Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Meriç, Ayşenur; Doğan, Remzi; Veyseller, Bayram; Su, Özlem; Özüçer, Berke; Tuğrul, Selahattin; Özturan, Orhan

doi:10.2500/ajra.2014.28.4023

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…In the present study 50% of patients with postinfectious olfactory loss showed ANAs. These results suggest that postinfectious smell loss might be related to immune mediated processes as reduced olfactory function has been already shown in several autoimmune meditaed diseases such as multiple sclerosis (27) , pemphigus vulgaris (10) , psoriasis vulgaris (11) and Sjögren syndrome (12) .…”

Section: Discussionsupporting

confidence: 59%

“…In several autoimmune diseases (8) decreased olfactory function has been shown, e.g. systemic lupus erythematosus (9) , pemphigus vulgaris (10) , psoriasis vulgaris (11) , Sjögren syndrome (12) and Wegener's disease (13,14) . In addition, reduced olfactory function has been shown in several other diseases, which are discussed to be mediated by autoimmune processes, e.g.…”

Section: Neurological Disorders and Autoimmune Processes Have Beenmentioning

confidence: 99%

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Antinuclear antibodies in postinfectious smell loss - a pilot study

Walliczek-Dworschak¹,

Zimmermann²,

Poletti³

et al. 2019

RHINOL

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Background: Numerous diseases are mediated by autoimmune mechanisms some of which have been shown to be associated with reduced olfactory function, e.g. systemic lupus erythematosus, Sjögren syndrome, psoriasis vulgaris. Postinfectious smell loss is a frequent cause of olfactory dysfunction. However, its nature is not fully understood, but connections to immune mediated processes might be possible. The primary aim of the present study was therefore to investigate the possible relation of postinfectious smell loss with autoimmune processes. Methods: Fifty-two patients (35 female, 17 male; mean age 57 years ± 12 years) with postinfectious smell loss and 56 controls (21 female, 35 male; mean age 58 years ± 13 years), with olfactory dysfunction of other causes (sinunasal, posttraumatic or idiopathic)were included in the present study. The patients' olfactory function was measured using the extended test battery of the "Sniffin' Sticks". Furthermore venous blood samples were taken and analyzed for antinuclear autoantibodies. Results:Patients showed anti-nuclear antibodies (ANA) significantly more frequently compared to controls, although ANAs were typically only present at cut off levels of 1:100. In addition, there was a significant association between the presence of ANAs and odor thresholds. Conclusions:Results from this study indicate that postinfectious olfactory dysfunction may be associated with autoimmune processes, as they show significantly more ANAs -although not at a clincially significant level -compared to patients with olfactory deficits of other origin.

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Section: Discussionsupporting

confidence: 59%

Section: Neurological Disorders and Autoimmune Processes Have Beenmentioning

confidence: 99%

Antinuclear antibodies in postinfectious smell loss - a pilot study

Walliczek-Dworschak¹,

Zimmermann²,

Poletti³

et al. 2019

RHINOL

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“…Regarding the response to treatment of NT involvement in PV, several studies have confirmed that systemic treatment is highly effective . Recovery of mucosal lesions is practically complete although recently, some rare cases of secondary epiglottis synechiae, or olfactory dysfunction have been reported . Secondary infection on NT mucosa might play a role in secondary and local fibrosis.…”

Section: Nt Involvement In Pvmentioning

confidence: 99%

“…2,3,[8][9][10][11][12] Recovery of mucosal lesions is practically complete although recently, some rare cases of secondary epiglottis synechiae, 18 or olfactory dysfunction have been reported. 19 Secondary infection on NT mucosa might play a role in secondary and local fibrosis. As a positive correlation has been detected between the duration of PV and the severity of NT involvement, 11 delay in beginning treatment may also lead to fibrous bands on NT mucosas.…”

Section: Nt Involvement In Pvmentioning

confidence: 99%

Exploring beyond the oral mucosa in patients affected with autoimmune blistering diseases: the importance of endoscopic procedures

España

Fernández

2016

Acad Dermatol Venereol

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Autoimmune blistering diseases (AIBD) comprise several entities characterized by the presence of autoantibodies targeted against structural proteins either in desmosomes or in the dermoepidermal junction of polystratified squamous epithelium. Patients develop blisters, erosions in cutaneous surfaces or mucosas. Diagnosis is based on the characteristic mucocutaneous lesions, the typical findings on histological studies and direct immunofluorescence assays, and the presence of specific autoantibodies against the epidermal antigens. It may not be possible for dermatologists to appropriately explore the nose and throat (NT). Thus, a clinical exploration by endoscopic procedures of NT may be a useful tool during the conventional dermatological exam. The aims of this review are to draw attention to the most frequent NT manifestations in AIBD patients, and underline the utility of endoscopic procedures to achieve a more successful and rationale management of patients. Additionally, we will provide brief information related to the anatomical structures and type of epithelium in NT areas which may explain the extent and type of NT involvement in AIBD. Endoscopic exploration in AIBD patients is important for several reasons. Firstly, it will allow the real NT mucosal involvement in each patient to be determined, thus making a differential diagnosis during the endoscopic exam possible, based on the localization of mucosal lesions. Secondary mucosal morbidity can also be ruled out. Secondly, the clinical response to treatment may be established, especially in NT mucosa, as these are anatomical areas subjected to important local traumas, and physiological functions such as breathing, swallowing, speech production and phonation may be damaged. Therefore, a multidisciplinary management in AIBD is mandatory by both dermatologists and otorhinolaryngologists, adding the clinical exploration by endoscopic procedures of NT to the conventional dermatological exam in all AIBD patients, irrespective of whether they exhibit associated symptoms.

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“…Meric et al 15 describe the relationship between pemphigus vulgaris and nasal inflammatory disease, demonstrating that these patients are more likely to exhibit nasal lesions and dysfunction of both odor threshold and identification. These findings underscore roles for nasal examination and olfactory evaluation in patients with this autoimmune disease.…”

mentioning

confidence: 99%

Editorial: Insights into Disease Pathogenesis and Novel Therapeutics

Ramakrishnan¹

2014

Am J Rhinol�Allergy

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As we strive to advance our understanding and management of sinonasal disorders, the March issue of American Journal of Rhinology and Allergy continues to offer useful information to clinicians and researchers, with an eye towards the future. In general, most patients with sinonasal disorders do fairly well utilizing current practice paradigms. However, as practitioners, it is clear to us that there are populations of allergy and sinus sufferers who do not respond to our current treatments, and unfortunately do not spontaneously improve simply with the passage of time. It seems that those are the very patients that frequent our offices the most, and those are the ones we most often ponder.

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Evaluation of Olfaction in Patients with Pemphigus Vulgaris

Abstract: PV causes olfactory dysfunction leading to eventual hyposmia that decreases quality of life. We suggest that olfactory testing be included in PV evaluation for the diagnosis and treatment of hyposmia, when necessary.

Cited by 7 publications

References 21 publications

Antinuclear antibodies in postinfectious smell loss - a pilot study

Antinuclear antibodies in postinfectious smell loss - a pilot study

Exploring beyond the oral mucosa in patients affected with autoimmune blistering diseases: the importance of endoscopic procedures

Editorial: Insights into Disease Pathogenesis and Novel Therapeutics

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