Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections

Azari, Feredun; Kennedy, Gregory T.; Bernstein, Elizabeth; Delikatny, James; Lee, John Y.K.; Kucharczuk, John C.; Low, Phil; Singhal, Sunil

doi:10.1007/s11307-021-01618-9

Cited by 15 publications

(12 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The sensitivity and specificity were 58.3–100% and 20–42.9%, respectively. The positive and negative predictive values were 87.1–94.2% and 26.7–50%, respectively [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ]. All of these values apply to in situ results and will be higher when fluorescence assessment is performed ex vivo since TBRs of the lesions are higher when measured in back table pathology assessments.…”

Section: Resultsmentioning

confidence: 99%

“…A large retrospective cohort study showed that there was no significant difference between the TBR of malignant and benign lesions [ 78 ]. The sensitivity in patients with adenocarcinoma (84%) was higher than in patients with squamous cell carcinoma (58.3%) [ 73 , 76 ].…”

Section: Resultsmentioning

confidence: 99%

“…Histopathological examination showed that 56.3–100% of tumor margins were true positives [ 72 , 77 , 79 ]. Clinically significant events, which means that the surgical plan is changed by the results of fluorescence imaging, happened in 0–45% of patients [ 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

“…There was no significant correlation found between fluorescence signals and the SUVmax on PET/CT or with the size or location of the lesion in different lobes. However, there was a significant correlation between fluorescence signals and the depth of the lesion [ 72 , 75 , 76 , 78 ]. The deepest lesion found was located 20 mm below the surface of the lung, as observed on the preoperative CT scan.…”

Section: Resultsmentioning

confidence: 99%

“…Adverse events were described in four studies. In two of these studies, no adverse events were seen [ 72 , 78 ]. In the other two studies, 15–21.8% of the patients did have adverse events, most of which were complaints of nausea.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Neijenhuis

Muynck

Bijlstra

et al. 2022

Life

View full text Add to dashboard Cite

Lung cancer is the most common cancer type worldwide, with non-small cell lung cancer (NSCLC) being the most common subtype. Non-disseminated NSCLC is mainly treated with surgical resection. The intraoperative detection of lung cancer can be challenging, since small and deeply located pulmonary nodules can be invisible under white light. Due to the increasing use of minimally invasive surgical techniques, tactile information is often reduced. Therefore, several intraoperative imaging techniques have been tested to localize pulmonary nodules, of which near-infrared (NIR) fluorescence is an emerging modality. In this systematic review, the available literature on fluorescence imaging of lung cancers is presented, which shows that NIR fluorescence-guided lung surgery has the potential to identify the tumor during surgery, detect additional lesions and prevent tumor-positive resection margins.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Neijenhuis

Muynck

Bijlstra

et al. 2022

Life

View full text Add to dashboard Cite

show abstract

Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors

Abdelhafeez

Mothi

Pio

et al. 2023

Pediatric Blood & Cancer

View full text Add to dashboard Cite

BackgroundClearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can be challenging. Therefore, an intraoperative tool that localizes pulmonary metastases is needed to improve diagnostic and therapeutic resections. Indocyanine green (ICG) real‐time fluorescence imaging is used for this purpose in adult solid tumors, but its utility in pediatric solid tumors has not been determined.MethodsA single‐center, open‐label, nonrandomized, prospective clinical trial (NCT04084067) was conducted to assess the ability of ICG to localize pulmonary metastases of pediatric solid tumors. Patients with pulmonary lesions who required resection, either for therapeutic or diagnostic intent, were included. Patients received a 15‐minute intravenous infusion of ICG (1.5 mg/kg), and pulmonary metastasectomy was performed the following day. A near‐infrared spectroscopy iridium system was optimized to detect ICG, and all procedures were photo‐documented and recorded.ResultsICG‐guided pulmonary metastasectomies were performed in 12 patients (median age: 10.5 years). A total of 79 nodules were visualized, 13 of which were not detected by preoperative imaging. Histologic examination confirmed the following histologies: hepatoblastoma (n = 3), osteosarcoma (n = 2), and one each of rhabdomyosarcoma, Ewing sarcoma, inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, and papillary thyroid carcinoma. ICG guidance failed to localize pulmonary metastases in five (42%) patients who had inflammatory myofibroblastic tumor, atypical cartilaginous tumor, neuroblastoma, adrenocortical carcinoma, or papillary thyroid carcinoma.ConclusionsICG‐guided identification of pulmonary nodules is not feasible for all pediatric solid tumors. However, it may localize most metastatic hepatic tumors and high‐grade sarcomas in children.

show abstract

Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer

Azari

Kennedy

Chang

et al. 2022

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections

Cited by 15 publications

References 28 publications

Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Near-Infrared Fluorescence Tumor-Targeted Imaging in Lung Cancer: A Systematic Review

Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors

Presence of non-Newtonian fluid in invasive pulmonary mucinous adenocarcinomas impacts fluorescence during intraoperative molecular imaging of lung cancer

Contact Info

Product

Resources

About