Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

Volgger, Veronika; Stepp, Herbert; Ihrler, Stephan; Kraft, Marcel; Leunig, Andreas; Patel, Parag M.; Susarla, Malavika; Jackson, K.; Betz, Christian

doi:10.1002/hed.23189

Cited by 34 publications

(36 citation statements)

References 28 publications

(38 reference statements)

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“…Classification of autofluorescence endoscopy images by an experienced head and neck surgeon has a better sensitivity, specificity, and accuracy than white light endoscopy of 91% versus 73%, 84% versus 79%, and 88% versus 77%, respectively . For optical coherence tomography, a sensitivity and specificity of 77.8% to 100% and 70.3% to 75.8%, respectively, is reported to differentiate an invasive from a noninvasive lesion in the upper aerodigestive tract . Using high‐resolution microendoscopy to image neoplastic versus nonneoplastic oral cancer, subjective image interpretation yielded sensitivity and specificity of 85% to 90% and 80% to 85%, respectively, whereas an objective classification algorithm achieved sensitivity and specificity of 81% and 77%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer

et al. 2015

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“…UADT), flexible OCT probes provide resolutions on the order of 10 mm and penetration depths of 2 mm into soft tissues. The predominant diagnostic feature is the recognition of the integrity of the basement membrane, identifying early invasive lesions by the loss of contrast between the epithelial and connective tissue layers with a high sensitivity [12][13][14].…”

Section: Sectional Imaging Methodsmentioning

confidence: 99%

Confocal laser endomicroscopy in head and neck cancer

Volgger¹,

Conderman

Betz³

2013

Current Opinion in Otolaryngology & Head and Neck Surgery

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Purpose of reviewConfocal laser endomicroscopy (CLE) is a novel, noninvasive technique used to obtain microanatomical images of the inner lining of hollow organs. It has been used in a variety of clinical specialties to aid in the diagnosis and treatment planning of inflammatory and neoplastic processes. Our intent is to provide an up-to-date review of the literature in the setting of head and neck diseases as well as describing our own initial results and areas of future research. Recent findingsWith increasing experience using CLE in the upper aerodigestive tract (UADT), evidence is mounting that this method can be a useful adjunct to standard endoscopy and other diagnostic techniques. Recent publications have shown that by using CLE, microanatomical structures of healthy and diseased mucosa can easily be identified, allowing for a differentiation of dysplastic/neoplastic and benign mucosal lesions. Standardized diagnostic protocols as well as clinically relevant classification systems for the UADT have not yet been described. SummaryCLE is an imaging modality that allows real-time visualization of mucosal cellular architecture and other histologic characteristics. First reports on its use in the UADT have yielded promising results, but the true value of this method is yet to be determined.

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“…OCT has been applied in intraoperative margin detection in cutaneous, vulvar, breast, and gastro-intestinal malignancy [47][48][49][50][51] . OCT has been examined in several diagnostic/detection applications in the head and neck such as larynx, oral, and esophageal cancer however studies examining the ability of OCT to determine the accuracy intra-operative margins are less common [20,21,49,[52][53][54][55][56][57] . Hamdoon et al, examined the use of OCT for intraoperative margin evaluation in twenty-eight T1-T2 N0M0 oral cavity squamous cell carcinoma patients.…”

Section: Optical Coherence Tomography (Oct)mentioning

confidence: 99%

How Close Are We to Real Time Optical Margin Control in Head and Neck Oncologic Surgery?

Miles

2016

Cancer Cell Microenviron

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The quest for negative margins during head and neck oncologic surgery continues to challenge surgeons worldwide. Current technological advances offer significant promise to advance the field and improve operative margin detection. This review focuses on current optical technology, which has been evaluated for intraoperative margin control in head and neck oncologic surgery. Many of the current systems have technical limitations and there is no current standard technology being applied in the field of head and neck oncology to enhance intraoperative margin control. Surgeons continue to rely on intraoperative frozen section analysis, however many optical systems have shown high rates of sensitivity and specificity when discriminating benign from malignant tissue. These technologies shows significant promise for intraoperative margin control and may be enhanced by targeted molecular imaging, or spectral analysis, in the future. Translational trials are rare and are the key to the path of independence from frozen section analysis.

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Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

Abstract: OCT complements visual inspection for differentiating UADT-lesions.

Cited by 34 publications

References 28 publications

Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer

Automated analysis of confocal laser endomicroscopy images to detect head and neck cancer

Confocal laser endomicroscopy in head and neck cancer

How Close Are We to Real Time Optical Margin Control in Head and Neck Oncologic Surgery?

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