Evaluation of New Approaches to Depression Treatment Using an Animal Model of Pharmacoresistant Depression
Alexandra Zvozilova,
Stanislava Bukatova,
Romana Koprdova
et al.
Abstract:Depression is emerging as the predominant psychiatric disorder globally. Despite the wide availability of antidepressants, up to 30% of patients exhibit poor response to treatment, falling into the category of treatment-resistant depression (TRD). This underscores the need for the exploration of novel therapeutic options. Our work aims to study the effect of chronic administration of the pyridoindole derivative SMe1EC2M3, a triple reuptake inhibitor, and the combination of zoletil and venlafaxine under conditi… Show more
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