Evaluation of oxidative/nitrative stress and uterine artery pulsatility index in early pregnancy

Abstract

IntroductionIncreased oxidative/nitrative stress is characteristic not only in pathologic, but also in healthy pregnancy. High uterine artery pulsatility index (UtAPI) at the end of the first trimester is associated with altered placentation and elevated risk for adverse pregnancy outcomes. We aimed to examine the relationship of systemic oxidative/nitrative stress and uterine artery pulsatility index in the first trimester and their correlation to pregnancy outcomes.Material and methodsHealthy pregnant women were recruited at 12–13th gestational week ultrasound examination; UtAPI was determined by color Doppler ultrasound. Patients were divided into high (UtAPI ≥ 2.3) (n = 30) and low (n = 31) resistance groups, and pregnancies were followed until labor. Systemic oxidative/nitrative stress was estimated by measuring total peroxide level, total antioxidant capacity and nitrotyrosine level.ResultsPlasma total peroxide level was significantly lower (2,510 ± 39 µM vs. 2,285 ± 59 µM), total antioxidant capacity was higher (781 ± 16 mM CRE vs. 822 ± 13 mM CRE) in the high UtAPI group, which were accompanied by lower birth weight (3,317 ± 64 vs. 3,517 ± 77 g, P < 0.05). Plasma total peroxide level showed a negative correlation (by Pearson) to UtAPI (P < 0.01) and positive correlation to birth weight (P < 0.05).ConclusionsAccording to our results, lower systemic oxidative stress showed correlation with high UtAPI measured between the 12–13th weeks of gestation. We also found significant differences in the birth weight of healthy newborns; therefore it is worth examining this relationship in pathological pregnancies.

Markers of Oxidative Stress in Obstetrics and Gynaecology—A Systematic Literature Review

“…The rest of the markers were researched in either one or two studies: 8-isoprostane ( n = 1), 8-OHdG ( n = 2), total peroxide ( n = 1), nitrotyrosine ( n = 1), 8-iso-prostaglandin F2α ( n = 2), 8-epiprostaglandin F2-α ( n = 1), prostaglandin F2α ( n = 1), thiol ( n = 1), disulphide ( n = 1), TOS ( n = 1), TAS ( n = 1), DNA damage in blood leukocytes ( n = 1), CAT ( n = 2), γ-glutamyl transferase ( n = 1), hs-CRP ( n = 1), GSH ( n = 1), NO ( n = 1), carbonyl proteins ( n = 1), superoxide anion expressed as reduced nitroblue tetrazolium ( n = 1), aldehyde dehydrogenase ( n = 1), GST ( n = 1), soluble fms-like tyrosine kinase-1 ( n = 1), and placental growth factor ( n = 1) [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 ].…”

Analysis of the uterine artery pulsatility index on the day of endometrial transformation and pregnancy outcomes of patients undergoing frozen–thawed embryo transfer

“…The uterine artery PI is currently the most commonly used indicator that can best reflect the blood flow parameters of the uterine artery ( 6 – 9 ). In this study, when the mean PI values of the clinical pregnancy group and the nonclinical pregnancy group were compared, no statistical significance was observed.…”

Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies

“…Accordingly, increased circulating levels of biomarkers of oxidative stress were shown to associate with multiple agerelated diseases, including cancer, diabetes mellitus [21], neurodegenerative diseases, and cardiovascular diseases, as Oxidative Medicine and Cellular Longevity well as pathological conditions characterized by ongoing inflammatory processes [37,38]. On another note, nitrative stress-imposed by reactive derivatives of NO-contributes to a plethora of pathophysiological processes as well as aging [7,[39][40][41]. This study also found that concentrations of urinary biomarkers of oxidative stress varied considerably in older individuals.…”