Evaluation of New Measures of the Impact of Hypothyroidism on Quality of Life and Symptoms: The ThyDQoL and ThySRQ

McMillan, Carolyn; Bradley, Clare; Razvi, Salman; Weaver, Jolanta U.

doi:10.1111/j.1524-4733.2007.00232.x

Cited by 54 publications

(69 citation statements)

References 25 publications

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“…Dry skin was reported by 63% of the patients. This ranged from 39 to 95% in other studies reporting on symptoms in hypothyroidism (2,5,6,10,14,17). Hair loss was observed in 30% of all cases, but this symptom had a high diagnostic odds value because only 9% of euthyroid controls reported that complaint.…”

Section: Clinical Studymentioning

confidence: 93%

“…Other studies also report that tiredness/fatigue/lethargy was the most common of all symptoms in hypothyroidism (4,14,27,28,29,30). Interestingly, tiredness only ranked with the 11th highest LRC but the lowest LRK.…”

Section: Symptoms In Hypothyroidismmentioning

confidence: 94%

“…For example, we had no information on cold intolerance or decreased sweating (2,5,14,17,27,28). In a study by Watt et al (30), symptoms were ranked according to their individual importance, and cold intolerance was the third most compelling complaint.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

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Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

Carlé¹,

Pedersen²,

Knudsen³

et al. 2014

European Journal of Endocrinology

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Background: It is generally accepted that patients suffering from hypothyroidism may express few symptoms, but this has not been studied in a population-based study design. Objectives: To study the array of symptoms as they are reported in newly diagnosed overt autoimmune hypothyroidism using a population-based case-control design. Methods: Patients with new overt autoimmune hypothyroidism (nZ140) and their individually matched thyroid disease-free controls (nZ560) recruited from the same population underwent a comprehensive program and self-reported a number of symptoms. We identified the symptoms associated with overt hypothyroidism and calculated positive (LRC) and negative (LRK) likelihood ratios as well as diagnostic odds ratios (DORs) as measures for the association between disease state and symptoms. Results: Among 34 symptoms investigated, 13 symptoms were statistically overrepresented in hypothyroidism. Hypothyroid patients suffered mostly from tiredness (81%), dry skin (63%), and shortness of breath (51%). Highest DORs (95% CI) were reported for tiredness (5.94 (3.70-9.60)), hair loss (4.58 (2.80-7.51)), and dry skin (4.09 (2.73-6.16)). A hypothyroidismcomponent-score was defined as the number of hypothyroidism-associated symptoms (range: 0-13). LRC for participants with a hypothyroidism-component-score of 0 was 0.21 (0.09-0.39), meaning that the post-test probability was lowered to 21% of what it was before asking for symptoms. LRC for scores of 1-2/3/4-6/7-9/10-13 were: 0.47 (0.30-0.72)/1.16 (0.70-1.87)/1.90 (1.29-2.45)/3.52 (2.30-5.36)/6.29 (2.30-17.7). Conclusions: None of the individual symptoms of hypothyroidism had high LRs or DORs. Thus, neither the presence nor absence of any individual hypothyroidism symptom was reliable in the decision making of who should have their thyroid function tested. Therefore, even minor suspicion should lead to a blood test.

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Section: Clinical Studymentioning

confidence: 93%

Section: Symptoms In Hypothyroidismmentioning

confidence: 94%

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Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

Carlé¹,

Pedersen²,

Knudsen³

et al. 2014

European Journal of Endocrinology

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“…Several studies have examined patient quality of life (QoL) related to the thyroid disorders and evaluated this aspect before and after treatment. The majority of studies investigated the correlation between QoL and hormone changes [8][9][10]. One study highlighted the psychological changes rather than appearance or worsening of the tiredness or asthenia [11].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Scerrino¹,

Raspanti²,

Attard³

et al. 2017

Langenbecks Arch Surg

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Purpose Chronic asthenia (CA) is complained by some patients that have undergone thyroid surgery. We evaluate its impact in patients undergoing unilateral or bilateral thyroidectomy, the trend during a 1-year follow-up, and the possible risk factors. Methods A prospective, cohort study was carried out on 263 patients scheduled for thyroidectomy from 2012 and 2014. Exclusion criteria were as follows: Graves' disease, malignancies requiring radioiodine therapy, post-surgical hypoparathyroidism, laryngeal nerve palsy, abnormal pre-and postoperative thyroid hormone levels, and BMI outside the normal range. Demographics; smoking and alcoholism addiction; cardiac, pulmonary, renal, and hepatic failure; diabetes; anxiety; and depression were recorded. The Brief Fatigue Inventory (BFI) was used to evaluate CA and its possible association with these comorbidities 6 and 12 months after thyroidectomy. Results One hundred seventy-seven patients underwent total thyroidectomy (TT), 54 hemithyroidectomy (HT). Thirty-two patients were not recorded because of the onset of exclusion criteria. In the 6 months after thyroidectomy, in the TT group, 64 patients (36.16%) reported an impairment in the BFI score and only 1 in the TL group. The mean BFI score changed from 1.663(±1.191) to 2.16 (±11.148) in the TT group, from 1.584 (±1.371) to 1.171 (±1.093) in the TL group (p < 0.001). No further significant variations in BFI were reported 1 year after surgery. Conclusions CA worsened after TT, but not after HT. Apart from operative procedure itself, no other risk factor was found be significantly associated with post-thyroidectomy asthenia. Further investigation is needed to determine the causes of CA.

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“…Basic clinical data, consisting of serum thyrotropin (TSH) and free thyroxine (fT4) levels, clinical hypothyroidism scores (7,8), and underactive thyroid-dependent quality of life and perceived impact scales (ThyDQoL and ThySRQ) (9), were collected at each visit. TSH was measured using immunochemiluminescence on a Beckman Coulter Unicell Dxi platform.…”

Section: Study Measuresmentioning

confidence: 99%

Reversible Cognitive, Motor, and Driving Impairments in Severe Hypothyroidism

Smith

Grondin

LeMaster

et al. 2015

Thyroid

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Transient profound hypothyroidism is characterized by reversible depression, decreased fine-motor performance, slowed reaction times, and decreased processing speed. These data represent new empirical evidence that support the recommendation that complex activities requiring rapid responses, such as operating motor vehicles, should be avoided during hypothyroidism. This has broader implications regarding functional impairments and risk to public health.

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Evaluation of New Measures of the Impact of Hypothyroidism on Quality of Life and Symptoms: The ThyDQoL and ThySRQ

Abstract: Both the ThyDQoL and ThySRQ are highly acceptable to patients with hypothyroidism and have good internal consistency reliability. Their sensitivity to change now needs to be evaluated in clinical trials.

Cited by 54 publications

References 25 publications

Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

Hypothyroid symptoms and the likelihood of overt thyroid failure: a population-based case–control study

The prevalence of post-thyroidectomy chronic asthenia: a prospective cohort study

Reversible Cognitive, Motor, and Driving Impairments in Severe Hypothyroidism

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