Evaluation of non-palpable thyroid nodules by ultra sound guided fine needle aspiration cytology

Al-Sindi, Khalid; Bukhari, Mulazim Hussain; Saba, Kanwal; Ali, Wajid; Arshad, Madiha; Zaidi, Nasir Raza

doi:10.4236/ns.2013.52032

Cited by 3 publications

(7 citation statements)

References 23 publications

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“…In our study most of the malignant lesion was papillary carcinoma (9), rest are follicular carcinoma (6) and medullary carcinoma (1%). (Table 2&4).…”

Section: Resultssupporting

confidence: 47%

“…2013.reported that all of their false positive cases were follicular adenoma. Though false positive cases are much lower in USG guidance 9 . Mustafa et al2006 reported 33.3% false positive cases in palpation guided or free hand FNAC where as in USG guidance FNAC it was much lower (25%).…”

Section: Resultsmentioning

confidence: 94%

“…Lack of health education, more consumption of goitrogen may be the cause of higher goitrogenesis in rural areas. 9 . Major problems associated with free hand FNAC are significant false negatives (missed neoplasms) and difficulties in accurate identification of follicular lesions leading to wrong FNAC diagnoses 10 .…”

Section: Resultsmentioning

confidence: 99%

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Correlation of Ultrasonography Guided Fine Needle Aspiration Cytology with Postoperative Histopathology in Diagnosis of Thyroid Nodule

Sayied

Choudhury

Bithi³

et al. 2021

Bangladesh J of Otorhinolaryngology

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Background: Fine-needle aspiration cytology (FNAC) is recommended as a decisive diagnostic step in the workup of patients with nodular thyroid disease. Unfortunately, FNAC can miss malignancies in smaller and deeper nodule. Ultrasound guided FNAC (US-FNAC) can reduce this error in suspicious thyroid nodule. Objectives: To find out the correlation of USG guided FNAC with postoperative histopathology in diagnosis of thyroid nodule. Methods: After obtaining clearance and approval from Institutional Review Board, all 45 patients of thyroid nodule who were admitted in the Department of Otolaryngology – Head & Neck surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from April 2017 to August 2018 and had fulfilled the inclusion and exclusion criteria were selected for the study. Each patient was assessed before surgery by USG guided FNAC and post operatively by histopathology. Results: In this study mean age of the respondents was 33.33 yearswith SD±10.84. Male female ration was 1:5.4. USG guided FNAC was reported by ‘The Bethesda System for Reporting Thyroid Cytopathology’ (TBS-RTC).Of the 45 specimens 2 samples were nondiagnostic or unsatisfactory (Class I), 26 samples were benign (Class II), 2 samples were showing Atypia of Undetermined Significance or Follicular lesion of Undetermined Significance (Class III), 6 were showing follicular neoplasm or suspicious for a follicular neoplasm (Class IV), 5 samples were suspicious for malignancy (Class V) and 4 samples were positive for malignancy (Class VI). On comparison of ultrasound guided FNAC with histopathology the sensitivity for correct diagnosis was 94%, specificity was 93%, positive predictive value was 88%, negative predictive value was 96% and accuracy was 93%. Pearson’s correlation coefficient was 0.85 which is very strong for positive relationship. Conclusion: USG guided FNAC is the most accurate method for diagnostic evaluation of thyroid nodules. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 36-43

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“…In our study most of the malignant lesion was papillary carcinoma (9), rest are follicular carcinoma (6) and medullary carcinoma (1%). (Table 2&4).…”

Section: Resultssupporting

confidence: 47%

Section: Resultsmentioning

confidence: 94%

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Correlation of Ultrasonography Guided Fine Needle Aspiration Cytology with Postoperative Histopathology in Diagnosis of Thyroid Nodule

