Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Abstract

Objectives: The aim of this study was to evaluate the osteoblastic activity around delay‐loaded intraosseous dental implants using nuclear medicine imaging techniques. Material and methods: Seven totally edentulous patients (two females and five males, between 48 and 57 years of age) were included in the study. Two implants were inserted into mandibular canine regions and removable prostheses were produced after 3 months. Whole‐body bone scintigraphies with 20 mCi technetium 99m labelled methylene diphosphonate were taken from the patients before implant insertion, 3 months after implant placement just before the prostheses were made and 1 year after implant placement. Standardized count/pixel (SC/P) rates were calculated for each patient. Preimplantation SC/P values were compared with the 3‐ and 12‐month values. Three‐month values were compared with the 12‐month values as well. Results: SC/P rates in the third month were significantly higher (P<0.05) than preoperative values and the SC/P rates of the 12th month were significantly lower (P<0.05) than 3‐month values. The SC/P rates of the 12th month were relatively higher than first scintigraphies but the difference was insignificant (P>0.05). Conclusions: Within the limitations of this study, in which delayed loading was applied, we showed that osteoblastic activity persisted more in delay loaded implants than immediate and early loading. After 1 year, there was no cellular activity around two implants and this implied that two implants were sufficient for a total prosthesis. To cite this article: Kalayci A, Durmus E, Tastekin G, Isik K, Inan Ö. Evaluation of osteoblastic activity around dental implants by using bone scintigraphy. Clin. Oral Impl. Res. 21, 2010; 209–212. doi: 10.1111/j.1600‐0501.2009.01822.x

Osteosarcoma of the Maxilla: Mimicking Dental Pathology on Bone Scan

“…Her ne kadar osteosarkom gibi çene yerleşimli primer kemik tümörleri kemik sintigrafisinde yoğun artmış aktivite tutulumuna neden olsa da, mandibular osteomyelit, tüberküloz, hiperparatiroidi, brown tümör, cerrahi girişim gibi benign süreçler ile dental implantlar, periodontit, periodontal kist, diş çekimi ve apikal periodontal inflamasyon gibi dental patolojiler de, çene bölgesinde, artmış aktivite tutulumlarına neden olur (9)(10)(11). Özellikle dental implantlar, implantı takip eden ilk birkaç ay içinde kemik sintigrafisinde yoğun artmış aktivite tutulumuna neden olur ve bu artmış tutulum genelde bir yıl civarında normal düzeylere inse de bu süre uzayabilir (12,13). Bu vakada da maksiller yerleşimli osteosarkoma ait artmış aktivite tutulumu ilk bakışta bir dental patolojiden kaynaklandığı düşünülmüştü.…”

Revisión bibliográfica de Implantología Bucofacial del año 2010: Primera Parte

“…Otros estudios defienden que la carga inmediata o temprana de implantes que soportan sobredentaduras mandibulares en la zona intermentoniana, donde la calidad del hueso suele ser buena, no influyen en la salud del tejido periimplantario, la reabsorción marginal del hueso periimplantario o la estabilidad de los implantes (128,(131)(132)(133), aunque histológicamente se ha descrito que en implantes cargados tardíamente existe una mayor actividad osteoblástica a su alrededor que en los sometidos a cargas tempranas (134).…”

Nano‐sized Carrier Systems as New Materials for Nuclear Medicine

“…Hydroxybisphosphonates and their metal complexes are very quickly and strongly accumulated in bones after administration [75] and inhibit bone resorption, which is exploited in paliative treatment of bone metastases [75][76][77], therapy of osteoporosis [75,77] and of Paget disease [75]. Radiometal complexes of bisphosphonates, especially methylenediphosphonate complex with 99m Tc, are widely used in bone scintigraphy [78][79][80], since bisphosphonates accumulate more in places of bone with high remodelling rate where hydroxyapatite is more exposed to blood, i.e. in bone metastases and broken/damaged areas [78][79][80].…”

“…Radiometal complexes of bisphosphonates, especially methylenediphosphonate complex with 99m Tc, are widely used in bone scintigraphy [78][79][80], since bisphosphonates accumulate more in places of bone with high remodelling rate where hydroxyapatite is more exposed to blood, i.e. in bone metastases and broken/damaged areas [78][79][80]. This is why hydroxybisphosphonate moieties were also proposed for targeting of polymer carriers [81,82].…”