Evaluation of new Seawater-based Mouth Rinse Versus Chlorhexidine 0.2% Reducing Plaque and Gingivitis Indexes. A Randomized Controlled Pilot Study

Abstract

For a long time, Chlorhexidine digluconate (CHX) has been considered the most used mouth-rinse for reducing plaque and gingivitis. Sea4® Encias is a new seawater-based mouth rinse with a similar action to CHX. Its prolonged use produces fewer side effects. This study compared the effects of two oral rinses: Chlorhexidine 0.20% and Sea 4® Encias (seawater) for reducing plaque and gingivitis indices. This double-blind crossover study recruited and monitored 93 volunteer dental students, hygienists and doctors from the Universidad Católica de Murcia (UCAM), for 1 month, and compared the efficacy of Chlorhexidine 0.20% (Group A); Sea4® Encías (Group B); and a placebo saline solution (Group C) mouth-rinses for reducing plaque and gingivitis indices. Plaque and gingival inflammation (Löe and Silness test) were evaluated at baseline and after each study stage. Group A reduced plaque growth and gingivitis significantly compared with Groups B and C; Group B was more effective than Group C. The mean P.I. decreased similarly in groups A and B. However, Group A showed the statistically significant value compared with other groups. Group A and group B, showed greater reduction in Gingival Indexes compared with group C. The Sea4 mouthwash showed better inhibitory activity on plaque (1.32 ± 0.22) compared with CHX (1.97 ± 0.34) and saline (2.78 ± 0.11). Sea4 Encias and Chlorhexidine 0.20% mouth-rinses significantly reduce plaque growth and G.I. compared with saline mouth-rinse; Sea4 Encías mouth-rinse is more effective against plaque regrowth than Chlorhexidine in this pilot study.

Is Chlorhexidine in Dentistry an Ally or a Foe? A Narrative Review

“…Possible alternatives to chlorhexidine-based rinses include all natural polyherbal mouthwashes [43], probiotics [44], seawater-based mouthwash [45], or Beta-Cyclodextrin + Citrox [46]; however, all these solutions need more in-depth studies.…”

Efficacy of Olive Leaf Extract Mouthwash on Clinical and Inflammatory Parameters of Gingival Inflammation in Relation to Chlorhexidine in Acute Gingivitis Serum Patients

“…In the treatment of acute gingivitis, a related process could be found in the effect of 0.12 % CHX mouthwash after scaling and polishing, result in the reduction of clinical periodontal parameters such as PI, GI, and BOP compared to scaling and polishing alone [26]. The decline result may be due to CHX mouthwash's positive effect on plaque formation by its antibacterial activity, which greatly minimized and give controls for gingival inflammation in patients with poor oral hygiene [27]. The results showed no significant difference in the mean values of gingival indices between the chlorhexidine and OLE as mouthwashes [19].…”

Efficacy of Chamomile Mouthwash on Clinical And Serum Inflammatory Parameters in Relation to Chlorhexidine in Chronic Gingivitis Patients

“…These observations are consistent with other researchers' findings, on the effects of matrica mouthwash on bacterial plaque and gingival inflammation, which found that this mouthwash has a major impact on plaque accumulation, bleeding on probing, and gingival inflammation [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25].In the treatment of chronic gingivitis, a related process could be found in the effect of 0.12 % CHX mouthwash after scaling and polishing, leading to a reduction in clinical periodontal parameters such as PI, GI, and BOP compared to scaling and polishing alone [26]. The decline may be due to CHX mouthwash's positive effect on plaque formation by its antibacterial activity, which greatly decreases and controls gingival inflammation in patients with poor oral hygiene [27].The results showed no significant difference in the mean values of gingival indices between the chlorhexidine and chamomile as mouthwashes [19]. Nevertheless, the result showed that the plaque inhibitory effects of 0.12 % CHX were slightly greater than that of 1% of chamomile, this may be because chlorhexidine has a wide spectrum of action, acting on bacteria that are Gram positive and Gram negative.…”