Evaluation of New Technologies in Gastrointestinal Endoscopy

Akarsu, Murat; Akarsu, Cevher

doi:10.4293/jsls.2017.00053

Cited by 25 publications

(19 citation statements)

References 37 publications

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“…More than 90% of GC cases are reportedly revealed by biopsy-associated endoscopy. The increased use of endoscopy, thanks also to the revolutionary developments that have occurred recently and that have produced new, more sophisticated systems, has allowed highlighting of the “early” GC[209,210]. Ultrasonographic endoscopy is useful for TNM staging of GC patients, having a high diagnostic value.…”

Section: Resultsmentioning

confidence: 99%

Precision medicine in gastric cancer

Bonelli

Borrelli

Tuccillo

et al. 2019

WJGO

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Gastric cancer (GC) is a complex disease linked to a series of environmental factors and unhealthy lifestyle habits, and especially to genetic alterations. GC represents the second leading cause of cancer-related deaths worldwide. Its onset is subtle, and the majority of patients are diagnosed once the cancer is already advanced. In recent years, there have been innovations in the management of advanced GC including the introduction of new classifications based on its molecular characteristics. Thanks to new technologies such as next-generation sequencing and microarray, the Cancer Genome Atlas and Asian Cancer Research Group classifications have also paved the way for precision medicine in GC, making it possible to integrate diagnostic and therapeutic methods. Among the objectives of the subdivision of GC into subtypes is to select patients in whom molecular targeted drugs can achieve the best results; many lines of research have been initiated to this end. After phase III clinical trials, trastuzumab, anti-Erb-B2 receptor tyrosine kinase 2 (commonly known as ERBB2) and ramucirumab, anti-vascular endothelial growth factor receptor 2 (commonly known as VEGFR2) monoclonal antibodies, were approved and introduced into first- and second-line therapies for patients with advanced/metastatic GC. However, the heterogeneity of this neoplasia makes the practical application of such approaches difficult. Unfortunately, scientific progress has not been matched by progress in clinical practice in terms of significant improvements in prognosis. Survival continues to be low in contrast to the reduction in deaths from many common cancers such as colorectal, lung, breast, and prostate cancers. Although several target molecules have been identified on which targeted drugs can act and novel products have been introduced into experimental therapeutic protocols, the overall approach to treating advanced stage GC has not substantially changed. Currently, surgical resection with adjuvant or neoadjuvant radiotherapy and chemotherapy are the most effective treatments for this disease. Future research should not underestimate the heterogeneity of GC when developing diagnostic and therapeutic strategies aimed toward improving patient survival.

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Section: Resultsmentioning

confidence: 99%

Precision medicine in gastric cancer

Bonelli

Borrelli

Tuccillo

et al. 2019

WJGO

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“…The CE displays images obtained using blue light similar to NBI and reveals the superficial and vascular patterns of the studied area. TE improves identification of tiny mucosal structures and subtle changes in color [18,19].…”

Section: I-scan Technology Was Developed By Pentax Inc (Tokyo Japan)mentioning

confidence: 99%

New Technologies and Techniques in Gastrointestinal Endoscopy

Moura¹

2018

IOD

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“…A large array of therapeutic alternatives has positioned endoscopy as the cornerstone for most of the diseases of the gastrointestinal tract and gradually has become a technique that may obviate surgery in some situations. From basic tissue harvesting to real-time confocal microscopic assessment [4] or from palliative therapeutic armamentarium to procedures more close tied to surgery procedures, gastrointestinal endoscopy has become more and more popular and along with its advantages or challenges has penetrated the gastroenterology community, becoming the touchstone for this medical specialty [5].…”

Section: Introductionmentioning

confidence: 99%