metabolism ( 15 ), and apoptosis of brain cells ( 16 ) in patients with alcohol dependence. Despite ongoing studies on the pathology, causes, and risk factors of this disease, an appropriate treatment regimen has not yet been determined.…”

Section: Discussionmentioning

confidence: 99%

Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database

Zhang

Wang²,

Huang

et al. 2022

Front. Psychiatry

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Background: Alcohol dependence is an overall health-related challenge; however, the specific mechanisms underlying alcohol dependence remain unclear. Serine proteinase inhibitor A3 (SERPINA3) plays crucial roles in multiple human diseases; however, its role in alcohol dependence clinical practice has not been confirmed.Methods: We screened Gene Expression Omnibus (GEO) expression profiles, and identified differentially expressed genes (DEGs). Protein-protein interaction (PPI) networks were generated using STRING and Cytoscape, and the key clustering module was identified using the MCODE plugin. SERPINA3-based target microRNA prediction was performed using online databases. Functional enrichment analysis was performed. Fifty-eight patients with alcohol dependence and 20 healthy controls were recruited. Clinical variables were collected and follow-up was conducted for 8 months for relapse.Results:SERPINA3 was identified as a DEG. ELANE and miR-137 were identified after PPI analysis. The enriched functions and pathways included acute inflammatory response, response to stress, immune response, and terpenoid backbone biosynthesis. SERPINA3 concentrations were significantly elevated in the alcohol dependence group than in healthy controls (P < 0.001). According to the median value of SERPINA3 expression level in alcohol dependence group, patients were divided into high SERPINA3 (≥2677.33 pg/ml, n = 29) and low SERPINA3 groups (<2677.33 pg/ml, n = 29). Binary logistic analysis indicated that IL-6 was statistically significant (P = 0.015) Kaplan-Meier survival analysis did not indicate any difference in event-free survival between patients with low and high SERPINA3 levels (P = 0.489) after 8 months of follow-up. Receiver characteristic curve analysis revealed that SERPINA3 had an area under the curve of 0.921 (P < 0.0001), with a sensitivity and specificity of 93.1 and 80.0%, respectively. Cox regression analysis revealed that aspartate transaminase level was a negative predictor of relapse (β = 0.003; hazard ratio = 1.003; P = 0.03).Conclusions:SERPINA3 level was remarkably elevated in patients with alcohol dependence than healthy controls, indicating that SERPINA3 is correlated with alcohol dependence. However, SERPINA3 may not be a potential predictive marker of relapse with patients in alcohol dependence.

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Section: Discussionmentioning

confidence: 99%

Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database

Zhang

Wang²,

Huang

et al. 2022

Front. Psychiatry

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“…Research has shown that a detoxification period of two weeks positively impacted MDA activity, which was reduced (8,23) and was not different from the control in some individuals (10,11). However, Wu et al (27) and Dries et al (28) did not find a difference in this biomarker before and after dependence treatment.…”

Section: Discussionmentioning

confidence: 94%

“…In some studies, detoxification did not cause a significant alteration in SOD concentrations ( 10 , 11 , 27 , 28 ). Others found decreased concentration compared to values at hospital admission ( 8 , 29 ).…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of oxidative stress markers in ethanol users

Moraes

Dries

Seibert

et al. 2023

Braz J Med Biol Res

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Ethanol is a central nervous system depressant that is widely consumed worldwide. When consumed chronically, it may have several consequences to the organism, such as oxidative stress. Ethanol metabolism increases the production of oxidant molecules and its consumption may cause changes in enzymatic and non-enzymatic systems that maintain cellular homeostasis. The activity of endogenous enzymes and lipid peroxidation are altered in alcohol consumers. Therefore, this study aimed to evaluate oxidative stress parameters in ethanol users compared to a control group. For that, the activity of the enzymes superoxide dismutase, catalase, and glutathione peroxidase, the ferric reducing/antioxidant power (FRAP), and malondialdehyde were evaluated. The influence of the amount of ethanol consumed on the analyzed parameters was also verified. The group of alcohol users consisted of 52 volunteers, 85% male and 15% female, with a mean age of 41±13 years. The control group consisted of 50 non-drinkers, 40% male and 60% female, with a mean age of 50±10 years. There was a significant difference in superoxide dismutase (P<0.001) and malondialdehyde (P=0.007) measurements between groups, as both parameters were increased in the group of ethanol users. Because of the higher amount of ethanol consumed, there was an increase of the catalase activity parameters and gradual reduction of FRAP. Thus, the ethanol-consuming participants were most likely under oxidative stress.

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“…A study comparing oxidative stress in AD patients during hospitalization showed lower SOD levels at discharge. In comparison, GPX and ferric reducing antioxidant power presented higher levels that indicate reversion of alcohol effects over oxidative stress parameters [ 51 ]. Another investigation of the total antioxidant activity of human serum blood carried out by voltametric, amperometric, and chemiluminescent methods revealed that the serum total antioxidant activity of patients with AD was lower than the total antioxidant activity of healthy donors [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

2022

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Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

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Evaluation of oxidative stress biomarkers and liver and renal functional parameters in patients during treatment a mental health unit to treat alcohol dependence

Cited by 6 publications

References 37 publications

Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database

Exploration of the Role of Serine Proteinase Inhibitor A3 in Alcohol Dependence Using Gene Expression Omnibus Database

Evaluation of oxidative stress markers in ethanol users

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

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