Evaluation of ocular pulse amplitude and choroidal thickness in diabetic macular edema

Abstract

Purpose The aim of this study is to evaluate the ocular pulse amplitude (OPA) and choroidal thickness (CT) measurements in patients with diabetic macular edema (DME) and healthy subjects. Methods A total of 34 patients (12 male and 22 female) who had type 2 diabetes mellitus with DME and 34 sex-matched healthy subjects (13 male and 21 female) were included in this prospective study. The intraocular pressure (IOP) and OPA were measured with Dynamic contour tonometer (Pascal DCT, Switzerland). The subfoveal CT was measured using the Cirrus HD-OCT (Carl Zeiss Meditec). The CT at 1500 μm and 3000 μm nasal and temporal to the central fovea was also measured. Results The mean IOP values were 18.4 ± 3.5 and 17.1 ± 2.1 mm Hg in DME patients and healthy controls, respectively (P = 0.091). The mean OPA values in patients with DME (2.58 ± 0.96) and controls (3.52 ± 1.03) were statistically different (Po0.001). The mean subfoveal CT value was 273.5 ± 30.2 μm in the eyes with DME and 321.4 ± 36.5 μm in the control group (Po 0.001). In both groups, linear regression analysis showed no significant association between OPA and CT measurements. The IOP showed a significantly positive correlation with OPA in both DME (P = 0.002, r = 0.526) and controls (P = 0.004, r = 0.483). Conclusions The current study suggests that both pulsatile choroidal blood flow and CT are decreased in patients with DME.

Choroidal Changes in Diabetic Patients With Different Stages of Diabetic Retinopathy

“…In Totan et al, mean OPA values in patients with DME were statistically decreased compared with controls (P<0.001). Mean SFCT, nasal and temporal CT values were significantly decreased in DME eyes compared to controls (P<0.001) [23].…”

“…contains some general information about the studies reviewed in this article. Endo et al,Wang and Tao, Gupta et al,Rewbury et al, Ohara et al, Tan et al, Hua et al, Kim et al, Sudhalkar et al, Totan et al., Gerendas et al, Lee et al, Adhi et al, Regatieri et al, and Gołębiewska et al evaluated CT measurements and some of these studies also evaluated CVI in diabetic patients with and without DR as described inTable 2[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. Kim et al only investigated for CVI in these patients[29].…”

Correlation of Ocular and Systemic Factors with the Presence of Serous Retinal Detachment in Diabetic Macular Edema

“…In a recent study, 17 impairment of the choroidal blood flow was reported in patients with DME. The decreased choroidal blood flow may cause tissue hypoxia and RPE function impairment that result in the development of DME.…”

Evaluation of Choroidal Thickness in Diabetic Macular Edema Using Spectral - Domain Optical Coherence Tomography Enhanced Depth Imaging Mode

“…The reduction in the total choroidal thickness in eyes with NPDR and DME is consistent with a previous study by Regatieri et al [15] on choroidal thickness in patients with diabetic retinopathy. Also, Totan et al [4] reported that the CH-T was significantly decreased in DME treatment-naive patients.…”

“…Diabetic macular edema (DME) is a leading cause of blindness in patients with diabetic retinopathy worldwide. Although alterations in retinal vasculature resulting in compromise of the blood-retinal barrier have been demonstrated to have a critical role in the pathophysiology of the disease, changes in the choroidal vasculature may also have a contributing role [4] . The choroidal vasculature may play a potential role in modulating disease severity by affecting the hydrostatic or osmotic pressures that determine the absorption rate of intraretinal fluid [5] .…”