Evaluation of oxidative status in short-term exercises of adolescent athletes

Kürkçü, Recep; Çakmak, Aslıhan; Zeyrek, Dost; Ataş, Ali; Karacabey, Kürşat; Yamaner, Faruk

doi:10.5604/20831862.919350

Cited by 4 publications

(7 citation statements)

References 28 publications

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“…From the included studies, 5 have a mean age for young athletes below 14 years [16,[24][25][26][27]. Moreover, twenty-two out of the 27 included studies are characterised as uncontrolled trials (UCTs) [9,16,24,25,[28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] and five studies as control trials (CTs) [26,27,[46][47][48].…”

Section: Literature Search Resultsmentioning

confidence: 99%

“…In most published investigations, greater levels of lipid peroxidation have been mentioned after a short period of exercise or shortly after a performance assessment. However, a few studies found no noticeable changes [ 18 , 34 , 42 , 47 – 49 ], and a diminished level of lipid peroxidation was reported in two studies [ 45 , 52 ]. Increased TBARS or MDA concentrations have been revealed in young soccer players after a sequence of repeated sprints or a Loughborough Intermittent Shuttle Test [ 30 , 49 ], in long-distance runners after culmination of a maximal test [ 26 , 46 ], in rowers following a maximal simulated test [ 35 ], in swimming after performing different sets (i.e.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, TAC increased immediately at the end of the exercise in all groups in track and field (young athletes and controls) conducted at baseline testing [ 26 ]. In comparison, the antioxidant capacity declined in basketball after the completion of a circuit program [ 34 ], in handball after a maximal trial on the bike [ 9 ], and after a Loughborough Intermittent Shuttle Test in soccer players [ 49 ]. The total antioxidant capacity (T-AOC) remained stable following a 21-km race, at the beginning and end of a practice period [ 8 ], and regular soccer training [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

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Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis

2020

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Background: Several studies have highlighted the substantial role of the athlete's redox and inflammation status during the training process. However, many factors such as differences in testing protocols, assays, sample sizes, and fitness levels of the population are affecting findings and the understanding regarding how exercise affects related biomarkers in adolescent athletes. Objectives: To search redox homeostasis variables' and inflammatory mediators' responses in juvenile athletes following short-or long-term training periods and examine the effect size of those variations to training paradigms. Methods: A PRISMA-compliant systematic review and meta-analysis were conducted. The entire content of PubMed (MEDLINE), Scopus, and Science Direct were systematically searched until December 2019. Studies with outcomes including (1) a group of adolescent athletes from any individual or team sport, (2) the assessment of redox and/or inflammatory markers after a short-(training session or performance testing) or longer training period, and (3) variables measured in blood were retained. The literature search initially identified 346 potentially relevant records, of which 36 studies met the inclusion criteria for the qualitative synthesis. From those articles, 27 were included in the quantitative analysis (meta-analysis) as their results could be converted into common units. Results: Following a short training session or performance test, an extremely large increase in protein carbonyls (PC) (ES 4.164; 95% CI 1.716 to 6.613; Z = 3.333, p = 0.001), a large increase in thiobarbituric acid reactive substances (TBARS) (ES 1.317; 95% CI 0.522 to 2.112; Z = 3.247, p = 0.001), a large decrease in glutathione (GSH) (ES − 1.701; 95% CI − 2.698 to − 0.705; Z = − 3.347, p = 0.001), and a moderate increase of total antioxidant capacity (TAC) level (ES 1.057; 95% CI − 0.044 to 2.158; Z = 1.882, p = 0.060) were observed. Following more extended training periods, GSH showed moderate increases (ES 1.131; 95% CI 0.350 to 1.913; Z = 2.839, p = 0.005) while TBARS displayed a small decrease (ES 0.568; 95% CI − 0.062 to 1.197; Z = 1.768, p = 0.077). Regarding cytokines, a very large and large increase were observed in IL-6 (ES 2.291; 95% CI 1.082 to 3.501; Z = 3.713, p = 0.000) and IL-1 receptor antagonist (ra) (ES 1.599; 95% CI 0.347 to 2.851; Z = 2.503, p = 0.012), respectively, following short-duration training modalities in juvenile athletes.

