Evaluation of Natural Change of Skin Function in Split-Thickness Skin Grafts by Noninvasive Bioengineering Methods

Kim, You Jeong; Kim, Mi‐Yeon; Lee, Paik‐Kwon; Kim, Hyung Ok; Park, Young Min

doi:10.1111/j.1524-4725.2006.32306.x

Cited by 18 publications

(16 citation statements)

References 13 publications

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“…Grafts survive initially by the oxygen supply from the wound bed and have to establish their own vascularization. Grafted sites exhibit an impairment in barrier function demonstrated by an increased transepidermal water loss (Gould & Reece, ; Kim, Kim, Lee, Kim, & Park, ).…”

Section: Discussionmentioning

confidence: 99%

Eczema of recipient and donor skin graft sites: Another example of “Ruocco's immunocompromised district”

Verma¹,

Wollina

Ruocco

et al. 2019

Dermatologic Therapy

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A 47‐year‐old male suffered soft tissue injuries 8 years ago that had been covered by meshed split thickness skin graft. During the last 2 years, he developed a chronic eczema (atopic dermatitis) on both recipient and donor sites on the lower extremities. Eczema on skin graft sites has been described rarely. However, this case is unique since both donor and recipient site were involved. We consider our observation as another example of Ruocco's immunocompromised districts of skin.

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Section: Discussionmentioning

confidence: 99%

Eczema of recipient and donor skin graft sites: Another example of “Ruocco's immunocompromised district”

Verma¹,

Wollina

Ruocco

et al. 2019

Dermatologic Therapy

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“…Hyperpigmentation often occurs in human skin autografts after transplantation, sometimes resulting in an unsatisfactory appearance 11 . Little is known about the cytokines or other factors which stimulate pigmentation in skin autografts after transplantation.…”

Section: Discussionmentioning

confidence: 99%

Involvement of melanocortin‐1 receptor in the hyperpigmentation of human skin autografts

Xue

Dai

et al. 2012

The Journal of Dermatology

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Hyperpigmentation frequently occurs in human skin autografts resulting in an unsatisfactory appearance. This study aimed to elucidate the role of melanocortin-1 receptor in the hyperpigmentation process of skin autografts by analyzing the expression of melanocortin-1 receptor. The data were correlated with the amount of melanin in autografted human skin and normal skin determined in a previous study. Immunohistochemistry, western blotting and quantitative real-time polymerase chain reaction were carried out to detect the expression and distribution of melanocortin-1 receptor in skin autografts including full-thickness skin autografts, split-thickness skin autografts and normal full-thickness skin. Fontana-Masson stain was used to detect melanin in all types of skin specimens. The expression level of melanocortin-1 receptor in autografted skin was much higher than that in control normal skin, and thinner split-thickness skin autografts had higher levels of expression of melanocortin-1 receptor than thicker grafts. The amount of melanin in skin autografts was significantly increased compared with normal skin. The expression of melanocortin-1 receptor correlated well with the amount of melanin in the epidermis of skin autografts. These results indicate that melanogenesis is dramatically enhanced in skin autografts by the melanocortin-1 receptor, and suggest that overexpression of melanocortin-1 receptor may play an important role in the hyperpigmented process of skin autografts. This study provides a novel mechanism for hyperpigmentation in skin autografts.

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“…Skin grafting is one of the most useful reconstructive modalities for skin and subcutaneous tissue defects; however, postoperative scars are sometimes a determining factor of patient satisfaction; in particular, the color match between the grafted skin and surrounding recipient skin should be carefully considered and evaluated. Split‐thickness skin grafting is widely used for primary wound coverage after skin cancer resection or relatively extensive skin defect coverage, such as extensive burns, because donor‐site morbidity is lower and wider skin grafts are available 14 . Dark‐skinned patients sometimes show remarkable pigment mismatch because there are profound differences in the degree and extent of melanization between donor and recipient sites, because the disorder of melanization causes either hyperpigmentation or hypopigmentation in the melanocyte–melanosome complex 15 …”

Section: Discussionmentioning

confidence: 99%

Basic fibroblast growth factor is beneficial for postoperative color uniformity in split-thickness skin grafting

Akita

Akino

Yakabe

et al. 2010

Wound Repair and Regeneration

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Color changes of visible and exposed body surfaces, such as the face and extremities, after burn injury or surgery, such as skin grafting, flap, or sclerotherapy for vascular malformations, are sometimes a concern. The consequences reduce the satisfaction of both patients and physicians. An easy and reproducible method has not yet been established for an objective analysis of color changes; therefore, we tested a hand-held color analyzer (NF-333; Nippon Denshoku Co. Ltd) with data transport to a computer database and analysis software for posttreatment skin color change. The parameters included L, a, and b, which measure clarity, red, and yellow, respectively. Two groups were prospectively divided with 20 (11 females and nine males) patients per group. One group received skin grafting plus basic fibroblast growth factor (bFGF) spray daily and the other group received only skin grafting. The patients were randomized by the date of their first visit to our hospital. Patients were treated with bFGF on odd days, while patients who came on even days were included in the non-bFGF-treated group. The donor site for skin grafting was the lateral thighs and the thickness was similar in both groups. The results were compared at 1-year posttreatment follow-up. Clinical and objective assessments of the scars were performed 1 to years after complete healing. Color change differentials in comparison with the surrounding skin were lower with bFGF treatment in all parameters (p<0.01), along with clinical assessment with the Vancouver Scar Scale; therefore, the treatment contribute to a better color match with skin grafting postoperatively.

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Evaluation of Natural Change of Skin Function in Split-Thickness Skin Grafts by Noninvasive Bioengineering Methods

Abstract: Our results showed that the STSGs had changed within the frame of the skin function, including the TEWL, epidermal hydration, color, and pliability, throughout 1 year after surgery. The authors have indicated no significant interest with commercial supporters.

Cited by 18 publications

References 13 publications

Eczema of recipient and donor skin graft sites: Another example of “Ruocco's immunocompromised district”

Eczema of recipient and donor skin graft sites: Another example of “Ruocco's immunocompromised district”

Involvement of melanocortin‐1 receptor in the hyperpigmentation of human skin autografts

Basic fibroblast growth factor is beneficial for postoperative color uniformity in split-thickness skin grafting

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