Evaluation of Osseous Metastasis in Bone Scintigraphy

Dávila, Diego F.; Antoniou, Alexander; Chaudhry, Muhammad

doi:10.1053/j.semnuclmed.2014.07.004

Cited by 64 publications

(36 citation statements)

References 19 publications

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“…Bone is the third most common site for metastatic disease (after lung and liver) and more prevalent in adult patients (>40 years of age) [2]. Notorious for causing severe pain, bone metastases are also the major reasons for pathologic fracture, life-threatening hypercalcemia, spinal cord compression, immobility and ultimate mortality in patients affiliated with advanced cancers in the breast, prostate, lung, kidney, thyroid, as well as hematologic malignancies like myeloma [3].…”

Section: Bone Metastasismentioning

confidence: 99%

New therapeutic targets for cancer bone metastasis

Krzeszinski

Wan

2015

Trends in Pharmacological Sciences

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Bone metastases are dejected consequences of many types of tumors including breast, prostate, lung, kidney and thyroid cancers. This complicated process begins with the successful tumor cell epithelial–mesenchymal transition, escape from the original site, and penetration into circulation. The homing of tumor cells to the bone depends on both tumor-intrinsic traits and various molecules supplied by the bone metastatic niche. The colonization and growth of cancer cells in the osseous environment, which awaken their dormancy to form micro- and macro-metastasis, involve an intricate interaction between the circulating tumor cells and local bone cells including osteoclasts, osteoblasts, adipocytes and macrophages. In this review, we discuss the most recent advances in the identification of new molecules and novel mechanisms during each step of bone metastasis that may serve as promising therapeutic targets.

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Section: Bone Metastasismentioning

confidence: 99%

New therapeutic targets for cancer bone metastasis

Krzeszinski

Wan

2015

Trends in Pharmacological Sciences

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“…Certain neoplasms demonstrate characteristic imaging findings, such as prostate cancer with sclerotic osseous metastases on CT and osteoblastic technetium-99m radiotracer uptake on bone scintigraphy. 7 However, diagnosis by imaging is often confounded by the variety of presentations and multiple non- neoplastic etiologies with similar findings. A tissue biopsy is often needed for pathological confirmation.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography–guided percutaneous biopsy for vertebral neoplasms: a department's experience and hybrid biopsy technique to improve yield

Garg

Kosmas

Josan

et al. 2016

FOC

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OBJECTIVE Recent articles have identified the poor diagnostic yield of percutaneous needle biopsy for vertebral osteomyelitis. The current study aimed to confirm the higher accuracy of CT-guided spinal biopsy for vertebral neoplasms and to identify which biopsy technique provides the highest yield. METHODS Over a 9-year period, the radiology department at University Hospitals Case Medical Center performed 222 CT-guided biopsies of vertebral lesions, of which clinicians indicated a concern for vertebral neoplasms in 122 patients. A retrospective chart review was performed to confirm the higher sensitivity of the percutaneous intervention for vertebral neoplasms. RESULTS A core sample was obtained for all 122 biopsies of concern (100.0%). Only 6 cases (4.9%) were reported as nondiagnostic per histological sampling, and 12 cases (9.8%) were negative for disease. The question of vertebral neoplastic involvement warrants follow-up, and the current study was able to determine the subsequent diagnosis of each lesion. Of the 122 total, 94 (77.0%) core samples provided true-positive results, and the sensitivity of core biopsy measured 87.9%. The technical approach did not demonstrate any significant difference in diagnostic yield. However, when the vertebral cortex was initially pierced with a coaxial bone biopsy system and subsequently a 14-gauge spring-loaded cutting biopsy needle was coaxially advanced into lytic lesions, 14 true positives were obtained with a corresponding sensitivity of 100.0%. CONCLUSIONS This study confirms the higher sensitivity of image-guided percutaneous needle biopsy for vertebral neoplasms. In addition, it demonstrates how the use of a novel cutting needle biopsy approach, performed coaxially through a core biopsy track, provides the highest yield.

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“…Los osteoblastos forman la matriz osteoide que posteriormente será mineralizada por los cristales de hidroxiapatita. El metilendifosfonato (99mTc-MDP) se une mediante quimioadsorción a los cristales de hidroxiapatita en función de dos situaciones: el flujo sanguíneo y la actividad osteoblástica 6,7 . Conforme la NCCN, el gammagrama óseo está indicado en pacientes con niveles de APE > 20 ng/ml, Gleason ≥ 8, T3, T4 o T2 si APE > 10 ng/ml, o si presentan síntomas 8 .…”

Section: Metilendifosfonatounclassified

Radiotrazadores empleados en medicina nuclear para el diagnóstico y seguimiento del cáncer de próstata

García-Pérez¹,

Medina-Ornelas²

2022

GAMO

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Resumen El cáncer de próstata (CP) es la causa más común de cáncer en hombres a nivel mundial. Actualmente, la imagen en el CP ha tomado una gran importancia para la estadificación, reestadificación, selección del tratamiento y evaluación de la recurrencia. La imagen molecular con tomografía por emisión de positrones (PET) ha permitido un enfoque personalizado para estos propósitos. Además de estas necesidades clínicas, existe una creciente visión y reto para las nuevas técnicas de imagen molecular, no sólo para detectar la enfermedad metastásica, sino también para proporcionar información importante acerca de la biología tumoral, el pronóstico y, uno de los retos más grandes de las técnicas de imagen no radioisotópicas, la detección de recurrencia en pacientes con niveles bajos de antígeno prostático específico (APE). (creativecommons.org/licenses/by-nc-nd/4.0/). ARTÍCULO DE REVISIÓNRadiotrazadores empleados en medicina nuclear para el diagnóstico y seguimiento del cáncer de próstata

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Evaluation of Osseous Metastasis in Bone Scintigraphy

Cited by 64 publications

References 19 publications

New therapeutic targets for cancer bone metastasis

New therapeutic targets for cancer bone metastasis

Computed tomography–guided percutaneous biopsy for vertebral neoplasms: a department's experience and hybrid biopsy technique to improve yield

Radiotrazadores empleados en medicina nuclear para el diagnóstico y seguimiento del cáncer de próstata

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