Evaluation of osteopontin and CD44v6 expression in odontogenic cystic lesions by immunohistochemistry

Salehinejad, Jahanshah; Saghafi, Shadi; Sharifi, Nasibeh; Zare-Mahmoodabadi, Reza; Saghravanian, Nasrollah; Ghazi, Narges; Shakeri, Mohammad Taghi

doi:10.1016/j.prp.2012.04.005

Cited by 14 publications

(20 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies disclose the role of different adhesion molecules in the pathogenesis and aggressive behavior of odontogenic lesions ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

CD166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma

Andisheh-Tadbir¹,

Gorgizadeh²

2016

J Clin Exp Dent

View full text Add to dashboard Cite

BackgroundCD166 is a glycoprotein of an immunoglobulin super family of adhesion molecules that has been associated with aggressive characteristics and high recurrence rate of tumors. Different odontogenic lesions exhibit considerable histological variation and different clinical behavior. In an attempt to clarify the mechanisms underlying this different behavior, the present study investigates the immunohistochemical expression of CD166 in these lesions.Material and MethodsIn this study 69 formalin-fixed, paraffin embedded tissue blocks of odontogenic lesion consist of 15 unicystic ameloblastoma (UA), 17 solid ameloblastoma (SA), 18 keratocystic odontogenic tumors (KCOT), and 19 dentigerous cysts (DC) were reviewed by immunohistochemistry for CD166 staining.ResultsIn this study, CD166 immune staining was evident in all specimen groups except dentigerous cyst. In positive cases, protein localization was cytoplasmic and/or membranous. CD166 expression was seen in76.5% (13) of SA, 73.5% (11) of UA, and 66.7% (12) of KCOTs. Statistical analysis showed that CD166 expression levels were significantly higher in ameloblastoma (SA and UA) and KCOTs than dentigerous cyst (P <0.001), but there was no statistically significant difference between CD166 expression in the other groups (P>0.05).ConclusionsThis data demonstrates that overexpression of CD166 may have a role in the pathogenesis of ameloblastoma and KCOT. Key words:CD166, ameloblastoma, dentigerous cyst, odontogenic keratocyst.

show abstract

“…Previous studies disclose the role of different adhesion molecules in the pathogenesis and aggressive behavior of odontogenic lesions ( 19 , 20 ).…”

Section: Introductionmentioning

confidence: 99%

CD166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma

Andisheh-Tadbir¹,

Gorgizadeh²

2016

J Clin Exp Dent

View full text Add to dashboard Cite

show abstract

“…Among its multiple variant isoforms, CD44v6 is positively correlated with invasion and metastasis in many human malignancies . In the jaws, CD44v6 is implicated in the locally aggressive behavior of odontogenic tumors including ameloblastoma .…”

Section: Introductionmentioning

confidence: 99%

“…A crucial step here is weakening of cell–cell adhesion mechanisms (which involve E‐cadherin, β‐catenin, and CD44v6). Although the immunoprofiles of these proteins in ameloblastoma are well enumerated , it is unclear whether these expression patterns apply to the recurrent tumors as well. It is known that morphological, signaling, and genetic differences may exist between primary and recurrent tumors .…”

Section: Introductionmentioning

confidence: 99%

Podoplanin, E‐cadherin, β‐catenin, and CD44v6 in recurrent ameloblastoma: their distribution patterns and relevance

Siar

Ishak

2014

J Oral Pathology Medicine

View full text Add to dashboard Cite

show abstract

“…[ 35 ] It interacts with other GAGs (HA) and different proteins such as fibronectin, type I and IV collagens and osteopontin (OPN). [ 36 ] Due to its interactions with multiple molecules, CD44 regulates and participates in cellular processes such as adhesion (cell–cell and cell–ECM), angiogenesis, differentiation, migration, survival and proliferation. [ 35 ]…”

Section: Resultsmentioning

confidence: 99%

Proteoglycans as potential biomarkers in odontogenic tumors

Gómez-Herrera

Molina-Frechero

Damián-Matsumura

et al. 2018

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Evaluation of osteopontin and CD44v6 expression in odontogenic cystic lesions by immunohistochemistry

Cited by 14 publications

References 20 publications

CD166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma

CD166 expression in dentigerous cyst, keratocystic odontogenic tumor and ameloblastoma

Podoplanin, E‐cadherin, β‐catenin, and CD44v6 in recurrent ameloblastoma: their distribution patterns and relevance

Proteoglycans as potential biomarkers in odontogenic tumors

Contact Info

Product

Resources

About