Evaluation of Noninvasive Versus Invasive Techniques for the Diagnosis of Helicobacter pylori Infection

El-Din, Hanaa M Alam; Hashem, Abdel Gawad M.; Ragab, Yasser; Hussein, Iman; Mohamed, Dalia B.; Mohamed, El-Chaimaa B.

doi:10.1097/pai.0b013e31826e4e61

Cited by 7 publications

(3 citation statements)

References 28 publications

(28 reference statements)

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“…They concluded that IgG antibody to H. pylori might be useful in epidemiologic studies involving large numbers of participants. In agreement with the present study, Alam El-Din et al, [ 21 ] concluded that diagnosis of H. pylori infection by noninvasive methods, including the serum antibody test, revealed a sensitivity and positive predictive value of 88.9% and 94.2%, respectively.…”

Section: Discussionsupporting

confidence: 92%

Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Shady

Fathy

Ali

et al. 2015

Open Access Maced J Med Sci

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BACKGROUND:In developing countries, Helicobacter pylori (H. pylori) infection is mainly acquired during childhood and may be a predisposing factor for peptic ulcer or gastric cancer later in life. Noninvasive diagnostic tools are particularly useful in children for screening tests and epidemiological studies. Data on serologic testing of children are lacking. Accurate noninvasive tests for diagnosing Helicobacter pylori infection in children are strongly required.AIM:The aim of this study was to evaluate the performance of a serological test (serum IgG antibody for H. pylori) in Egyptian children with recurrent abdominal pain necessitating endoscopy.SUBJECTS AND METHODS:One hundred children, referred to the endoscopy unit at Mansoura University. Upper endoscopy was done for each with rapid urease test (RUT) and histological examination as the gold standard test for detection of H. pylori infection. Serum samples were collected for detecting IgG for H. pylori infection.RESULTS:The mean age of the subjects included in the study was 7.23 ± 1.94 year. Serological test (IgG to H. pylori) was positive in 60% of all cases. A highly significant association between the standard test and the serological test at a cutoff > 10 U/ml at p = 0.001 were detected for the diagnosis of H. pylori infection. The sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for the IgG antibody a cutoff > 10 U/ml, were 96.5%, 93%, 13.83, 0.038 respectively.CONCLUSION:Serum IgG antibody to H. pylori infection has a high diagnostic value and can be considered as a suitable and reliable noninvasive test for detection of H. pylori infection.

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Section: Discussionsupporting

confidence: 92%

Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Shady

Fathy

Ali

et al. 2015

Open Access Maced J Med Sci

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“…Our results are also in disagreement with some results obtained even in different areas of the world, by immunocromatographic assay (4,9,18) . On the other hand, our results are similar to results achieved in Egypt (1,5) . Egypt has a high prevalence of H. pylori infection.…”

Section: Discussionsupporting

confidence: 81%

“…These tests do not need endoscopy and biopsy. Due to the character invasive of endoscopy and biopsy, there is a growing interest in the use of non-invasive methods (1) . Among the non-invasive methods, urea breath test is the most reliable due to its high sensitivity and specificity.…”

Section: Introductionmentioning

confidence: 99%

Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Nora

Hörner

Carli

et al. 2016

Arq. Gastroenterol.

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-Background -The diagnosis of H. pylori infection can be performed by non-invasive and invasive methods.The identification through a fecal antigen test is a non-invasive, simple, and relatively inexpensive test. ) and negative predictive value 73,2% (CI95% 67.5-77.6); Positive likelihood ratio was 4.7 (CI95% 2.9-7.9) and Negative Likelihood Ratio 0.4 (CI95% 0.3-0.5). The prevalence odds ratio for a positive test was 12.3 (CI95% 5.7-26.3). The index kappa between FAT and histology/urease test was 0.53 (CI95% 0.39-0.64). Conclusion -Immunochromatographic FAT is less expensive than the other methods and readily accepted by the patients but its diagnostic performance does not recommend its use in the primary diagnosis, when the patient may have an active infection.

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Non-invasive diagnostic tests forHelicobacter pyloriinfection

Best

Takwoingi

Siddique

et al. 2018

Cochrane Database of Systematic Reviews

153

130

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In people without a history of gastrectomy and those who have not recently had antibiotics or proton ,pump inhibitors, urea breath tests had high diagnostic accuracy while serology and stool antigen tests were less accurate for diagnosis of Helicobacter pylori infection.This is based on an indirect test comparison (with potential for bias due to confounding), as evidence from direct comparisons was limited or unavailable. The thresholds used for these tests were highly variable and we were unable to identify specific thresholds that might be useful in clinical practice.We need further comparative studies of high methodological quality to obtain more reliable evidence of relative accuracy between the tests. Such studies should be conducted prospectively in a representative spectrum of participants and clearly reported to ensure low risk of bias. Most importantly, studies should prespecify and clearly report thresholds used, and should avoid inappropriate exclusions.

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Evaluation of Noninvasive Versus Invasive Techniques for the Diagnosis of Helicobacter pylori Infection

Abstract: Among the noninvasive methods for diagnosis of H. pylori infection, the 3 methods used in this study recorded promising results, including good sensitivity, which was the highest in the serum antibody test, whereas the stool-PCR test recorded excellent specificity.

Cited by 7 publications

References 28 publications

Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Comparison of Serum IgG Antibody Test with Gastric Biopsy for the Detection of Helicobacter Pylori Infection among Egyptian Children

Is the Immunocromatographic Fecal Antigen Test Effective for Primary Diagnosis of Helicobacter Pylori Infection in Dyspeptic Patients?

Non-invasive diagnostic tests forHelicobacter pyloriinfection

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