Evaluation of Naringenin as a Promising Treatment Option for COPD Based on Literature Review and Network Pharmacology

Abstract

Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by incompletely reversible airflow limitation and seriously threatens the health of humans due to its high morbidity and mortality. Naringenin, as a natural flavanone, has shown various potential pharmacological activities against multiple pathological stages of COPD, but available studies are scattered and unsystematic. Thus, we combined literature review with network pharmacology analysis to evaluate the potential therapeutic effects of naringenin on COPD and predict its underlying mechanisms, expecting to provide a promising tactic for clinical treatment of COPD.

The Effects of Naringenin on miRNA-mRNA Profiles in HepaRG Cells

“…NFκB is a key regulator of immune development, immune responses, inflammation, and cancer [ 47 ]. It has been well-established that suppressing NFκB transduces anti-inflammatory signals and reduces inflammation [ 48 ]. In the PI3K–Akt signaling pathway, our results showed that naringenin significantly down-regulated the mRNA expressions of PDGFRB, PCK1, CREB3L1, and NFκB1 with related miRNAs (has-miR-1306-5p and hsa-miR-627-3p) being significantly down-regulated.…”

Experimental elucidation of an antimycobacterial bacteriocin produced by ethnomedicinal plant-derived Bacillus subtilis (MK733983)

“…Hemolytic activity on the bacteriocin was investigated according to the methods described by Wu et al ( 2020 ), Afsar et al ( 2016 ) and Soto ( 2014 ) with minimal variations. Fresh pellet of erythrocytes from Goat blood was adjusted to a concentration of 5% in saline solution.…”

“…Morphological Changes on treatment with bacteriocin were evaluated according to the methods described by Wu et al ( 2020 ) and Park et al ( 2002 ) with slight variations. S. aureus , a gram-positive and P. aeruginosa, gram-negative IMO were grown in standard LB broth, incubated at 37 °C for 24 h. The indicator cells (probably in stationary phase) were suspended in saline and treated with the same volume of the bacteriocin (1 mg/mL), the untreated cells were taken as control.…”

Image1.TIF

“…Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease, characterized by airflow limitation that is not completely reversible. COPD patients experience declines in lung function resulting in great economic and social burdens worldwide (Vestbo et al, 2013;Ma et al, 2019;Mao et al, 2019;Sun et al, 2019;Chen et al, 2020). Studies reveal that COPD will become the third leading cause of death worldwide by 2030, and it is estimated that over 5.4 million people will die from COPD annually from 2060 (Singh et al, 2019;Belchamber and Donnelly, 2020;Chen et al, 2020).…”

“…The 15q24/25 locus in nAChR is correlated with the occurrence and progression of emphysema, suggesting that it is causally involved in alveolar destruction, a pathogenic mechanism potentially shared with COPD (Lambrechts et al, 2010). In addition, the precise pathogenesis mechanisms of COPD remain unclear (Chen et al, 2020;Wang et al, 2020). Thus, it is critical to elucidate the molecular mechanisms underlying COPD for its treatment.…”