Evaluation of non-conventional polar modifiers on immobilized chiral stationary phases for improved resolution of enantiomers by supercritical fluid chromatography

Insights into chiral recognition mechanisms in supercritical fluid chromatography V. Effect of the nature and proportion of alcohol mobile phase modifier with amylose and cellulose tris-(3,5-dimethylphenylcarbamate) stationary phases

“…When traditional modifiers are not sufficient, non-traditional solvents (as dichloromethane, tetrahydrofuran, ethyl acetate, etc.) can be envisaged [19,20]. They are compatible with immobilized and bonded CSP, as a second approach to improve solubility and obtain adequate selectivity.…”

Liquid Chromatography Enantioseparations of Halogenated Compounds on Polysaccharide‐Based Chiral Stationary Phases: Role of Halogen Substituents in Molecular Recognition

“…Moreover, the authors highlighted that the retention properties of the PPIs can be modulated in a dual way (hydrophilic interaction liquid chromatography (HILIC)/RPLC) by means of a suitable use of the water content in pure ACN or ACN-rich organic mixture. 34 As reported by DaSilva et al, lansoprazole was baseline-resolved on all six columns using mixtures of nonconventional polar modifiers such as DCM, methyl THF, MTBE with MeOH. 34 As reported by DaSilva et al, lansoprazole was baseline-resolved on all six columns using mixtures of nonconventional polar modifiers such as DCM, methyl THF, MTBE with MeOH.…”

Determination of Chemical and Enantiomeric Purity of α‐Amino Acids and their Methyl Esters as N‐Fluorenylmethoxycarbonyl Derivatives Using Amylose‐derived Chiral Stationary Phases

“…12,18 Based on the overall results from the nine analytes, the most successful chiral CSP was CSP 1 having amylose tris (3-chlorophenylcarbamate) as a chiral selector except for two analytes of amino acids (entries 2 and 9, Table 1). The enantiomeric separation results of nine α-amino acids and methyl esters as N-FMOC derivatives with normal phase eluents on three newly developed immobilized CSPs are summarized in Tables 1-3.…”

“…3,[8][9][10][11][12][13][14][15] In particular, amylose tris phenylcarbamate represents a major group of chiral selectors used in the preparation of CSPs for the liquid chromatographic separation of enantiomers. [17][18][19] Recently, three covalently bonded amylose phenylcarbamate-derived CSPs (Chiralpak ID, IE, and IF) were developed and have been shown in some applications. [17][18][19] Recently, three covalently bonded amylose phenylcarbamate-derived CSPs (Chiralpak ID, IE, and IF) were developed and have been shown in some applications.…”