Evaluation of Nutritional Value and Antioxidative Properties of The Medicinal Plant Gynura procumbens Extract

Puangpronpitag, D.; Chaichanadee, S.; Naowaratwattana, Wanlaya; Sittiwet, Chaiyasit; Thammasarn, K.; Luerang, A.; Kaewseejan, Niwat

doi:10.3923/ajps.2010.146.151

Cited by 31 publications

(14 citation statements)

References 25 publications

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“…Based on the reported data, G. procumbens was found to display substantial antioxidant activity (Rosidah et al, 2008). Since lipid peroxidation is a common result of oxidative stress, the antioxidative effect of G. procumbens was revealed when it inhibited lipid peroxidation with the median effective concentration of 2.75 mg/mL (Luerang et al, 2010; Kumar and Pandey, 2013). In addition, the administration of methanol extract prior to oxidative stress induction was able to reverse the elevation of plasma lipid peroxidation in tested animals (Akowuah et al, 2012).…”

Section: Biological Activitiesmentioning

confidence: 99%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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Gynura procumbens (Lour.) Merr. (Family Asteraceae) is a medicinal plant commonly found in tropical Asia countries such as China, Thailand, Indonesia, Malaysia, and Vietnam. Traditionally, it is widely used in many different countries for the treatment of a wide variety of health ailments such as kidney discomfort, rheumatism, diabetes mellitus, constipation, and hypertension. Based on the traditional uses of G. procumbens, it seems to possess high therapeutic potential for treatment of various diseases making it a target for pharmacological studies aiming to validate and provide scientific evidence for the traditional claims of its efficacy. Although there has been considerable progress in the research on G. procumbens, to date there is no review paper gathering the reported biological activities of G. procumbens. Hence, this review aims to provide an overview of the biological activities of G. procumbens based on reported in vitro and in vivo studies. In brief, G. procumbens has been reported to exhibit antihypertensive, cardioprotective, antihyperglycemic, fertility enhancement, anticancer, antimicrobial, antioxidant, organ protective, and antiinflammatory activity. The commercial applications of G. procumbens have also been summarized in this paper based on existing patents. The data compiled illustrate that G. procumbens is a potential natural source of compounds with various pharmacological actions which can be utilized for the development of novel therapeutic agents.

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Section: Biological Activitiesmentioning

confidence: 99%

Gynura procumbens: An Overview of the Biological Activities

et al. 2016

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“…Antihypertensive properties have been reported in water and methanol extracts of Gynura procumbens (Puang‐Pronpitag et al . ). Pinto et al .…”

Section: Resultsmentioning

confidence: 97%

Optimization Extraction Conditions for Phenolic Compounds, Antioxidant and Inhibitory Activities of Angiotensin I-Converting Enzyme (ACE), α-Glucosidase and α-Amylase fromMentha Spicata L

Alu’datt

Rababah

Alhamad

et al. 2015

Journal of Food Biochemistry

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Ideal extraction conditions were estimated based on the maximum phenolic content, antioxidant activity and inhibitory activity of angiotensin-converting enzyme (ACE), α-glucosidase and α-amylase enzymes from Mentha spicata L. The optimum extraction conditions for phenolic compounds with maximum ACE inhibitory activity occurred in a mixture of acetone and water (1:1) at 40C for 6 h. The optimal extraction conditions for phenolic compounds with maximum α-amylase and α-glucosidase inhibitory activity were obtained in a mixture of methanol, acetone and water extraction (1:1:1) and in a mixture of methanol and distilled water (1:1) at 50C for 8 h. The major free phenolic compound extracted with the various extraction solvents, times and temperatures was rutin. The predominant bound phenolic compounds were caffeic acid and chlorogenic acid, which did not exist as free phenolic compounds. PRACTICAL APPLICATIONSThis study suggested the optimum extraction conditions of phenolic compounds with maximum capacity of antioxidant, antihypertensive and antidiabetic properties recommended to be used in food industry as pharmaceutical and nutraceutical herbal extract.

