Evaluation of non-isothermal thermal degradation kinetics of lavender essential oil (Lavandula angustifólia)

Pimentel, Kilma Gabrielle Barbosa; Fônseca, Naara Felipe da; Silva, João Victor Belo da; Medeiros, Ana Cláudia Dantas de; Fernandes, Felipe Hugo Alencar

doi:10.1007/s10973-022-11767-w

Cited by 2 publications

(2 citation statements)

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“…Essential oils, known for their hydrophobic behavior, have been reported as hemolytic [ 53 ]. Linalool, the main component of lavender oil, causes erythrocyte lysis and is thus considered hemolytic [ 53 , 54 ]. Surfactants Tween 20 and Span 80 can also be hemolytic due to their fatty acid-based chemical characteristics, which damage erythrocyte membranes [ 52 , 55 ].…”

Section: Discussionmentioning

confidence: 99%

“…The CW49–lavender emulsion and the lavender emulsion inhibited the growth of both bacterial strains, thus demonstrating bacteriostatic behavior. Research suggests that the antibacterial activity of essential oils results from the action of monoterpene and sesquiterpene components on the cell membrane [ 54 ]. In particular, lavender oil can disrupt membranes and cause bacterial-cell shrinkage due to its lipophilic components, leading to bacterial death [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

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Enhancing Wound Healing: A Novel Topical Emulsion Combining CW49 Peptide and Lavender Essential Oil for Accelerated Regeneration and Antibacterial Protection

et al. 2023

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Wound healing is a complex process involving blood cells, extracellular matrix, and parenchymal cells. Research on biomimetics in amphibian skin has identified the CW49 peptide from Odorrana grahami, which has been demonstrated to promote wound regeneration. Additionally, lavender essential oil exhibits anti-inflammatory and antibacterial activities. Given these considerations, we propose an innovative emulsion that combines the CW49 peptide with lavender oil. This novel formulation could serve as a potent topical treatment, potentially fostering the regeneration of damaged tissues and providing robust antibacterial protection for skin wounds. This study investigates the physicochemical properties, biocompatibility, and in vitro regenerative capacity of the active components and the emulsion. The results show that the emulsion possesses appropriate rheological characteristics for topical application. Both the CW49 peptide and lavender oil exhibit high viability in human keratinocytes, indicating their biocompatibility. The emulsion induces hemolysis and platelet aggregation, an expected behavior for such topical treatments. Furthermore, the lavender-oil emulsion demonstrates antibacterial activity against both Gram-positive and Gram-negative bacterial strains. Finally, the regenerative potential of the emulsion and its active components is confirmed in a 2D wound model using human keratinocytes. In conclusion, the formulated emulsion, which combines the CW49 peptide and lavender oil, shows great promise as a topical treatment for wound healing. Further research is needed to validate these findings in more advanced in vitro models and in vivo settings, potentially leading to improved wound-care management and novel therapeutic options for patients with skin injuries.

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