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Section: Literature Search Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis

2020

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“…Few studies investigated changes in human prooxidant-antioxidant balance following anaerobic exercise [ 26 ]. Most of these studies either involved only men [ 11 , 19 – 21 , 27 – 29 ] or did not take sex into consideration during data analysis [ 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in Non-Enzymatic Antioxidants in the Blood Following Anaerobic Exercise in Men and Women

et al. 2015

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PurposeThe aim of this study was to compare changes in total oxidative status (TOS), total antioxidative capacity (TAC) and the concentration of VitA, VitE, VitC, uric acid (UA), reduced (GSH) and oxidized glutathione (GSSG) in blood within 24 hours following anaerobic exercise (AnEx) among men and women.Methods10 women and 10 men performed a 20-second bicycle sprint (AnEx). Concentrations of oxidative stress indicators were measured before AnEx and 3, 15 and 30 minutes and 1 hour afterwards. UA, GSH and GSSH were also measured 24 hours after AnEx. Lactate and H+ concentrations were measured before and 3 minutes after AnEx.ResultsThe increase in lactate and H+ concentrations following AnEx was similar in both sexes. Changes in the concentrations of all oxidative stress indicators were significant and did not differ between men and women. In both sexes, TOS, TAC, TOS/TAC and VitA and VitE concentrations were the highest 3 minutes, VitC concentration was the highest 30 minutes, and UA concentration was the highest 1 hour after AnEx. GSH concentration was significantly lower than the initial concentration from 15 minutes to 24 hour after AnEx. GSSG concentration was significantly higher, while the GSH/GSSG ratio was significantly lower than the initial values 1 hour and 24 hour after AnEx.ConclusionsWith similar changes in lactate and H+ concentrations, AnEx induces the same changes in TAC, TOS, TOS/TAC and non-enzymatic antioxidants of low molecular weight in men and women. Oxidative stress lasted at least 24 hours after AnEx.

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“…The levels of TAS and TOS were measured using an auto analyzer (Olympus AU680; Beckman Coulter, Miami, FL, USA). The ratio of the TOS level to the TAS level was calculated as OSI, using the formula: OSI (arbitrary unit)=[TOS (mmol H 2 O 2 equivalent/L)/TAS (mmol Trolox equivalent/L)/100] [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

The Evaluation of Exogenous Melatonin Administration in Supraspinatus Overuse Tendinopathy in an Experimental Rat Model

Kocadal

Pepe

Akyürek

et al. 2019

Clin Shoulder Elbow

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Background: Increased oxidative stress and inflammation play a critical role in the etiopathogenesis of chronic tendinopathy. Melatonin is an endogenous molecule that exhibits antioxidant and anti-inflammatory activity. The aim of this study was to evaluate the biochemical and histopathological effects of exogenous melatonin administrations in supraspinatus overuse tendinopathy.Methods: Fifty rats were divided into the following four groups: cage activity, melatonin treatment, corticosteriod therapy, and control. Melatonin (10 mg/kg, intraperitoneal; twice a day) and triamcinolone (0.3 mg/kg, subacromial; weekly) were administered to the treatment groups after the overuse period. Biochemical and histopathological evaluations were performed on serum samples and biopsies obtained from rats. Plasma inducible nitric oxide synthase (iNOS), vascular endothelial growth factor (VEGF), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels were evaluated biochemically.Results: The TAS, TOS, OSI, iNOS, and VEGF values were significantly lower than the pre-treatment levels in rats receiving exogenous melatonin treatment (3 or 6 weeks) (<i>p</i><0.05). TOS, iNOS, VEGF, and OSI values after 3 weeks of triamcinolone administration, and TOS, VEGF, and OSI levels after 6 weeks of triamcinolone application, were significantly lower than the pre-treatment levels (<i>p</i><0.05).Conclusions: Exogenous melatonin application in overuse tendinopathy reduces oxidative stress and inflammation. Melatonin might be an alternative potential molecule to corticosteroids in the treatment of chronic tendinopathy.

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Evaluation of oxidative status in short-term exercises of adolescent athletes

Cited by 4 publications

References 28 publications

Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis

Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis

Changes in Non-Enzymatic Antioxidants in the Blood Following Anaerobic Exercise in Men and Women

The Evaluation of Exogenous Melatonin Administration in Supraspinatus Overuse Tendinopathy in an Experimental Rat Model

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