Evaluation of neutrophilia as a prognostic factor in dogs with multicentric lymphoma treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone–based chemotherapy protocol

Abstract

To determine whether, in dogs with naïve multicentric lymphoma, neutrophilia at the time of initial diagnosis was associated with progression-free survival time (PFST) or overall response rate (ie, percentage of dogs with a complete or partial remission) and whether the initial neutrophil-to-lymphocyte ratio was associated with PFST. ANIMALS 30 dogs with multicentric lymphoma and neutrophilia (including 16 treated with a cyclophosphamide, doxorubicin, vincristine, and prednisone [CHOP]-based protocol) and 37 historical control dogs without neutrophilia treated with a CHOP-based protocol. PROCEDURESMedical records were reviewed, and PFSTs and responses were documented. RESULTSMedian PFST for the 16 dogs with neutrophilia treated with a CHOP-based protocol (70 days; range, 0 to 296 days) was significantly shorter than that for the 37 control dogs without neutrophilia (184.5 days; range, 23 to 503 days), and the overall response rate for dogs with neutrophilia (12/16 [75%]) was significantly lower than the rate for dogs without neutrophilia (36/37 [97%]). However, when all dogs in the study and control populations were considered together, the neutrophil-to-lymphocyte ratio at the time of diagnosis was not significantly associated with PFST. CONCLUSIONS AND CLINICAL RELEVANCEResults suggested that neutrophilia at the time of initial diagnosis may suggest a poorer prognosis in dogs with multicentric lymphoma. Prospective investigation into the role of neutrophils in the peripheral circulation and tumor microenvironment of cancer-bearing patients is warranted.

Review of Canine Lymphoma Treated with Chemotherapy—Outcomes and Prognostic Factors

“…There were an additional 26 papers including 33 groups and 1606 cases [11,32,35,36,52,57,62,78,82,84,86,87,95,96,101,[104][105][106]119,128,129,133,136,151,161,171] treated with a CHOP-like protocol where the location or distribution of the lymphoma were not clearly defined. Two papers included only B-cell lymphoma [84,161] with the remainder either not specifying the immunotype or including a mixture.…”

“…It is likely that most of the cases in these papers were multicentric or nodal. One paper reported only survival time [78], four only remission duration [32,86,133,136], and one reported only remission rates [82], with the remainder reporting both remission and survival durations. The outcomes are listed in Table 3.…”