Evaluation of Myrmecodia pendans Water Extracts on Hematology Profiles, Liver, Kidney Function and Malondialdehyde Level in Healthy Volunteer

Abstract

Background: Ant Nest (Myrmecodia pendans) is one of plants that have been used by locals in Indonesia to empirically treat various diseases. Ant Nest in vitro and in vivo studies on animals have been widely reported its pharmacological activities as an antioxidant. Unfortunately, scientific proofs reported on this plant as human medicine are still lacking. Aim: This study aimed to ensure effectiveness, and safety due to administration of Ant Nest Water Extract (ANWE) formulated in capsule. Materials and Methods: Twelve volunteers were divided into 2 groups, 6 volunteers in each group. Group I: Ant Nest Water Extract Capsule (ANWEC) in dose of 350 mg ANWE, and group II: Placebo Capsule (PC) which contained 350 mg amylum. Each groups given the capsule once daily for 28 days. The comparison was made between group I and group II. Hematology tests include hemoglobin, leucocyte and thrombocyte. Blood chemistry tests include SGOT, SGPT, total cholesterol, triglycerides, HDL, LDL, glucose, ureum (Ur) and creatinine (Cr). Malondialdehyde (MDA) level was measured at day-28 which was the last day of the intervention. Results: After 28 days administration of ANWE, the SGOT, SGPT, Ur, and Cr showed in normal level as follows SGOT (U/L): 19.2 ± 3.99; SGPT (U/L): 17.2 ± 6.80; Ur (mg/dL): 19.75 ± 3.66; Cr (mg/dL): 1.06 ± 0.13. MDA (ng/mL) level in ANWEC-treated group was significantly lower (117.2±23.8) than PC (147.25±18.7). There was no intolerable complaints during the observation. Conclusion: The study concluded that Water Extract of Ant Nest 350 mg has no damage to liver, kidney and hematology, so it was proven that this plant is safed to be consumed by human for its potency as antioxidant.

The Effect of Myrmecodia pendans Ethanol Extract on Myeloperoxidase Level and Histopathological appearance in Dextran Sodium Sulfate-Induced Colitis Rat

“…M.pendans extract decreased TNF-α in pulpitis rats on day 4. 7 Thus, Nucky et al, showed that the ethanol extract of M. pendans had an anti-inflammatory effect by decreasing levels of the inflammatory mediator TNF-α in the blood in which phytochemical compounds from the fractioned extract were flavonoids. 22 As shown in Figure 1A, the black arrow indicates that part of the colon that has epithelial erosions that is seen at 40x magnification.…”

“…E mail: tw_rozan@yahoo.com; tri.widyawati@usu.ac.id Tel: +628126582932 One of the plants that has the potential and interest of the public as traditional medicine is Myrmecodia pendans. 7 This plant has the potential to treat various cancers, tumours, gout, coronary heart disease, haemorrhoids, tuberculosis, migraines, rheumatism, and leukemia. 8 Previous studies have revealed that flavonoids are the main active substances found in M. pendans.…”

Slow-type Interval Training and Ethanol Extract of Sarang Semut (Myrmecodia pendans) can Improve the Early Lesions of Atherosclerosis in Type-2 Diabetes Mellitus Rats

“…Sarang Semut is widely used in West Papua as herbal medicine [6], [7], [8]. Ethanol extract of Sarang Semut contains flavonoids that function as antioxidants that can reduce free radical damage [9], [10]. This study aims to analyze the effect of the combination…”