Evaluation of nitazoxanide as a novel drug for the treatment of acute and chronic toxoplasmosis

Effect of nitazoxanide and spiramycin metronidazole combination in acute experimental toxoplasmosis

“…SMZ-TMP was the second successful combination; SP came third, while NTZ was the least effective in parasite load reduction within the examined tissues which may be due to the low dose used. El-Kowranya et al (2019) reported that NTZ had significant treatment effect on acute and chronic Toxoplasma gondii (ME49 strain) [39]. However, there are no previously published reports regarding the effect of NTZ against the RH strain of T. gondii in a murine model.…”

Amelorative and Hepatoprotective Effects of Fisetin on Acute Murine Toxoplasmosis

“…PYR were purchased (Sigma-Aldrich) and diluted in CMC as 0.5gm/100 ml, and given orally, in combination as 12.5 or 250 mg/kg/day, respectively for 5 days. Treatment started on the infection day up to 5 days (El Kowrany et al, 2019).…”

A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19

“…1 ), for instance, acetylbenzamide or salicylamide moiety acts as an analgesic, antioxidant, anti-infective (against bacteria, fungi, parasite and viruses), affects interleukin production, regulates immune responses, antipolymerase activity against hepatitis virus, blocks influenza viral entry and host cell membrane fusion ( Krátký and Vinšová, 2011 ). The nitrothiazole moiety exhibits antiprotozoal, antiproliferative, antiinfective effect ( Colín-Lozano et al, 2017 ), control oxidative stress ( El-Kowrany et al, 2019 ) and disrupts pyruvate: ferredoxin oxidoreductase dependent redox reactions essential for anaerobic protozoa and bacteria for their energy metabolism and survival ( Hemphill et al, 2006 ; Kumar et al, 2014 ; Rossignol, 2009 ). Thus it can be postulated that nitazoxanide can inhibit various stages of the virus multiplication cycle and also potentiate host innate immunity ( Martins-Filho et al, 2020 ; Padmanabhan, 2020 ).…”