Evaluation of ocular blood flow over time in a treated retinal arterial macroaneurysm using laser speckle flowgraphy

Abstract

Purpose To report the changes over time in ocular blood flow quantified by laser speckle flowgraphy (LSFG) in a treated large retinal arterial macroaneurysm (RAM). Observations A 72-year old female presented with sudden decreased vision in the left eye. Fundus examination revealed a RAM and vitreous hemorrhage (VH), which worsened over one month. A vitrectomy was performed to remove the VH, with 20% sulfur hexafluoride injected into the vitreous cavity. The VH recurred two weeks later and the RAM was found to have enlarged from one-quarter disc diameter (DD) to three DDs during a second vitrectomy. The RAM subsequently shrunk spontaneously to one DD without recurrent VH during the following 2 weeks. Beginning 4 weeks after the second vitrectomy we performed serial LSFG examinations of the RAM and found that the mean blur rate (MBR) of the RAM and retinal flow volume (RFV) in both the feeding arteriole and draining venule decreased as the RAM continued to involute. Conclusions and importance MBR and arteriolar and venular RFV measured by LSFG decreased with RAM involution. Longitudinal followup of blood flow by LSFG may be useful for noninvasive evaluation of the stability of RAMs.

Non-Invasive Evaluation of Retinal Vascular Alterations in a Mouse Model of Optic Neuritis Using Laser Speckle Flowgraphy and Optical Coherence Tomography Angiography

“…In addition to the use of OCTA for the non-invasive monitoring and quantification of MS-induced alterations in retinal vascular features, laser speckle flowgraphy (LSFG) has emerged as a valuable non-invasive tool to monitor changes in retinal blood flow under various pathological conditions [13][14][15][16][17][18]. By utilizing the laser speckle phenomenon, LSFG enables the quantitative estimation of blood flow in ocular tissues, including the retina.…”

A case of acute syphilitic posterior placoid chorioretinitis showing improved choroidal blood flow after treatment

“…Laser speckle flowgraphy (LSFG) is a technique involving non-invasive quantification of the relative blood flow changes in tissues and is used to investigate the changes in ocular blood flow in various ocular conditions. 2 , 3 In LSFG, the mean blur rate (MBR) is calculated from the moving erythrocytes illuminated by an 830-nm wavelength diode laser beam. MBR is expressed in arbitrary units (AU) and is considered an indicator of the relative erythrocyte velocity.…”

Age-related changes of ocular blood flow detecting by laser speckle flowgraphy

“…Неоднородная поверхность глазного дна освещается когерентным источником излучениялазером, а отраженное излучение, возвращаясь в оптическую систему, дает видимость последовательной картины рассеяния (т. е. картины спеклов), которая захватывается в виде изображения высокочувствительной CCD-камерой. Полученные сигналы обрабатываются компьютером для вывода на экран изображений глазного дна и двумерной карты кровотока, на которой визуализируется распределение скорости движения форменных элементов крови [10][11][12][13][14][15].…”

“…МBR является мерой относительной скорости кровотока и выражается в относительных единицах. Специализированное программное обеспечение LSFG Analyzer вычисляет MBR на основе интенсивности спекл-рисунка для каждой конкретной точки в конкретный момент [10][11][12][13][14]19].…”

“…Помимо интегрального показателя МВR можно отдельно вычислить MBR для крупных сосудов (MBR of Vascular area, MV) и микроциркуляторного русла (MBR of Tissue area, МТ) исследуемой области [10][11][12][13][14][15][16][17][18][19][20][21].…”