Evaluation of Oral Ginger Efficacy against Postoperative Nausea and Vomiting: A Randomized, Double - Blinded Clinical Trial

Abstract

Background:Postoperative nausea and vomiting is one of the most common side effects associated with surgical procedures.Objectives:The aim of this study was to determine the effect of ginger on intensity of nausea and vomiting after surgical procedures.Patients and Methods:This study was a randomized, double blinded, clinical trial. 160 eligible patients were randomly assigned into experimental or placebo groups. The experimental group received 4 capsules containing 250 mg ginger and placebo group received 4 placebo capsules 1 hour before surgery. The severity of nausea and vomiting was measured at 2, 4, 6 hours post operation using visual analogue scale and a structured questionnaire. The data were analyzed by independent t - test, Mann-Whitney U test, chi –square and GEE using SPSS 16 and STATA version 11.Results:Mean nausea score at 2 hours post operation was significantly lower in the experimental group (P= 0.04). Mean nausea score at 4 and 6 hours post operation was lower in the experimental group; however, there was no significant difference between the groups at any time post operation. The frequencies of nausea in the experimental group at 2 and 6 hours post operation were lower than that in the placebo group, however, at 2 hours post operation, it was borderline significant (P = 0.05) There was no significant differences between two group in the intensity of vomiting at any time.Conclusions:Use of ginger was effective at decreasing postoperative nausea. Ginger could be used as a safe antiemetic drug at post operation.

Is ginger beneficial for nausea and vomiting? An update of the literature

“…The identified clinical studies that have investigated postoperative nausea and vomiting and CINV, for example have generally reported statistically significant reductions in measures of nausea and vomiting; however, the magnitude of this reduction was generally small and so less likely to result in a substantial benefit to the patient [11,14,17]. The study conducted by Dabaghzadeh et al [16 & ] in contrast, demonstrated a considerable difference between the intervention and placebo group and if further studies report similar findings, this is likely to provide a clinically significant benefit to the patient.…”

“…Mandal et al [17] investigated the effect of ginger on 100 participants undergoing a range of surgeries in the ambulatory setting and reported significantly reduced severity of nausea and vomiting symptoms 4 and 6 hours postsurgery as well as significant reductions in the incidence of postoperative nausea and vomiting at multiple time points within the 18 hours postsurgery. Montazeri et al [11] also investigated ginger as a treatment for postoperative nausea and vomiting at 2, 4, and 6 hours postsurgery in patients undergoing diverse surgeries and reported a modest benefit in nausea reduction at 2 hours. As previous studies have been primarily in patients receiving gynaecological surgeries, these results add to the literature by demonstrating potential efficacy in a broader range of surgeries.…”

Ingwer: Gewürz und Arzneipflanze - wenig bekannte und unterschätzte therapeutische Eigenschaften

“…Ausschliesslich mit postoperativer Nausea und postoperativem Erbrechen befasste sich die Studie von Montazeri et al [32], die 2013 publiziert wurde. 160 randomisierte Patienten erhielten 1 h vor einem chirurgischen Eingriff 100 mg Ingwer oder Placebo.…”

Multi-Target-Wirkmechanismen des pflanzlichen Vielstoffgemischs Padma Lax bei Obstipation

“…Diese Hemmung korreliert mit den Ergebnissen der bereits oben genannten Studie zur Motilität mit Padma Lax [20]. Ferner ist Ingwer für seine antiemetischen, karminativen und spasmolytischen Eigenschaften bekannt [26][27][28][29].…”