Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency

Dündar, Yusuf; Akcan, Hümeyra Bayram; Uluat, Ahmet; Cebeci, Derya; Ünlü, İlhan

doi:10.1007/s00405-019-05286-y

Cited by 13 publications

(7 citation statements)

References 30 publications

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“…Nasal mucociliary clearance time was significantly increased in patients with VD deficiency which might be one of the pathophysiologic pathways at increased URTI. 43 Some studies propose that 25(HO) VD may be effective in protecting against respiratory tract infections. 44,45 In spite of the literature, the pathophysiologic pathway of the increased rate of URTI still remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes

Umarov¹,

Kerimov²,

Toychiev³

et al. 2020

J Sports Med Phys Fitness

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BACKGROUND. The aim of this study is to identify seasonal changes in total 25(OH) vitamin D (VD) concentrations and determine its influence on acute upper respiratory tract infection (URTI) morbidity among elite athletes engaged in water sports.METHODS. The study was planned as a prospective, non-interventional, observational study. Study participants included 40 elite athletes and 30 control individuals. Serum levels of 25(OH) VD and TNF-α, IFN-γ, IL-4 and IL-6 were detected by ELISA technique. Morbidity and frequency of acute URTI in participants were determined by self-reported questionnaire during the year. RESULTS. The predominance of VD insufficiency was found in both groups of elite athletes and in the control individuals. Prevalence of VD insufficiency/deficiency depends on the season, but independently on the season the highest values were observed among athletes. VD sufficiency was detected in 30% and 13.3% of the control individuals in August and February and only in 10% of swimmers in August. More than 3 episodes of URTI were detected only in the elite athletes in winter-spring. The elevated level of TNF-α, IL-4, IL-6 was detected in all athletes, but more expressed increase was observed in swimmers. CONCLUSIONS. VD insufficiency is quite pronounced among elite athletes engaged in synchronized swimming and in swimmers. It is accompanied with a decrease of IFN-γ, increase of TNF-α, IL-4 and IL-6 level, and elevation of URTI morbidity. Seasonal monitoring and correction of the VD level for normalization of cytokine profile and decrease of URTI morbidity is definitely advised.

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Section: Discussionmentioning

confidence: 99%

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes

Umarov¹,

Kerimov²,

Toychiev³

et al. 2020

J Sports Med Phys Fitness

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“…The importance of vitamin D is well described; it plays a key role in the activation of the innate immune system [2], particularly during lower respiratory tract infections [3][4][5]. Vitamin D increases mucociliary clearance, regulate epithelial cell production and modulate inflammatory pathways [6].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study

et al. 2021

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Background 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing. Objective To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness. Methods A prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Multivariate logistic regression, adjusted for age, sex, ethnicity and nutrition was performed. Correlation between serum vitamin D levels and bronchiolitis severity was assessed via Modified Tal Score and length of hospital stay (LOS). Results One hundred twenty-seven patients aged < 24 months were recruited; 80 diagnosed with acute bronchiolitis and 47 patients with non- respiratory febrile illnesses. Both groups had similar demographics aside from age (median [IQR] 5 [3–9] vs. 9 [5–16] months in the bronchiolitis group compared to control group (p = 0.002)). Serum 25(OH) vitamin D levels were significantly lower in the bronchiolitis group; median [IQR] 28[18–52] vs. 50[25–79] nmol/L, respectively, (p = 0.005). Deficient vitamin D levels (< 50 nmol/L) was found more frequently in the bronchiolitis group than controls; 73% vs. 51% (p = 0.028). Multivariate logistic regression showed vitamin D deficiency was more probable in bronchiolitis patients; OR [95% CI] 3.139[1.369–7.195]. No correlation was found between serum vitamin D levels and bronchiolitis severity, which was assessed via Modified Tal Score and by length of hospital stay. Conclusion Children with acute bronchiolitis displayed significantly lower vitamin D levels than children with non-respiratory acute febrile illnesses.

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“…2 Mucociliary clearance is a defense mechanism that enables mucosa, which is in the nasal cavity with the particles, to move nasopharynx from the front part of the nose via wave actions of cilias. 3 Disruption of mucociliary clearance causes many pathologies such as rhinitis, sinusitis, otitis media, and odor disorders. 4 The results of the adverse effects of isotretinoin use on the nasal mucosa and mucociliary clearance time (MCT) have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

İşlek¹,

Yıldız²

2020

Ear Nose Throat J

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Objectives: The study aims to investigate the possible side effects of isotretinoin use on the nasal mucosa with objective methods in the treatment of acne vulgaris. Methods: Before the treatment, nasal mucociliary clearance time (MCT) was measured in all patients. Also all patients were asked to complete the questionnaires about the nasal dryness (visual analog scale [VAS]), nasal obstruction (Nasal Obstruction Symptom Evaluation [NOSE]), and presence of epistaxis (Epistaxis Severity Score [ESS]). Both MCT and questionnaires were reevaluated in patients who completed the treatment. Results: The results of 101 patients were evaluated. Before treatment, mean duration of nasal mucociliary clearance (NMC) was 9.55 ± 1.30 minutes, nasal dryness (VAS) value was 2.7 ± 0.7, NOSE score was 2.1 ± 1.1, and ESS score was 1.2 ± 0.7; after treatment, the duration of NMC was 13.80 ± 2.29 minutes, VAS value was 3.3 ± 1.1, NOSE score was 3.2 ± 1.3, and ESS score was 2.1 ± 1.2 ( P = .018, .150, .027, .011, respectively). Conclusion: The nasal mucosa is adversely affected in patients due to regular use of isotretinoin in the acne treatment, anamnesis should be checked in all nasal surgeries, and routine ear nose throat control should be recommended for these patients.

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Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency

Cited by 13 publications

References 30 publications

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes

Association of the 25(OH) vitamin D status with upper respiratory tract infections morbidity in water sports elite athletes

Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study

Evaluation of Nasal Mucociliary Clearance, Nasal Obstruction Symptom Evaluation, and Epistaxis Severity Score in Isotretinoin Treatment

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