Evaluation of oxidative stress and δ-aminolevulinate dehydratase activity in twin pregnancies

Jantsch, Letícia Bigolin; Lucca, Leidiane de; Dorneles, Bárbara Nicoli; Konopka, Cristine Kolling; Gonçalves, Thissiane de Lima

doi:10.1080/14767058.2019.1568980

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…Gür et al reported that increased levels of malondialdehyde (MDA), a marker for lipid peroxidation which is usually generated by ROS, and decreased antioxidant ability of vitamins A and E were observed in ewes with twin pregnancies compared with those with singleton pregnancies [ 124 ]. The same result was noted in humans with an increase in MDA levels in twin pregnancies compared with singletons [ 125 ]. In sFGR MC twin pregnancies, the indicators of OS such as MDA, 8-hydroxydeoxyguanosine (8-OHdG), and COX2 were elevated in the placental sector of the growth-restricted fetus [ 111 , 126 ].…”

Section: Ossupporting

confidence: 80%

Molecular Mechanisms Underlying Twin-to-Twin Transfusion Syndrome

Kajiwara

Ozawa

Wada

et al. 2022

Cells

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Twin-to-twin transfusion syndrome is a unique disease and a serious complication occurring in 10–15% of monochorionic multiple pregnancies with various placental complications, including hypoxia, anemia, increased oxidative stress, and ischemia-reperfusion injury. Fetoscopic laser photocoagulation, a minimally invasive surgical procedure, seals the placental vascular anastomoses between twins and dramatically improves the survival rates in twin-to-twin transfusion syndrome. However, fetal demise still occurs, suggesting the presence of causes other than placental vascular anastomoses. Placental insufficiency is considered as the main cause of fetal demise in such cases; however, little is known about its underlying molecular mechanisms. Indeed, the further association of the pathogenic mechanisms involved in twin-to-twin transfusion syndrome placenta with several molecules and pathways, such as vascular endothelial growth factor and the renin–angiotensin system, makes it difficult to understand the underlying pathological conditions. Currently, there are no effective strategies focusing on these mechanisms in clinical practice. Certain types of cell death due to oxidative stress might be occurring in the placenta, and elucidation of the molecular mechanism underlying this cell death can help manage and prevent it. This review reports on the molecular mechanisms underlying the development of twin-to-twin transfusion syndrome for effective management and prevention of fetal demise after fetoscopic laser photocoagulation.

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Section: Ossupporting

confidence: 80%

Molecular Mechanisms Underlying Twin-to-Twin Transfusion Syndrome

Kajiwara

Ozawa

Wada

et al. 2022

Cells

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“…The most recent of the retrieved articles, a study by Jantsch et al, was the only one that focused on a problem other than deficiency anemia or calcium and phosphate metabolism. Jantsch et al associated lowered levels of vitamin C in twin pregnancies with greater consumption related to the increased production of free radicals in this type of pregnancy [57]. Similar reports were previously only available for animal models [60].…”

Section: Main Discussionmentioning

confidence: 66%

“…Jantsch et al, who studied oxidative stress in twin pregnancies, proved that the level of vitamin C was significantly lower in twin than in singleton pregnancies. This was found to be accompanied by higher levels of thiobarbituric acid reactive substances, which are used for the detection of lipid peroxidation and the assessment of the intensification of oxidative stress phenomena [57].…”

Section: Other Studied Micronutrientsmentioning

confidence: 99%

“…The systematic literature search retrieved 12 articles and 1 series of publications (four articles) [42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57]. They included 830 participants from eight countries, predominantly with twin pregnancies (96%).…”

Section: Characteristics Of the Retrieved Studiesmentioning

confidence: 99%

“…Only one eligible article identified other micronutrients [57]. Jantsch et al, who studied oxidative stress in twin pregnancies, proved that the level of vitamin C was significantly lower in twin than in singleton pregnancies.…”

Section: Other Studied Micronutrientsmentioning

confidence: 99%

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Micronutrients in Multiple Pregnancies—The Knowns and Unknowns: A Systematic Review

Zgliczyńska

Kosińska-Kaczyńska

2021

Nutrients

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Maternal diet and nutritional status are of key importance with regard to the short- and long-term health outcomes of both the mother and the fetus. Multiple pregnancies are a special phenomenon in the context of nutrition. The presence of more than one fetus may lead to increased metabolic requirements and a faster depletion of maternal macro- and micro- nutrient reserves than in a singleton pregnancy. The aim of this systematic review was to gather available knowledge on the supply and needs of mothers with multiple pregnancies in terms of micronutrients and the epidemiology of deficiencies in that population. It was constructed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA). The authors conducted a systematic literature search with the use of three databases: PubMed/MEDLINE, Scopus and Embase. The last search was run on the 18 October 2020 and identified 1379 articles. Finally, 12 articles and 1 series of publications met the inclusion criteria. Based on the retrieved studies, it may be concluded that women with multiple pregnancies might be at risk of vitamin D and iron deficiencies. With regard to other microelements, the evidence is either inconsistent, scarce or absent. Further in-depth prospective and population studies are necessary to determine if nutritional recommendations addressed to pregnant women require adjustments in cases of multiple gestations.

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