Evaluation of outcome prediction and disease extension by quantitative 2-deoxy-2-[18F] fluoro-d-glucose with positron emission tomography in patients with small cell lung cancer

Arslan, Nuri; Tuncel, Murat; Kuzhan, Okan; Alagöz, Engin; Budakoğlu, Burçin; Özet, Ahmet; Özgüven, Mehmet Ali

doi:10.1007/s12149-011-0478-y

Cited by 51 publications

(36 citation statements)

References 18 publications

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“…If a 50% threshold is implemented, the use of TLG rather than volume may be justified on the basis of a significant variability difference. This suggestion is supported by literature data on patients with small cell lung cancer and non-small cell lung cancer (4,7). For all thresholds, the fact that both TLG and volume variability were greater than SUVmean variability (Fig.…”

Section: Discussion Tlg Variabilitysupporting

confidence: 85%

Variability of Total Lesion Glycolysis by 18F-FDG-Positive Tissue Thresholding in Lung Cancer

Laffon

Clermont

Lamare

et al. 2013

Journal of Nuclear Medicine Technology

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The aim of this work was to assess the variability of total lesion glycolysis (TLG) measurements in lung cancer patients, obtained with fixed percentages of the maximum standardized uptake value (SUVmax) thresholds. Methods: Thirteen lesions (10 patients) were analyzed in 10 successive 2.5-min frames of an 18 F-FDG PET dynamic acquisition obtained between 60 and 110 min after injection. 18 F-FDG-positive lesion volume, associated average SUV (SUVmean), and TLG (volume · SUVmean) were assessed in each frame using thresholds of 40%, 50%, 60%, 70%, and 80%. For each threshold, the average relative SD of TLG, leading to relative measurement error and repeatability, was calculated over the lesion series. The dependence of TLG variability on volume and SUVmean variability was also assessed. Results: The average relative SD of TLG correlated strongly with threshold: 1.0866 · exp(0.0472 · threshold) (r 5 0.999; P , 0.01). For the 40% threshold, average TLG over the series was 225.9 g (range, 41.7-1,086.3), relative measurement error and repeatability were 14.5%-20.4% (95% confidence interval), and no significant difference was found between TLG and volume variability. For the other thresholds, TLG variability was significantly lower or greater than volume or SUVmean variability, respectively. Conclusion: In current clinical practice, a formula allows quick estimation of TLG variability for any percentage of the SUVmax threshold: the higher the threshold the greater the TLG variability.

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Section: Discussion Tlg Variabilitysupporting

confidence: 85%

Variability of Total Lesion Glycolysis by 18F-FDG-Positive Tissue Thresholding in Lung Cancer

Laffon

Clermont

Lamare

et al. 2013

Journal of Nuclear Medicine Technology

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“…Arslan et al [16] found that total lesion glycolysis (SUV max > 50%) was the only quantitative PET parameter that could predict survival in patients with SCLC (p = 0.027).…”

Section: Discussionmentioning

confidence: 99%

Pretreatment PET/CT Standardized Uptake Values Play a Role in Predicting Response to Treatment and Survival in Patients with Small Cell Lung Cancer

Dinc

Aydın²,

Odabaş³

et al. 2016

Oncol Res Treat

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Background: We investigated the role of standardized uptake values (SUVs) of the primary tumor in small cell lung cancer (SCLC) patients. Patients and Methods: The relationship between SUV and response to treatment was investigated using receiver operating characteristic (ROC) curve analysis, and the efficient cut-off value for detecting response to treatment was determined. The effects of SUV on response to treatment and survival were investigated. Results: 90 patients with a median age of 58 years (range 39-83 years) were included. Median follow-up was 11 months. The suitable cut-off SUV for determination of response was found to be 10 in ROC analysis. The sensitivity and specificity of this value were 85.7% (95% confidence interval (95% CI) 63-96) and 61.8% (95% CI 49-73) (area under the curve 0.783; p = 0.0001), respectively. The overall objective response rate in patients with involvement above the cut-off value was 93.3% compared to 59.1% in those with involvement below the cut-off value (p < 0.0001). In uni- and multivariate analysis, favorable effects of limited-stage disease on response to treatment were established (p < 0.05). The effect of an SUV higher than the cut-off value on progression-free survival was borderline (p = 0.085). Conclusion: These data may contribute to identifying prognostic disease characteristics and response to treatment.

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“…Diğer bir çalışmada, konvansiyonel evreleme yöntemleri ile sınırlı hastalık tespit edilen hastalarda FDG-PET/BT eklenerek yeniden yapılan evrelemede hastaların %8,3-9,5'da yaygın hastalık evresinde olduğu görülmüştür (72,73). Arslan ve ark FDG-PET/BT ve BT ile yapılan evrelemenin doğruluğu-nu ve genel sağ kalım ile ilişkisini değerlendirmişlerdir (74). BT ile yapılan evreleme ile karşılaştırıldığında 25 hastanın 9'unda evrenin yükseldiği (%36) ve 2 hastada ise evrenin azaldığı (%8) bulunmuştur.…”

Section: Küçük Hücreli̇ Akci̇ğer Kanseri̇ (Khak) Evrelemeunclassified

Use Of Pet In Radiationtreatment Planning For Thoracic Malingnancies

Berberoğlu¹

2015

Toraks Cer Bult

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Evaluation of outcome prediction and disease extension by quantitative 2-deoxy-2-[18F] fluoro-d-glucose with positron emission tomography in patients with small cell lung cancer

Abstract: FDG-PET imaging is a valuable tool in the management of patients with SCLC for a more accurate staging. The use of quantitative PET parameters may have a role in prediction of stage and survival.

Cited by 51 publications

References 18 publications

Variability of Total Lesion Glycolysis by 18F-FDG-Positive Tissue Thresholding in Lung Cancer

Variability of Total Lesion Glycolysis by 18F-FDG-Positive Tissue Thresholding in Lung Cancer

Pretreatment PET/CT Standardized Uptake Values Play a Role in Predicting Response to Treatment and Survival in Patients with Small Cell Lung Cancer

Use Of Pet In Radiationtreatment Planning For Thoracic Malingnancies

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