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“…The Meth extract with higher phenol contents has lower IC 50 values and hence exhibited higher scavenging activity. It is not surprising to us that the Meth extract contained more flavonoids than the aqueous Eth extract because literature reports that relative to aqueous Eth, methanol extraction has a much elevated yield of extraction of total phenolics and total flavonoids (Dhawan & Gupta, 2017;Puangpronpitag et al, 2010), and these dissolved chemicals could therefore work in synergy or separately to exhibit interesting posttreatment pharmacological effects including effects on steroidogenesis and spermatogenesis as well as antioxidant effect on the testis. This is therefore the first evidence to show that Meth extract of A. djalonensis root could improve testicular function many weeks after withdrawal of treatment.…”

Section: Discussionmentioning

confidence: 99%

Effects ofAnthocleista djalonensisroot extracts on reproductive hormones and testicular marker enzymes in adult male Wistar rats

Ezirim

Uwakwe

2019

Andrologia

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| INTRODUC TI ONMale fertility is controlled by a complex assortment of pituitarygonadal hormones and steroidogenic enzymes, and each of these enzymes works synergistically to maintain the proper function of the testis. The endocrine regulation of spermatogenesis is complex and consists of response mechanism involving hormones from hypothalamus, anterior pituitary gland and the reproductive organ (Wahab, Mokhtar, Halim, & Das, 2010). The gonadotropin-releasing hormone (GnRH), which is synthesised and discharged from the hypothalamus, binds to the receptor of the anterior pituitary, and in response to this stimulatory action, follicle-stimulating hormone (FSH) and luteinising hormone are secreted and released. The effect of luteinising hormone on the Leydig cells stimulates the production Abstract This study evaluated the effect of methanol and aqueous ethanol root extracts (200 mg/kg body weight) of Anthocleista djalonensis on sex hormone concentrations and testicular marker enzymes of adult rats after 60 days of administration followed by 60 days of treatment withdrawal. The results showed no significant changes in testosterone and follicle-stimulating hormone (FSH) levels during the 60 days of extract treatment. Interestingly, 60 days after treatment withdrawal, there was an increase in intratesticular and serum testosterone and serum FSH in the methanol but not aqueous ethanol extract post-treatment groups. Intratesticular 3β-hydroxysteroid dehydrogenase (3β-HSD) activity remained unaffected while that of 17β-HSD increased slightly during treatment of both extracts and the increase reached a statistical significance level (p < .05) during post-treatment. Gamma-glutamyltranspeptidase activity in the testis of the methanol but not aqueous ethanol extract-treated animals remained high during post-treatment compared to initial treatment values.Phytochemical analysis of the plant extracts showed that phenol and flavonoid constituents were higher in the methanol than the aqueous ethanol extract and has higher antioxidant activity. Altogether, post-treatment effect of the extract on the testis was more effective than treatment-related effect and the methanol extract appears to have better and consistent effects on the investigated parameters probably due to higher antioxidant activity conferred to it by its phenolic and flavonoid contents. K E Y W O R D SAnthocleista djalonensis, enzymes, hormones, post-treatment, testis How to cite this article: Ezirim CY, Abarikwu SO, Uwakwe AA.Effects of Anthocleista djalonensis root extracts on reproductive hormones and testicular marker enzymes in adult male Wistar rats. Andrologia. 2019;51:e13442. https ://doi.

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Evaluation of Nutritional Value and Antioxidative Properties of The Medicinal Plant Gynura procumbens Extract

Cited by 31 publications

References 25 publications

Gynura procumbens: An Overview of the Biological Activities

Gynura procumbens: An Overview of the Biological Activities

Optimization Extraction Conditions for Phenolic Compounds, Antioxidant and Inhibitory Activities of Angiotensin I-Converting Enzyme (ACE), α-Glucosidase and α-Amylase fromMentha Spicata L

Effects ofAnthocleista djalonensisroot extracts on reproductive hormones and testicular marker enzymes in adult male Wistar rats

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