Evaluation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with lichen planus

An, İsa; Uçmak, Derya; Öztürk, Murat

doi:10.5455/annalsmedres.2018.08.169

Cited by 7 publications

(26 citation statements)

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“…MPV is the most widely used measure of platelet size and is considered an in vivo indicator of platelet reactivity as large platelets are more metabolically and enzymatically active. Increased MPV is considered as an independent risk factor for acute myocardial infarction, hyperlipidemia and diabetes 7,27,28 …”

Section: Discussionmentioning

confidence: 99%

“…Platelet activation has been reported to play a role in the pathogenesis of psoriasis 10,26 . In recent years, the PLR value obtained by dividing the platelet count by lymphocyte number has been shown to have a significant effect on the pathogenesis of systemic inflammatory response and has been shown to be used as a marker of inflammation 6,7 …”

Section: Discussionmentioning

confidence: 99%

“…The inflammatory nature of the disease is due to overexpression of tumor necrotising factor (TNF)‐α, interferon (IFN)‐gama and various proinflammatory cytokines 1,4,5 . In recent years, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) have been shown to be important indicators of systemic inflammation 6‐9 . In some studies, it was found that NLR, PLR and MPV were higher in psoriasis patients compared to healthy control group 10,11 .…”

Section: Introductionmentioning

confidence: 99%

“…1,4,5 In recent years, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) have been shown to be important indicators of systemic inflammation. [6][7][8][9] In some studies, it was found that NLR, PLR and MPV were higher in psoriasis patients compared to healthy control group. 10,11 In addition, these inflammatory parameters have been shown to decrease in patients with psoriasis after treatment with biological agents such as adalimumab, etanercept, infliximab and ustekinumab.…”

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confidence: 99%

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The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study

Aksoy

Ayhan

et al. 2021

Int J Clin Pract

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Aim Psoriasis is a common chronic inflammatory disease of the skin with remission and relapses. The aim of this study was to investigate the change in inflammatory parameters such as neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients receiving secukinumab treatment for psoriasis vulgaris (PV). Materials and methods In this retrospective study, we evaluated the laboratory results of 40 patients who were followed up with a diagnosis of PV and received secukinumab treatment in three different dermatology clinics between July 2018 and September 2019. Results Neutrophil count and leukocyte count were significantly decreased after secukinumab treatment. (P < .001) There was no statistically significant difference between lymphocyte count, platelet count, MPV, NLR and PLR values before treatment and at the 4th month of treatment (P values .230, .065, .110, .915 and .365, respectively). Conclusion In conclusion, it can be concluded that parameters such as NLR, PLR and MPV are not suitable parameters for monitoring the effects of secukinumab treatment on inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study

Aksoy

Ayhan

et al. 2021

Int J Clin Pract

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“…İnflamatuar olaylarda nötrofil sayısının arttığı lenfosit sayısının ise azaldığı bilinmektedir 17 . NLO nötrofil ve lenfosit sayılarını bir arada içeren bir parametre olduğundan inflamasyonu belirlemede daha etkin bir parametre olabileceği düşünülmüş ve son yıllarda yapılan çalışmalarda NLO diğer pek çok inflamatuar hastalıkta 17,18 olduğu gibi yenidoğan sepsisi tanısı için de inflamatuar bir biyobelirteç olarak değerlendirilmiştir 1,11,13,14 .…”

Section: Yöntemlerunclassified

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

Akkeçeci¹,

Seğmen²,

Yurttutan³

et al. 2019

Dicle Tıp Dergisi

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ÖzAmaç: Bu çalışma tam kan sayımı parametrelerinin ve tam kan sayımına dayalı skorların yenidoğan sepsisinde tanısal biyo-belirteç olarak kullanılıp kullanılamayacaklarını belirlemek amacıyla planlanmıştır.Yöntemler: Retrospektif olarak planlanan bu çalışmaya, yenidoğan sepsisi tanısı almış 70 hasta (Grup 1) ve hasta grubuyla benzer yaş, cinsiyet, doğum ağırlığı ve doğum haftasında olan 65 sağlıklı yenidoğan (Grup 2) olarak çalışmaya alındı. Demografik veriler, kan kültürü sonuçları, klinik ve laboratuvar bulguları tıbbi kayıtlardan elde edildi. Nötrofil/lenfosit oranı (NLO), trombosit/lenfosit oranı (TLO), eozinofil/lenfosit oranı (ELO), bazofil/lenfosit oranı (BLO) ve monosit/lenfosit oranı (MLO) gibi tam kan sayımına dayalı skorlar, sırasıyla nötrofil, trombosit, eozinofil, bazofil ve monosit sayısının lenfosit sayısına bölünmesiyle hesaplandı. Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

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Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis

Ayhan

Aksoy

et al. 2020

Dermatologic Therapy

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Cutaneous leishmaniasis (CL) is a vector‐borne parasitic disease characterized by various skin lesions that can cause deformities when healed. Our aim in this study is to show the utility of parameters such as neutrophil/lymphocyte ratio (NLR), thrombocyte/lymphocyte ratio (TLR), and mean thrombocyte volume (MTV) as auxiliary laboratory methods in CL patients. About 107 patients who were admitted to our dermatological and venereal diseases outpatient clinic between January 2018 and January 2019 and were diagnosed with CL by microscopic examination and 74 healthy individuals were included in the study. There were no significant differences between the patient and control group in terms of neutrophil counts, leukocyte counts, platelet counts, and NLR values (P values: .271, .053, .263, and .459, respectively). When the TLR and MTV values of patients with CL and those of the healthy controls were compared, it was found that TLR and MTV values were statistically higher in patients with CL (P values of .010 and .044, respectively). Based on these data, NLR was not considered to be a suitable parameter for demonstrating inflammation in CL patients, but TLR and MTV were held to be an appropriate parameter for demonstrating inflammation in CL patients. In addition, we think that the increase in MTV and TLR, can be used as an auxiliary laboratory test in the diagnosis of CL disease.

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Evaluation of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and mean platelet volume in patients with lichen planus

Cited by 7 publications

References 0 publications

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study

The effect of secukinumab treatment on inflammatory parameters in patients with psoriasis: A multicentre restrospective study

Yenidoğan sepsisinde tam kan sayımı parametrelerinin tanısal değeri

Evaluation of inflammatory parameters in patients with cutaneous leishmaniasis

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