Cognitive enhancement (CE) is defined as the improvement or extension of core capacities of cognition (eg, memory, attention, concentration and intelligence) of healthy individuals without any medical indications. 1 This situation also described as neuroenhancement, cosmetic neurology or brain doping. 2 Pharmacological cognitive enhancement (PCE), which is a type of CE, can be defined as the use of various drugs or other psychoactive substances. 3,4 Because PCE is often used to increase academic success, these drugs are also called study drugs or smart drugs. Prescribed psychostimulants (PS), such as methylphenidate and modafinil, are the most frequently consumed smart drugs to increase concentration and reduce sleep. These drugs prevent the reuptake of neurotransmitters that play an important role in cognition and pleasure, such as dopamine and norepinephrine, in the brain. 4,5 Effective management of psychoactive substances in healthy people has been an important public health problem due to the easier accessibility and lifestyle use. 6 There are several risks associated with using psychoactive drugs. Psychostimulants are one of the most frequently abused classes of pharmaceutical drugs. 7 They can lead to an increased tolerance for the drugs and create