Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass

Bakry, Ahmed; Takahashi, Hidekazu; Otsuki, Masayuki; Tagami, Junji

doi:10.1016/j.dental.2013.12.002

Cited by 71 publications

(83 citation statements)

References 21 publications

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“…Erosive-like lesions do not exhibit the subsurface porosity, but irreversible enamel surface loss. A method has been described recently to treat erosive-like lesions where applying a 45S5 BAG-phosphoric-acid gel onto the enamel surface followed directly by placing a layer of bonding agent, preserves the 45S5 gel in contact with enamel surface for 24 h until the bioactive process matures [4].…”

Section: Microscopy Imagingmentioning

confidence: 99%

“…The enamel white spot lesion (WSL) results from the physical changes occurring in enamel due to the caries process before it has reached the enamel-dentin junction (EDJ) [2]. Different protocols have been described to remineralize enamel WSLs including bioactive glass (BAG) 45S5 [3][4][5][6][7]. BAG 45S5 is an inorganic amorphous, calcium, sodium phosphosilicate material which contains fivefold ratio of Ca/P [8].…”

Section: Introductionmentioning

confidence: 99%

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Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

et al. 2015

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Section: Microscopy Imagingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

et al. 2015

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“…This layer showed resistance to abrasion when tested using 6,000 cycles of tooth-brush abrasion under a load of 250 g which simulates the harsh conditions of abrasion in the oral cavity 22) . The profit of using non-thermal or cold plasmas for surface modification is that the surface properties of materials can be selectively boosted while their bulk properties stay unaffected 38) .…”

Section: Discussionmentioning

confidence: 99%

“…Placing and curing a layer of adhesive over the bioglass paste allowed it to stay in contact with the enamel substrate for 24 h without being washed off. It has been shown that the bioactive reaction takes at least 2 h to complete 6,22) . The application of a hydrophilic HEMA; self-etching adhesion promoter coat, did not seem to limit the diffusion of water and ions from the remineralizing solution through the resin coat layer to the bioglass and enamel interface.…”

Section: Discussionmentioning

confidence: 99%

“…Point one grams of 45S5 bioglass powder; composition and procedure are mentioned in Table 2 21) (44-μm average particle size, containing 24.5 wt% Na2O, 24.4 wt% CaO, 6 wt% P2O5, and 45 wt% SiO2) was mixed with a spatula on a glass slab with 0.2 mL of 50 wt% phosphoric acid (Fisher Scientific Company, Fairlawn, New Jersey, USA) for 1 min to form a paste 22) . This slurry paste was applied to the demineralized specimens of Groups B and PB using a micro-brush (Disposable Applicators, Size M-silver Lot: 185522, 3M ESPE, St. Paul, MN, USA) with a rotational rubbing motion for 1 min.…”

Section: Bioglass Applicationmentioning

confidence: 99%

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Remineralizing effect of cold plasma and/or bioglass on demineralized enamel

El-Wassefy

2017

Dental Materials Journal

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This study investigated the combining effect of cold plasma and bioglass-phosphoric acid paste on demineralized enamel. Fifty bovine incisors' enamel specimens were challenged by a demineralization solution of pH 4.47 for 72 h. Specimens were divided into five groups: (I) Control, demineralized enamel (C); (II) Demineralized enamel treated with fluoride varnish (F); (III) Cold plasma application to demineralized enamel (P); (IV) Demineralized enamel treated with bioglass paste (B); (V) Application of bioglass paste to cold plasma-treated demineralized enamel (PB). Specimens were then immersed in remineralizing solution for 24 h, before being examined with micro-computed tomography (micro-CT), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and cross-sectional micro-hardness measurement. The results showed that; treating demineralized enamel with cold plasmas before bioglass application ensued a significant high mineral volume recovery and micro-hardness of demineralized region. It can be concluded that cold plasmas may improve the remineralization of bioglass on demineralized enamel.

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Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

2021

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Enamel, once formed, loses the ability to regenerate due to the loss of the formative ameloblasts. It is subjected to constant damaging events due to exposure to external agents and oral microbiomes. An enamel remineralization process targets to replenish the lost ionic component of the enamel through a multitude of methods. Enamel remineralization is highly challenging as it has a complex organized hierarchical microstructure. Hydroxyapatite nanocrystals of the enamel vary in size and orientation along alignment planes inside the enamel rod. The inability of the enamel to remodel unlike other mineralized tissues is another substantial deterrent. One of the wellknown biomaterials, bioglass (BG) induces apatite formation on the external surface of the enamel in the presence of saliva or other physiological fluids. Calcium, sodium, phosphate, and silicate ions in BG become responsive in the presence of body fluids, leading to the precipitation of calcium phosphate. Studies have also demonstrated the bactericidal potential of BG against Streptococcus mutans biofilms. The anticariogenicity and antibacterial activity were found to be enhanced when BG was doped with inorganic ions such as F, Ag, Mg, Sr, and Zn. Due to the versatility of BG, it has been combined with a variety of agents such as chitosan, triclosan, and amelogenin to biomimic remineralization process. Key strategies that can aid in the development of contemporary enamel remineralization agents are also included in this review.

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Evaluation of new treatment for incipient enamel demineralization using 45S5 bioglass

Cited by 71 publications

References 21 publications

Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

Surface pre-conditioning with bioactive glass air-abrasion can enhance enamel white spot lesion remineralization

Remineralizing effect of cold plasma and/or bioglass on demineralized enamel

Role of bioglass in enamel remineralization: Existing strategies and future prospects—A narrative review

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