Sayied

Choudhury

Bithi³

et al. 2021

Bangladesh J of Otorhinolaryngology

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“…al assessed 200 specimens according to BSRTC and found a sensitivity and specificity of 93% and 86% respectively. Only 6 cases in their series could be categorized as Bethesda 3 category, out of which 2 were malignant [ 15 ]. Bongiovanni et.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of Bethesda system for reporting thyroid cytopathology: an institutional perspective

et al. 2014

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IntroductionThyroid swelling is common problem among South Asian women. Although benign nodules far outnumber cancerous lesions, the risk of malignancy needs to be evaluated preoperatively for which fine needle aspiration cytology (FNAC) is widely used. Bethesda system for reporting thyroid cytopathology (BSRTC) was introduced to streamline the reporting of thyroid aspirates. We aimed to evaluate the disease spectrum of thyroid cytopathology and correlation of BSRTC with final histopathology in our setup.MethodsThe study was conducted at Histopathology department of Liaquat National Hospital, Karachi, involving 528 patients with thyroid swelling who underwent FNAC. Out of these 528 cases, 61 patients subsequently underwent surgical excision. Results of final histopathology were correlated with cytologic diagnosis.ResultsMean age of the patients included in the study was 39.7 ± 13(14–84) and male to female ratio was 1:3.6. Out of total 528 cases, 403 cases were diagnosed as benign (Bethesda 2) and 67 were Bethesda 3 (follicular lesion of undetermined significance, FLUS) while 22 cases were categorized as either malignant or suspicious for malignancy (Bethesda 6 and 5). Histopathologic correlation was done in 61 cases. For Bethesda 5 and 6 categories, 100% concordance was found, however for Bethesda 2 category, 5 out of 45 cases were found to have malignant diagnosis on final histopathology. The incidence of malignancy in Bethesda categories 2 through 4 were 11.1%, 33.4%, 25%, 100% and 100% respectively. Overall accuracy of FNA cytology was 80.3% with 64.3% sensitivity and 85.1% specificity.ConclusionOur study validated the accuracy of BSRTC in our setup. Therefore we recommend routine use of BSRTC for reporting thyroid cytopathology for initial workup of patients with thyroid nodule. However, risk of malignancy was found to be significantly high in Bethesda 3 category to warrant further workup including ultrasound/thyroid scan in addition to repeat FNAC.

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“…Thyroid nodules are common in clinical practice [2,3,17,21,23,28]. Their clinical importance is primarily related to the need to exclude a thyroid malignancy [6,21,22,28]. The risk of malignancy is similar for solitary nodules and multinodular goiters [18].…”

Section: Introductionmentioning

confidence: 99%

Role of sonographic features in predicting the malignant potential of thyroid nodules

Alawi¹,

Salem²,

Hudeel³

2019

Univ. Aden J. Nat. and Appl. Sc.

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However, while thyroid nodules are common, thyroid malignancy is relatively rare, constituting about 1% of all malignancies. The main point of the approach of the thyroid nodule is the detection of the malignant nodules and deciding for the surgical treatment. Ultrasonography (US) plays a crucial role in the diagnostic management of thyroid nodules. The aim was to assess the reliability of using hypoechoic, solid and ill-defined margin as independent predictors for the identification of malignant thyroid nodules on US. We retrospectively analysed the three suspicious US features of malignancy for 145 patients with 255 thyroid nodules who underwent thyroid resection. We used histological results as gold standard reference test. Of the 255 surgical resected nodules; hypoechoic nodules had a sensitivity of 66.7%, and positive predictive value (PPV) of 8.7%. Solid nodules had a sensitivity of 33.3% and PPV of 3.7%. Ill-defined margins nodules had a sensitivity of 66.7% and PPV of 6.9% in predicting malignancy. The present study adds further evidence on the poor PPV in our results, indicated, that individual US features are not reliable used as independent predictors for the identification of malignant potential thyroid nodules on US.

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Evaluation of non-palpable thyroid nodules by ultra sound guided fine needle aspiration cytology

Cited by 3 publications

References 23 publications

Correlation of Ultrasonography Guided Fine Needle Aspiration Cytology with Postoperative Histopathology in Diagnosis of Thyroid Nodule

Correlation of Ultrasonography Guided Fine Needle Aspiration Cytology with Postoperative Histopathology in Diagnosis of Thyroid Nodule

Diagnostic accuracy of Bethesda system for reporting thyroid cytopathology: an institutional perspective

Role of sonographic features in predicting the malignant potential of thyroid nodules

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