Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women

Barbosa, Patricia R.; Stabler, Sally P.; Trentin, R.; Carvalho, Felipe R.; Luchessi, André Ducati; Hirata, Rosário Dominguez Crespo; Hirata, Mario H.; Allen, Robert H.; Guerra-Shinohara, Elvira María

doi:10.1016/j.cca.2007.10.023

Cited by 18 publications

(15 citation statements)

References 42 publications

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“…Individuals with the TT genotype have increased dietary folate requirements because they have lower RBC folate levels compared with those without this genetic variant, and the increase in tHcy is found mostly in patients with folate deficiency. However, in our study, mean RBC folate level and mean plasma concentration of Hcy did not vary significantly by genotype, and no correlation between folate intake and circulating levels stratified by genotype were found, also considering pregnancy and smoking status, confirming previous results reported in the general population [30], in women of childbearing age [31] and in folic acid-supplemented pregnant women [8]. Nevertheless, our results should be interpreted with caution due to the small number of women studied.…”

Section: Discussionsupporting

confidence: 81%

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

et al. 2013

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Background/Aims: An important public health issue is monitoring folate inadequacy in women of childbearing potential. The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Methods: A total of 204 women were enrolled in a cross-sectional study. Folate intake was assessed by a food frequency questionnaire, and RBC folate, tHcy and MTHFR C677T genotype were determined. Results: About half of the women had a decreased RBC folate level (<305 nmol/l) and all were <906 nmol/l, even though 51% of the subjects reported use of supplements. Overall 91.5% had a high Hcy concentration. Notably, younger women, and those with a low level of education, were shown to be at higher risk of inadequate RBC folate levels. Additionally, younger women were also at higher risk of carrying the TT genotype, particularly unfavorable in the setting of a low folate status. Conclusions: Our study revealed significant folate deficiency in our Mediterranean population and higher than ideal Hcy concentrations, thus emphasizing that in these groups an improvement in the folate status is needed via a food-based approach or supplement. Consequently, public health policy strategies aiming at improved supplementation are required.

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Section: Discussionsupporting

confidence: 81%

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

et al. 2013

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“…In addition to the MTHFR gene, other genetic polymorphisms involved in the folate pathway seem to modulate the maternal risk for bearing a child with DS (Bosco et al, 2003;J.M. Biselli et al, 2008a;Meguid et al, 2008;Pozzi et al, 2009;Sadiq et al, 2011;Scala et al, 2006;Wang et al, 2008) as well as the concentrations of metabolites involved in the folate pathway (Ananth et al 2007;Barbosa et al, 2008;Cheng et al, 2010;Devos et al, 2008). The MTR 2756 A→G polymorphism has been associated with increased maternal risk for DS in the presence of AG or GG genotypes, as well as when combined with polymorphisms MTRR 66 A→G (MTR 2756AG/MTRR 66AG) (Bosco et al, 2003) and MTHFR 677 C→T (MTHFR 677TT/MTR 2756AA).…”

Section: Folate Metabolism Genomic Stability and Maternal Risk For mentioning

confidence: 99%

Abnormal Folate Metabolism and Maternal Risk for Down Syndrome

Pavarino¹,

Zampieri²,

Biselli³

et al. 2011

Genetics and Etiology of Down Syndrome

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“…The prevalence of folate and cobalamin deficiency during pregnancy is relatively high in some countries of Sub-Saharan Africa, northern Europe and in Brazil [5][6][7][8]. Disorders in the maternalfetal homocysteine (Hcy) metabolism due to folate and/or cobalamin deficiencies are related to a wide array of pathological conditions, such as recurrent miscarriages, placental abruption, preeclampsia, neural tube closure defects and intrauterine growth retardation [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Maternal Vitamin B Deficiency and Epigenetic Changes of Genes Involved in the Alzheimer’ s Disease Pathogenesis

Silva¹,

Fernandes²,

Agamme³

et al. 2017

Biol Med (Aligarh)

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Alzheimer's disease (AD) is characterized by progressive neurodegenerative impairment of the central nervous system and is the most prevalent form of dementia. Considering the influence of maternal nutrition on fetal programming, which consequences usually come later in life, we investigated whether maternal vitamin B deficiency during early development alters the offspring expression of genes related to AD etiopathogenesis. Mice dams were submitted to experimental diet one month before and during pregnancy or pregnancy/lactation and, after birth, their offspring were distributed into three groups: control "CT", deficient pregnancy "DP" and deficient pregnancy and lactation "DPL". At postnatal day (PND) 0, a significant decrease of App in females (p=0.007) and App and Bace1 in males (p=0.030 and p=0.040, respectively) was observed when compared to CT group. At PND 28, DPL female presented an increase of App, Bace1 and Ps1 gene expression when compared to CT (p=0.003, p=0.003 and p=0.002, respectively) and DP groups (p=0.017, p=0.005 and p=0.002, respectively). In males at PND 28, a decrease of App and Ps1 was observed in both DP (p=0.012; p=0.001) and DPL (p=0.001; p=0.04) when compared to CT group. No differences were observed in females and males at PND 210. Regarding APP, BACE1 and PS1 protein expression and global DNA methylation pattern, no difference was observed throughout development in female or male offspring. Regarding behavioral evaluations, no changes were observed in the object recognition task, but the DPL males presented lower locomotor activity when compared to DP (p=0.028) and CT (p=0.003) groups. In conclusion, the early exposition to vitamin B deficiency alters the expression of genes related to AD.

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Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women

Cited by 18 publications

References 42 publications

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

Dietary Folate Intake and Blood Biomarkers Reveal High-Risk Groups in a Mediterranean Population of Healthy Women of Childbearing Potential

Abnormal Folate Metabolism and Maternal Risk for Down Syndrome

Maternal Vitamin B Deficiency and Epigenetic Changes of Genes Involved in the Alzheimer’ s Disease Pathogenesis

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