Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study

Çanakçıoğlu, Salih; Tahamiler, Rauf; Saritzali, Gkioukxel; Alimoğlu, Yalçın; Işıldak, Hüseyin; Güvenç, M. Güven; Acar, Gül Özbilen; İnci, Ender

doi:10.1016/j.amjoto.2008.06.015

Cited by 39 publications

(25 citation statements)

References 15 publications

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“…Although NAR is a condition most common in both clinical outpatient primary care and in ENT specialist practice, its epidemiology, classifi cation, diagnosis, clinical profi le and treatment are still a matter of discussion (23,24) . The current study defi ned the with comorbidities, and in particular with previously diagnosed asthma and aspirin intolerance with a significant difference in both cases (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Role of inflammation in non-allergic rhinitis

Corso¹,

Battista²,

Pandolfini³

et al. 2014

Rhin

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Objective: To investigate the role of inflammation in non-allergic rhinitis (NAR) patients in a large series to establish the prevalence of different NAR-subtypes, clinical features and the role of nasal cytology in the diagnostic algorithm. Methodology:Patients were selected out of 3650 individuals who spontaneously presented at our institution. We consecutively enrolled 519 NAR-patients in an analytical cross-sectional study between November 2007 and June 2013 (level of evidence: 3b).All patients underwent rhinological evaluation including symptoms questionnaire, endoscopy, CT scan, allergy tests and nasal cytology. Results:The inflammatory cell infiltrate affects the severity of symptoms differently, allowing for identification of different phenotypes of NAR. We distinguished two groups: "NAR without inflammation"(NAR-) and "NAR with inflammation"(NAR+), in addition to different NAR-subtypes with inflammation. A significant difference was observed in terms of clinical symptoms and association with comorbidities (previously diagnosed asthma and aspirin intolerance) between NAR-, NAR+ and between different NAR+ subtypes. Conclusion:Our data suggest that NAR-and NAR with neutrophils behave similarly, showing lower symptom score values and a lower risk of association with comorbidities compared to NAR with eosinophils and mast cells (singularly or mixed). In our belief it is very important to establish the presence and type of inflammation in non-allergic rhinitis patients and nasal cytology is a very useful test in correct differential diagnosis.

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Section: Discussionmentioning

confidence: 99%

Role of inflammation in non-allergic rhinitis

Corso¹,

Battista²,

Pandolfini³

et al. 2014

Rhin

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“…The cells were smeared on glass slides, fixed with alcohol, stained with hematoxylin and eosin (H & E) and evaluated under the light microscope. In the evaluation of the cytograms of each patient it was found that they could be classified to one of the six types of cytograms, previously described by Canakcioglu et al [26].…”

Section: Cytologymentioning

confidence: 96%

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Dżaman

Zagor

Molińska-Glura

et al. 2015

Folia Histochem Cytobiol.

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Introduction. Chronic rhinosinusitis (CRS) affects 14% of the world population. The high motility group box 1 (HMGB1) protein triggers inflammation, cell proliferation and cell survival through its receptor for advanced glycation end products (RAGE) upon release from stressed or necrotic cells. The aim of the study was to analyze the expression and function of HMGB1 and RAGE in CRS, providing more information about HMGB1 signaling pathway in CRS, to determine its potential clinical significance. Material and methods. Thirty-seven patients with CRS and 26 normal controls (NC) were enrolled in this study. Classification of disease severity using the SNOT-20 questionnaire, nasal endoscopy, CT scan, assessment of allergy status, microbiological and cytological analysis was performed in patients. Fresh sinus mucosa samples were obtained and analyzed by immunohistochemistry for HMGB1 and RAGE expression in epithelial cells. ELISA assay was performed to evaluate the concentration of HMGB1 in the patients' sera. Results. No differences were found in HMGB1 immunoexpression between CRS patients and NC, however there was a highly significant difference in RAGE immunoexpression between both groups. There was a correlation between RAGE expression and number of tissue-infiltrating lymphocytes. Further, RAGE expression positively correlated with disease severity and a positive history for allergies. Conclusions. Interaction of HMGB1 and RAGE might be relevant to CRS pathomechanisms leading to sinus mucosa hyperproliferation. CRS pathogenesis might be especially related to the RAGE overexpression correlated with disease severity and allergy.

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“…However, recent literature has provided evidence that some patients with rhinitis show nasal allergy with no systemic markers of atopy, either by local IgE production or even through an IgE-independent antigen-specific pathway [8,9]. In addition, it has been suggested that this condition may be prevalent in up to one third of adults with nonallergic rhinitis, and although it usually occurs as an isolated disorder, there is evidence of association with asthma, aspirin sensitivity and nasal polyps [10,11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome

Gröger

Klemens

Wendt

et al. 2012

Int Arch Allergy Immunol

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Background: Patients with nonallergic rhinitis with eosinophilia syndrome (NARES) show typical symptoms of persistent allergic rhinitis (PAR). The aim of the present study was to compare nasal cytokine patterns between NARES and PAR. Methods: Nasal secretions of 31 patients suffering from NARES, 20 patients with PAR to house dust mite and 21 healthy controls were collected using the cotton wool method and analyzed for interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1β (MIP-1β) by Bio-Plex Cytokine Assay as well as eosinophil cationic protein (ECP) and tryptase by UniCAP-FEIA. Results: NARES and PAR presented elevated levels of tryptase, while ECP was markedly increased solely in NARES compared to both the controls and PAR. Elevated levels of IL-1β, IL-17, IFN-γ, TNF-α and MCP-1 were found in NARES compared to the controls as well as PAR. MIP-1β was elevated in NARES and PAR, while IL-4, IL-6 and G-CSF showed increased levels in NARES, and IL- 5 was elevated in PAR only. Conclusions: In patients with NARES and PAR, eosinophils and mast cells appear to be the pivotal cells of inflammation, reflected by high levels of tryptase and ECP as well as IL-5 and GM-CSF as factors for eosinophil migration and survival. The elevated levels of proinflammatory cytokines in NARES may indicate the chronic, self-perpetuating process of inflammation in NARES which seems to be more pronounced than in PAR. IL-17 might be a factor for neutrophilic infiltration or be responsible for remodeling processes in NARES.

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Evaluation of nasal cytology in subjects with chronic rhinitis: a 7-year study

Cited by 39 publications

References 15 publications

Role of inflammation in non-allergic rhinitis

Role of inflammation in non-allergic rhinitis

High motility group box 1 (HMGB1) protein and its receptor for advanced glycation end products (RAGE) expression in chronic rhinosinusitis without nasal polyps

Mediators and Cytokines in Persistent Allergic Rhinitis and Nonallergic Rhinitis with Eosinophilia Syndrome

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