Evaluation of Netrin‐1 Levels and Albuminuria in Patients With Diabetes

Ay, Emre; Marakoğlu, Kamile; Kızmaz, Muhammet; Ünlü, Ali

doi:10.1002/jcla.21965

Cited by 22 publications

(25 citation statements)

References 21 publications

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“…Liu, et al reported that plasma Netrin‐1 levels were lower in newly diagnosed type 2 diabetes mellitus patients than those in healthy controls and also the levels were negatively correlated with blood glucose levels and insulin resistance. Conversely, increased serum Netrin‐1 concentrations in patients with type 2 diabetes have been reported in recent studies . Our results demonstrated decreased serum Netrin‐1 and Unc5b levels in periodontitis patients and also the levels were negatively correlated with the whole mouth inflammatory clinical parameters.…”

Section: Discussionsupporting

confidence: 66%

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Netrin‐1 and its receptor Unc5b as markers of periodontal disease

Günpınar

Meraci

Dündar

2019

J of Periodontal Research

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Objectives The aim of this present study was to evaluate the levels of Netrin‐1 and Unc5b in periodontal health and disease. Background Netrin‐1, acting via its receptor UNC5b, regulates the inflammatory response and takes apart in bone destructive diseases. Methods Samples of gingival crevicular fluid (GCF), whole saliva, and serum were taken from systemically healthy, nonsmoking 20 periodontitis , 20 gingivitis patients, and 20 periodontally healthy subjects at baseline and 4 weeks after nonsurgical periodontal treatment (NSPT). Whole‐mouth and site‐specific clinical periodontal parameters were recorded. Netrin‐1 and Unc5b levels were measured by enzyme‐linked immunosorbent assay. Data were analyzed by nonparametric tests. Results Total amount of Netrin‐1 in GCF was significantly higher in periodontitis than the others, and the levels were significantly reduced after NSPT. Salivary and serum concentrations of Netrin‐1 were significantly different among the study groups (P = .000), and NSPT significantly increased the concentration levels of both salivary and serum Netrin‐1 (P < .05). Healthy subjects had significantly lower GCF (P = .001) and conversely, higher salivary and serum levels of Unc5b than the other groups (P = .002). The GCF levels of Unc5b were significantly reduced (P < .01), and conversely, serum concentrations were significantly increased after NSPT (P < .05). GCF Netrin‐1 and Unc5b total amounts were positively correlated with clinical parameters (P < .01 and P < .05) whereas salivary Netrin‐1 and Unc5b concentrations were negatively correlated with clinical parameters (P < .01 and P < .05). Conclusions The results of this study indicate that Netrin‐1 and its receptor Unc5b may have essential roles in periodontal inflammation and those can be assumed as useful therapeutic agent to control inflammation and periodontal breakdown.

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Section: Discussionsupporting

confidence: 66%

“…Conversely, increased serum Netrin-1 concentrations in patients with type 2 diabetes have been reported in recent studies. 32,33 Our results demonstrated decreased serum Netrin-1…”

Section: Discussionmentioning

confidence: 55%

Netrin‐1 and its receptor Unc5b as markers of periodontal disease

Günpınar

Meraci

Dündar

2019

J of Periodontal Research

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“…Previously, Ay and colleagues reported that serum netrin-1 levels were raised in patients with diabetes whose mean HbA 1c level was 8.1% compared to non-diabetic patients ( 39 ). Also, there was a strong positive correlation between plasma netrin-1 level and HbA 1c , and a significant negative correlation between eGFR, but the study sample was relatively small and a comparative group (such as pre-diabetes) was not included.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes

et al. 2018

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Background: The protein netrin-1 has demonstrated anti-inflammatory, tissue regeneration, and immune modulation properties. Although inflammation is a major contributing factor in the development of insulin resistance and type 2 diabetes, little is known about a possible relationship between serum netrin-1 and type 2 diabetes. Therefore, we investigated the association between circulating levels of netrin-1 and glycometabolic parameters predictive of type 2 diabetes.Methods: Serum samples were collected from 41 normal controls, 85 subjects with impaired fasting glucose (IFG), and 92 subjects with newly diagnosed type 2 diabetes. Clinical and laboratory parameters were assessed and netrin-1 levels were measured by commercial enzyme-linked immunosorbent assay. Spearman correlation analyses and multivariable-adjusted regression analyses were conducted to examine the relationship between serum netrin-1 levels and glycometabolic parameters.Results: Serum netrin-1 levels in subjects with type 2 diabetes or IFG were significantly higher compared to normal controls (441.0, 436.6, and 275.9 pg/mL, respectively; P for trend < 0.001). Serum netrin-1 levels were significantly positively correlated with fasting glucose, HbA1c, and insulin resistance index (all Ps < 0.01). Serum netrin-1 levels were independently associated with IFG or type 2 diabetes (standardized β = 0.405, P < 0.001) after adjusting for covariates and potential confounders. In addition, the receiver operating characteristic (ROC) analysis showed that serum netrin-1 levels could identify the presence of IFG and type 2 diabetes with the area under the ROC curve (AUC) of 0.784 (P < 0.001).Conclusions: Our results suggest that elevated serum netrin-1 levels are significantly associated with the presence of IFG and type 2 diabetes.

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“…Urine netrin-1 concentration has recently received attention as a potential biomarker independently predicting the development of diabetes mellitus and chronic kidney disease. 6,7 In these, a majority of study subjects were those who had already developed chronic renal failure (CRF) with damaged renal function or without diabetes history or just on animal experiments; meanwhile, there were limited data available about the mutual relation between the plasma levels of netrin-1 and inflammation cytokines. The relationship between DN development and plasma netrin-1 levels is unknown.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of netrin-1 in the serum of patients with diabetic nephropathy: Relationship with renal function and inflammation

Liu

Feng

et al. 2018

Eur J Inflamm

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Netrin-1, a survival factor, is highly induced and excreted after renal injury in animal experiments. We aimed to research the relationship between serum netrin-1 and parameters of renal tubule function as well as circulating inflammatory cytokines and to evaluate effect factors for netrin-1 in humans with type 2 diabetes mellitus (T2DM) undergoing different levels of albuminuria. In total, 81 T2DM patients were included and divided into three groups according to their amount of 24-h urine albumin excretion (UAE) after receiving consent. Plasma netrin-1, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were quantified by commercially available enzyme-linked immunosorbent assay kits and the data were analyzed to assess whether serum netrin-1 correlates significantly with disease progression. The results showed that plasma netrin-1 level in patients with macroalbuminuria was significantly higher than that in those with microalbuminuria and normoalbuminuria. Plasma netrin-1 level was significantly associated with UAE, estimated glomerular filtration rate (eGFR), IL-6, and TNF-α independently of age, sex, diabetes duration, and glycosylated hemoglobin (HbA1c). However, no correlation was found between netrin-1 and β2-microglobulin (β2-MG). Our studies may suggest that serum netrin-1 concentrations are increased with diabetic nephropathy progression, particularly in patients with macroalbuminuria, which are associated with renal insufficiency and compensatory responses after inflammation.

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Evaluation of Netrin‐1 Levels and Albuminuria in Patients With Diabetes

Abstract: This study supports that plasma netrin-1 level increases significantly when glomerular damage occurs in diabetic nephropathy.

Cited by 22 publications

References 21 publications

Netrin‐1 and its receptor Unc5b as markers of periodontal disease

Netrin‐1 and its receptor Unc5b as markers of periodontal disease

Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes

Elevated levels of netrin-1 in the serum of patients with diabetic nephropathy: Relationship with renal function and inflammation

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